| Seroliv Ltd | Real estate | 2026 |
| Serve & Share Ltd | Manufacturing | 2023 |
| Servocare Lifesciences Private Limited | Wholesale & retail | 2024 |
| Seven Holdings (UK) Limited | Real estate | 2011 |
| Sevlow MRO Limited | Wholesale & retail | 2019 |
| SG Driver Ltd | Transport & logistics | 2023 |
| SG Homes U.K. Ltd | Real estate | 2026 |
| SG Legacy Holdings Group Limited | Financial services | 2026 |
| SG Thind Limited | Transport & logistics | 2022 |
| SGA Transport Ltd | Transport & logistics | 2021 |
| Sgrn Estates Limited | Real estate | 2026 |
| Shaan Transport Limited | Transport & logistics | 2021 |
| Shahdin & Sons Limited | Hospitality | 2025 |
| Shaka Landscape Ltd | Administrative & support | 2025 |
| Shalarevents Ltd | Hospitality | 2025 |
| Sham Beauty Collective Ltd | Other services | 2026 |
| Shane Nickle Rail Ltd | Construction | 2019 |
| Shaw International Ltd | Transport & logistics | 2023 |
| Shayne Smith Couriers Limited | Transport & logistics | 2013 |
| Shergill Transport Services Ltd | Transport & logistics | 2026 |
| Shergill UK Properties Ltd | Real estate | 2024 |
| Sheva Consultancy Limited | Wholesale & retail | 2023 |
| Shield Automotive Ltd | Wholesale & retail | 2024 |
| Shiloh Homes Ltd | Real estate | 2025 |
| Shine Builder and Contractors Ltd | Construction | 2024 |
| Shine Star Limited | Other services | 2011 |
| Shinestrike Limited | Real estate | 2003 |
| Shingers Limited | Wholesale & retail | 2016 |
| Shiny Hand Car Wash Willenhall Ltd | Administrative & support | 2024 |
| Shoolin Enterprises Limited | Financial services | 2020 |
| Shop-Ads Ltd | Professional & scientific | 2016 |
| Shopoholics Ltd | Wholesale & retail | 2025 |
| Short Heath Iron and Steel Limited | Wholesale & retail | 2017 |
| Short Heath Lest WE Forget Community Interest Company | Other services | 2020 |
| Shri Mani Ltd | Wholesale & retail | 2026 |
| Shunli (JG) Ltd | Hospitality | 2022 |
| Sidhu Construction & Services Ltd | Construction | 2025 |
| Sildun Holdings Limited | Professional & scientific | 2011 |
| Sildun Manufacturing (2001) Limited | Manufacturing | 2009 |
| Silvaque Limited | Professional & scientific | 2023 |
| Silverford Enterprises Limited | Wholesale & retail | 2025 |
| Silverline SFS Ltd | Manufacturing | 2026 |
| Silvermoon International Limited | Other services | 2021 |
| Silverstone Willenhall Limited | Hospitality | 2025 |
| Simon Rollason Ltd | Professional & scientific | 2018 |
| Simply Design & Build Limited | Other services | 2022 |
| Simply Medicals - PCV, Taxi & HGV Medicals Ltd | Health & social care | 2018 |
| Simply the Best Care Solutions Limited | Hospitality | 2023 |
| Singh Capital Ltd | Financial services | 2021 |
| Singh Logix Limited | Transport & logistics | 2025 |
| Singh Saab Films Ltd | Information & communication | 2023 |
| Sinjari Limited | Construction | 2022 |
| Sisiba Media Limited | Wholesale & retail | 2025 |
| SJ Footcare Ltd | Real estate | 2024 |
| SJ Tyres (Willenhall) Limited | Manufacturing | 2025 |
| SJA Estates Ltd | Real estate | 2026 |
| SJJ Packaging Ltd | Administrative & support | 2015 |
| SK Device Hub Limited | Wholesale & retail | 2026 |
| SK Sandhu Construction Ltd | Construction | 2024 |
| SKF Wholesale Limited | Wholesale & retail | 2018 |
| Skillspring Ltd | Water & waste | 2024 |
| SKJ Properties (Midlands) Limited | Real estate | 2016 |
| SKT Contracting Limited | Professional & scientific | 2018 |
| Sky View Contractors Ltd | Construction | 2026 |
| Sky View Juice Ltd | Wholesale & retail | 2020 |
| Skyrocket and Grow Limited | Professional & scientific | 2021 |
| Skyview Property Ltd | Real estate | 2021 |
| Skyview Windows Ltd | Construction | 2020 |
| Slaav Limited | Transport & logistics | 2026 |
| Smallman Holdings Limited | Professional & scientific | 2024 |
| Smart Build Work Ltd | Construction | 2025 |
| Smart Cremation Ltd | Other services | 2024 |
| Smart Tech Logistics Ltd | Wholesale & retail | 2024 |
| Smart Tiger Transport Solution (Stts) Ltd | Transport & logistics | 2024 |
| Smart Wire Installations Limited | Construction | 2017 |
| Smartcuts Limited | Other services | 2007 |
| Smarthouse Limited | Construction | 2024 |
| Smartkuts Limited | Other services | 2023 |
| Smartstrong Ltd | Administrative & support | 2025 |
| SMC Evolution Limited | Hospitality | 2020 |
| SMD Couriers Ltd | Transport & logistics | 2023 |
| SME Autocentre Limited | Manufacturing | 2013 |
| Smith Site Engineering Limited | Construction | 2023 |
| Smith Ventilation Limited | Construction | 2019 |
| SMK Pro Limited | Administrative & support | 2009 |
| SNA Productions Limited | Arts & recreation | 2016 |
| Snow Goose Drones Limited | Construction | 2016 |
| Snowdon Coding Solutions Ltd | Information & communication | 2024 |
| Snowdrop Support Ltd | Health & social care | 2024 |
| Snuggle Bugs Nursery Ltd | Health & social care | 2025 |
| SNW Products Ltd | Wholesale & retail | 2025 |
| Socianet Limited | Professional & scientific | 2025 |
| Sockarooeu Ltd | Wholesale & retail | 2025 |
| SOE Enterprises Ltd | Professional & scientific | 2025 |
| Sohi Transport Limited | Transport & logistics | 2022 |
| Solar Screens (Midlands) Limited | Wholesale & retail | 2005 |
| Solartan Limited | Other services | 2021 |
| Solidskills Limited | Education | 2024 |
| Solinth Ltd | Information & communication | 2025 |
| Somal Legal Limited | Professional & scientific | 2022 |