| Erin Olivia Properties Ltd | Real estate | 2022 |
| ESE Group Holdings Limited | Manufacturing | 2017 |
| ESO Education and Training (NW) Ltd | Education | 2019 |
| Esposito Caffes Limited | Hospitality | 2015 |
| Esposito's Community Cafe Limited | Hospitality | 2022 |
| Esposito's in the Park Limited | Hospitality | 2017 |
| Esposito's Wholesale Limited | Wholesale & retail | 2018 |
| Espositos Deli Limited | Hospitality | 2015 |
| Essentials Hair & Beauty Supplies Limited | Wholesale & retail | 2009 |
| Eternal Brilliance Ltd | Hospitality | 2022 |
| Ethercom Limited | Information & communication | 2022 |
| Eton Events Ltd | Other services | 2005 |
| Euclid Vision Group Limited | Manufacturing | 1998 |
| Euro Stars Widnes Ltd | Wholesale & retail | 2022 |
| Eurotrucklink Ltd. | Wholesale & retail | 2023 |
| EV RAY Ltd | Construction | 2024 |
| Evdermia UK Limited | Wholesale & retail | 2017 |
| Everwarme Heating Limited | Wholesale & retail | 2019 |
| EVI Logistics Ltd | Transport & logistics | 2016 |
| Evolve HR & Consulting Ltd | Professional & scientific | 2025 |
| Evove Ltd | Water & waste | 2015 |
| Ewmar Ltd | Professional & scientific | 2024 |
| Excel NW Ltd | Other services | 2020 |
| Excidium Limited | Construction | 2017 |
| Exclusive Trading Group Ltd | Wholesale & retail | 2024 |
| Executive Consulting Ltd | Professional & scientific | 2018 |
| Executive Travel N/W Ltd | Administrative & support | 2012 |
| EXP (North West) Ltd | Manufacturing | 2018 |
| Express Trade Supplies Ltd | Wholesale & retail | 2022 |
| Expressway Industrial Estates Limited | Real estate | 2021 |
| F. J. Aldridge & Sons Limited | Construction | 2015 |
| F2 Watches Limited | Wholesale & retail | 2026 |
| FAB Formwork and Reinforcement Limited | Manufacturing | 2016 |
| Fabformwork Limited | Construction | 2019 |
| Faboss Logistics Limited | Wholesale & retail | 2022 |
| Facile Software Limited | Information & communication | 2022 |
| Fairfield Flooring Limited | Construction | 2013 |
| Fairfield RMG Limited | Professional & scientific | 2025 |
| Fairtech Contracting Limited | Administrative & support | 2012 |
| Family Bakery (Widnes) Ltd | Hospitality | 2023 |
| Fantasy Furlong Ltd | Information & communication | 2018 |
| Farasha Estates Limited | Real estate | 2026 |
| Farndale Developments Limited | Construction | 2017 |
| Farnworth Cleaners Ltd | Other services | 2019 |
| Farnworth Flats Management Company Limited | Real estate | 2024 |
| Farnworth Wraparound Care CIC | Health & social care | 2023 |
| Fast Transporter Ltd | Transport & logistics | 2021 |
| Fasttrack Car Transport Ltd | Transport & logistics | 2024 |
| Fayes Fancies Ltd | Manufacturing | 2023 |
| FD Accountants and Tax Advisers Limited | Professional & scientific | 2017 |
| FD Plastix, Toolz & Sparez Ltd | Wholesale & retail | 2026 |
| FD Waste Solutions Ltd | Water & waste | 2023 |
| Feggio Ltd | Manufacturing | 2024 |
| Femme Hair Limited | Other services | 2015 |
| Femo ZEE Limited | Health & social care | 2025 |
| Fence IT (Cheshire) Limited | Manufacturing | 2017 |
| Fencewright Limited | Construction | 2012 |
| Fenwell Tech Ltd | Information & communication | 2026 |
| Fiddlers Ferry Driving Range Limited | Other services | 2017 |
| Field Brown Motors Ltd | Wholesale & retail | 2020 |
| Fienix Systems Limited | Information & communication | 2024 |
| Figtree Healthcare Ltd | Wholesale & retail | 2009 |
| Figtree Pharmaceutical Ltd | Wholesale & retail | 2025 |
| Fillmore Investments Ltd | Real estate | 2025 |
| FIN Footwear Ltd | Wholesale & retail | 2022 |
| Finance Professional Recruitment Limited | Administrative & support | 2024 |
| Findlay Marine Limited | Administrative & support | 2006 |
| Finley James Developments Ltd | Real estate | 2022 |
| Fire Insulation Solutions Ltd | Manufacturing | 2023 |
| Firebird Transport Ltd | Transport & logistics | 2015 |
| Fireshield Construction Ltd | Construction | 2025 |
| First Class Learning Widnes Ltd | Education | 2022 |
| First FIX Facades Ltd | Construction | 2025 |
| FIVE80 Management and Consultancy Limited | Real estate | 2013 |
| Fiviane Fashion Design and Alterations Ltd | Manufacturing | 2020 |
| FJC Consulting Ltd | Professional & scientific | 2022 |
| FKR Haulage Ltd | Transport & logistics | 2025 |
| Flair Signs (NW) Limited | Other services | 2015 |
| Flex Fleet Logistics Limited | Transport & logistics | 2025 |
| Flex Project Management Ltd | Professional & scientific | 2012 |
| Flightcomments.Com Limited | Information & communication | 2023 |
| Flooring (Cheshire) Limited | Construction | 2012 |
| Florence and the Bear Limited | Hospitality | 2013 |
| Floss World Ltd | Manufacturing | 2025 |
| Flyinggood Ltd | Hospitality | 2024 |
| Flytta Limited | Administrative & support | 2024 |
| Fone Store Ltd | Other services | 2020 |
| Football FUN Factory (Community 097) Limited | Arts & recreation | 2023 |
| Forbeats Limited | Administrative & support | 2009 |
| Force Offshore Services Ltd | Construction | 2025 |
| Forexclash Ltd | Information & communication | 2025 |
| Forktruck Warehouse Europe Limited | Manufacturing | 1971 |
| Fortified Safety Solutions Ltd | Professional & scientific | 2024 |
| Fortis Aluminium Ltd | Manufacturing | 2014 |
| Fortis Engineering Services Ltd | Construction | 2015 |
| Fortis Site Services Limited | Manufacturing | 2016 |
| Fortress Lifting Solutions Ltd | Construction | 2017 |
| Foundry Community Church Ltd. | Other services | 2017 |
| Foundry Lane Service Station Ltd | Manufacturing | 2025 |
| Fourfortytwo Studio Ltd | Manufacturing | 2025 |