| Spectrum GEO Limited | Mining & quarrying | 1986 |
| Speedbird Media Ltd | Professional & scientific | 2017 |
| Spekki Creative Industries Limited | Administrative & support | 2012 |
| Spencer Houzzz Limited | Real estate | 2024 |
| Spencer SPV Limited | Real estate | 2025 |
| Spencer's Accountancy and Business Services Limited | Professional & scientific | 2002 |
| SPI Law Ltd | Professional & scientific | 2018 |
| Spice Dine Ltd | Hospitality | 2025 |
| Spin Energy Limited | Energy | 2023 |
| Spirit & Co Design Limited | Information & communication | 2019 |
| Sportscompany Limited | Information & communication | 2025 |
| Spot on Decoraters Limited | Other services | 2014 |
| Spotlight Sports Group Limited | Manufacturing | 1997 |
| SPR OIL & GAS Innovation Services Ltd | Professional & scientific | 2014 |
| Spray and Forget Limited | Extraterritorial | 2012 |
| Spray Away Limited | Extraterritorial | 2011 |
| Spray Foam Tech Ltd | Construction | 2020 |
| Spring Impact | Other services | 2012 |
| Spring Impact (Trading) Limited | Other services | 2012 |
| Springboard Ventures Ltd | Professional & scientific | 2015 |
| Springfield Residents Association Limited | Households | 1996 |
| Sprinkleink Ltd | Wholesale & retail | 2019 |
| SQM Tiling Contractors Ltd | Construction | 2016 |
| Sr&F Limited | Professional & scientific | 2023 |
| Srjk Limited | Real estate | 2023 |
| SRK Furnished Homes Limited | Real estate | 2020 |
| SSD Enterprises Ltd | Wholesale & retail | 2019 |
| SSI Strategy UK Holdings Limited | Financial services | 2023 |
| ST George's Close Residents Association Limited | Households | 1963 |
| ST George's Lodge Owners Association Limited | Real estate | 2014 |
| ST Georges Veterinary Centre Limited | Professional & scientific | 2012 |
| ST James Court Investment LLP | | 2013 |
| ST John's Close Developments Limited | Real estate | 2017 |
| ST Martins Court LLP | | 2011 |
| ST Mary's House (Southampton) Limited | Real estate | 2016 |
| ST Patrick's Missionary Society Trustee Limited | Other services | 2014 |
| ST Paul's Solicitors Limited | Professional & scientific | 2014 |
| ST Vincent Ferrer Homes Limited | Professional & scientific | 2004 |
| ST Vincent Ferrer Limited | Professional & scientific | 2003 |
| ST Vincent Homes Limited | Construction | 2003 |
| ST. George's Gate Residents Company Limited | Households | 1995 |
| ST. George's Hill Lawn Tennis Club Limited | Arts & recreation | 1971 |
| St.Albans Jvco Ltd | Financial services | 2025 |
| St.Albans Propco Limited | Real estate | 2025 |
| St.George's Hill Residents Association Limited | Households | 1932 |
| St.Georges Hill Golf Club Limited | Arts & recreation | 1912 |
| Stable Minds EFP Limited | Education | 2024 |
| Stafford LEA Limited | Administrative & support | 2004 |
| Stakehill BID Ltd | Professional & scientific | 2021 |
| Stammers Services Ltd | Information & communication | 2019 |
| Stantons (Weybridge) Limited | Wholesale & retail | 1958 |
| Staplands Manor (Weybridge) Management Company Limited | Households | 2017 |
| Star UK Limited | Professional & scientific | 1997 |
| Starspay Limited | Information & communication | 2019 |
| Statham Scry Ltd | Professional & scientific | 2022 |
| Station Road Addlestone Limited | Real estate | 2012 |
| Steltix UK Limited | Administrative & support | 2011 |
| Stepchange Global Consultancy Limited | Professional & scientific | 2012 |
| Stephen Dunne Post Ltd | Arts & recreation | 2018 |
| Stephen Tonkin Chef Consultancy Ltd | Hospitality | 2014 |
| Stephenson Design Studio Ltd | Professional & scientific | 2025 |
| Steps - Drama, Learning, Development Ltd. | Professional & scientific | 1995 |
| Steps Insight Ltd | Professional & scientific | 2018 |
| Sterling & Law Limited | Financial services | 1997 |
| Sterling & Law Wealth Management Limited | Administrative & support | 2002 |
| Sterling Ellis Limited | Professional & scientific | 2012 |
| Steve Willox Limited | Wholesale & retail | 2012 |
| Stevenson Consulting Associates Ltd | Professional & scientific | 2003 |
| STF Media Ltd | Information & communication | 2020 |
| Stir Limited | Wholesale & retail | 2017 |
| Stirlin Financial Limited | Professional & scientific | 2020 |
| Stirling Atlantic Associates Ltd | Administrative & support | 2009 |
| Stoked Eats Ltd | Hospitality | 2017 |
| Stone Automation Limited | Wholesale & retail | 2022 |
| Stone Italiana UK Limited | Extraterritorial | 2012 |
| Stone Traders UK Ltd | Administrative & support | 2007 |
| Stone's of London Limited | Professional & scientific | 1916 |
| Stony Street Wine House Limited | Hospitality | 2018 |
| Storm Property Developments Limited | Real estate | 1999 |
| Stormont Ventures Limited | Financial services | 2024 |
| Story 9 Ltd | Professional & scientific | 2023 |
| Story and Strategy Ltd | Professional & scientific | 2018 |
| Story Mode Media Limited | Information & communication | 2019 |
| Story of Aurum Ltd | Extraterritorial | 2025 |
| Story Staging Limited | Professional & scientific | 2025 |
| Storytime Media Ltd | Professional & scientific | 2025 |
| Stowells of Chelsea Limited | Professional & scientific | 1992 |
| Stradbrook Acquisitions (Holdings) Limited | Professional & scientific | 2014 |
| Stradbrook Acquisitions Limited | Professional & scientific | 2007 |
| Stradbrook Holdings Limited | Professional & scientific | 1920 |
| Strategy to Action Consulting Limited | Professional & scientific | 2020 |
| Stratheden Court Limited | Households | 2021 |
| Streamcore Media Ltd | Information & communication | 2025 |
| Street Dog Productions Limited | Information & communication | 2023 |
| Strong Curves Ltd | Information & communication | 2016 |
| Structure Diagnostics Limited | Professional & scientific | 2020 |
| Strumberg Ltd | Mining & quarrying | 2018 |
| Studio MC Ltd | Arts & recreation | 2019 |
| Studio Shan Ltd | Professional & scientific | 2021 |
| STUDIO17 Barbers Ltd | Other services | 2024 |