| Shot Taker Limited | Wholesale & retail | 2015 |
| Shotgungroup Ltd | Professional & scientific | 2015 |
| Showhome Sales Limited | Real estate | 2013 |
| Shulton (Great Britain) Limited | Professional & scientific | 1956 |
| Shurgard Services UK Limited | Extraterritorial | 2002 |
| Shurgard Storage Centres UK Limited | Extraterritorial | 1997 |
| Shurgard UK Limited | Transport & logistics | 2003 |
| Shurgard UK LNS Holdings Limited | Other services | 2000 |
| Shurgard UK LNS Semco E Limited | Extraterritorial | 1974 |
| Shurgard UK LNS Semco Limited | Real estate | 1943 |
| Shurgard UK LNS Semco M Limited | Extraterritorial | 1971 |
| Shurgard UK LNS Trading Limited | Other services | 1994 |
| Shurgard UK TBR Limited | Other services | 2009 |
| Shurgard UK West London Limited | Transport & logistics | 2004 |
| Shurland Development Ltd | Real estate | 2016 |
| Sible Ltd | Wholesale & retail | 2019 |
| Silent CUT Media Limited | Information & communication | 2012 |
| Silk Skin Studio Ltd | Other services | 2025 |
| Silkwood Export Consultants Limited | Administrative & support | 2009 |
| Silver Birches Learning Ltd | Professional & scientific | 2026 |
| Silver Screen Cameras Limited | Information & communication | 2026 |
| Silverdale Weybridge Limited | Construction | 2016 |
| Silvergate Property Management Ltd | Real estate | 2025 |
| Silversea Cruises (Europe) Limited | Administrative & support | 1996 |
| Silversea Cruises (UK) Limited | Administrative & support | 1996 |
| Silversea Holding (UK) Ltd | Financial services | 2023 |
| Simon Leeks Ltd | Construction | 2005 |
| Simplex Software Solutions Limited | Information & communication | 1997 |
| Simply Digital Group Ltd | Professional & scientific | 2024 |
| Simply Support Services Ltd | Administrative & support | 2020 |
| Sinclair Recruitment Solutions Ltd | Administrative & support | 2017 |
| Sinnamon Projects Ltd | Professional & scientific | 2019 |
| Sinoasia Belt and Road UK Limited | Wholesale & retail | 2020 |
| Siriki Jewellers Limited | Manufacturing | 2012 |
| Sisikon Limited | Extraterritorial | 2011 |
| SIX Sense Strategy Ltd | Wholesale & retail | 2019 |
| SJ Bealing Limited | Financial services | 2010 |
| Sjod Project Management Limited | Construction | 2023 |
| SK Hynix UK Limited | Wholesale & retail | 1995 |
| Skarbek Associates Limited | Professional & scientific | 2012 |
| Skarbek Holdings Limited | Financial services | 2012 |
| Skeeno Productions Limited | Arts & recreation | 2023 |
| Skin Kontrol Ltd | Wholesale & retail | 2025 |
| Skinhairbeauty Ltd | Other services | 2025 |
| Skinners Reproduction Furniture Limited | Wholesale & retail | 1994 |
| SKK Media Ltd | Other services | 2019 |
| Sky-Iron Solutions Limited | Information & communication | 2023 |
| Skylark Flower Company Limited | Agriculture & fishing | 2018 |
| Skylark Ventures Limited | Construction | 2016 |
| Skyline Interior Design Limited | Professional & scientific | 1999 |
| Slade & Co Mortgage Solutions Limited | Financial services | 2021 |
| Slipstream Direct LLP | | 2020 |
| Slipstream Enterprise Limited | Real estate | 2020 |
| Smart Accounting Surrey Limited | Professional & scientific | 2022 |
| Smart Wealth Limited | Real estate | 2022 |
| Smartpath Digital Limited | Professional & scientific | 2011 |
| Smartwash (Weybridge) Ltd | Other services | 2022 |
| Smashed COW Ltd | Hospitality | 2023 |
| Smith GW Ltd | Construction | 2022 |
| Smithard & Co Limited | Financial services | 2001 |
| SML Property Limited | Extraterritorial | 2018 |
| Smooth Sales Leadership Limited | Professional & scientific | 2017 |
| Smrtspace Consulting Ltd | Professional & scientific | 2023 |
| SMS Productions Ltd | Information & communication | 2018 |
| Smtb Services Limited | Information & communication | 2001 |
| SMV UK Limited | Administrative & support | 2010 |
| Snapmail Ltd | Other services | 2016 |
| SND Automotive Limited | Wholesale & retail | 2015 |
| Snitcher Legal Services Limited | Professional & scientific | 2021 |
| Snowdrop Properties Limited | Professional & scientific | 2002 |
| Sochitel UK Ltd | Information & communication | 2006 |
| Social Amour Ltd | Professional & scientific | 2020 |
| Soda Plan Ltd | Professional & scientific | 2022 |
| Soe(Uk) Ltd | Wholesale & retail | 2020 |
| SOL Enterprises PVT. Ltd. | Wholesale & retail | 2012 |
| Solar Group Limited | Professional & scientific | 2018 |
| Solo Consulting Ltd | Administrative & support | 2024 |
| Solo Sports Co. Ltd | Professional & scientific | 2023 |
| Solowei Group Ltd | Information & communication | 2023 |
| Solus Post Production Ltd | Information & communication | 2013 |
| Solutions Electrical Ltd | Construction | 2017 |
| Solutions Training & Advisory Limited | Education | 1994 |
| Solutions TS Ltd | Construction | 2016 |
| Sonic Harmonic Limited | Information & communication | 2017 |
| Sony Global Treasury Services PLC | Administrative & support | 2000 |
| Soranzo Ltd | Information & communication | 2020 |
| South East Centreless Limited | Professional & scientific | 2025 |
| South West Bars Ltd | Hospitality | 2008 |
| South West London Dermatology Limited | Health & social care | 2024 |
| South West Professional Lettings Ltd | Real estate | 2018 |
| Southtech Utilities Ltd | Construction | 2023 |
| Sowhat Intelligence Ltd | Information & communication | 2026 |
| Soya World Limited | Wholesale & retail | 2017 |
| SP9 Holdings Limited | Administrative & support | 2021 |
| Spanish Algarve Properties Ltd | Real estate | 2003 |
| Spanlite International Limited | Administrative & support | 2005 |
| Sparca Limited | Professional & scientific | 2014 |
| SPB Management Ltd | Professional & scientific | 2016 |
| Special Logistics Limited | Transport & logistics | 2015 |
| Specialist Lift Services Limited | Manufacturing | 2000 |