| Start Lighting Limited | Other services | 2019 |
| Start Studio Ltd | Wholesale & retail | 2024 |
| Start-Work-Today Limited | Administrative & support | 2009 |
| Station 151 TCC Ltd | Wholesale & retail | 2025 |
| Steadfast Labour Solutions Ltd | Administrative & support | 2025 |
| Steart House (Burnham-On-Sea) Management Company Limited | Households | 1979 |
| Steel Gang UK Ltd | Construction | 2019 |
| Stefan Alexandru Logistics Ltd | Transport & logistics | 2025 |
| Stella Tracy Property Company Ltd | Real estate | 2019 |
| Step Forward Community CIC | Education | 2026 |
| Steph FOX Ltd | Professional & scientific | 2025 |
| Stephen & Co Block Management Ltd | Real estate | 2018 |
| Stephen & Co Secretarial Ltd | Households | 2020 |
| Stephen Laffan Services Limited | Professional & scientific | 2011 |
| Sterling Shine Cleaning Ltd | Administrative & support | 2026 |
| Steven Hardy Ltd | Real estate | 2025 |
| Steven Winfield Building & Tiling Ltd | Construction | 2021 |
| Sticks IT Consultancy Ltd | Information & communication | 2023 |
| Stone & Mason Build Ltd | Construction | 2026 |
| Stone Maritime Services Ltd | Manufacturing | 2026 |
| Stonecraft Builders SW Ltd | Real estate | 2016 |
| Stoneleigh Residential Care Home Limited | Health & social care | 2006 |
| Stonetree Joinery Ltd | Extraterritorial | 2019 |
| Storage SID Limited | Transport & logistics | 2025 |
| Store Here Ltd | Extraterritorial | 2020 |
| Stories of Amore Limited | Information & communication | 2019 |
| Storvik FM Limited | Administrative & support | 2018 |
| Storyhive Ltd | Information & communication | 2013 |
| Stourcastle Ltd | Professional & scientific | 2025 |
| Straight Eight International Ltd | Professional & scientific | 2013 |
| Stratton House Management (Weston) Limited | Households | 1981 |
| Strawberry View Management Limited | Construction | 2025 |
| Stribs Electrical Ltd | Construction | 2024 |
| Strike Communications Ltd | Professional & scientific | 2019 |
| Strongbox Cabinets Limited | Manufacturing | 2018 |
| Struct Applications Ltd | Information & communication | 2019 |
| Stuart Cardwell Ltd | Professional & scientific | 2003 |
| Stuco Transport Ltd | Transport & logistics | 2019 |
| Studio 63 Architecture Ltd | Professional & scientific | 2019 |
| Style the Venue Ltd | Administrative & support | 2026 |
| Subcontractee Limited | Administrative & support | 2024 |
| Subnetro Limited | Information & communication | 2020 |
| Subtleti Ventures Ltd | Wholesale & retail | 2025 |
| SUE Marsh Limited | Manufacturing | 2021 |
| Summis Global Ltd | Information & communication | 2014 |
| Summis Global Training Ltd | Administrative & support | 2022 |
| Sunflower Land Services Limited | Professional & scientific | 2014 |
| Sunnyside Incorporated Limited | Wholesale & retail | 1997 |
| Sunrise BBK Ltd | Wholesale & retail | 2019 |
| Sunrise WSM Ltd | Wholesale & retail | 2016 |
| Sunset Retail Services Ltd | Professional & scientific | 2020 |
| Super Deal Automotive Ltd | Wholesale & retail | 2025 |
| Super Fusion Limited | Hospitality | 2017 |
| Super Kitchen Supermare Ltd | Hospitality | 2026 |
| Super Mare Go and Grab Ltd | Wholesale & retail | 2025 |
| Superfoods Nutrition Ltd | Manufacturing | 2018 |
| Supermaps Ltd | Professional & scientific | 2019 |
| Surecy Ltd | Information & communication | 2016 |
| Surround Support Limited | Health & social care | 2020 |
| Surveyance Limited | Construction | 2018 |
| Surviral Ltd | Extraterritorial | 2020 |
| Sushant Limited | Health & social care | 2012 |
| Sustainable Gardens UK Limited | Extraterritorial | 2022 |
| Svendborg Consultancy Group 1892 Ltd | Professional & scientific | 2018 |
| SVN Consultancy Limited | Financial services | 2018 |
| SVP Systems Limited | Information & communication | 2022 |
| SVR Weight & Balance Consultancy Ltd | Professional & scientific | 2023 |
| Swallo Drinks EU Ltd | Professional & scientific | 2012 |
| Sweeney Dogs Weston Super Mare Limited | Other services | 2023 |
| Sweeping Solutions Limited | Wholesale & retail | 2004 |
| Sweet Surveys Ltd | Construction | 2023 |
| Sweetland Electrical Services Ltd | Construction | 2022 |
| Swift Electrics SW Ltd | Construction | 2021 |
| Swift Heat Pumps Limited | Construction | 2013 |
| Swift Home (SW) Ltd | Construction | 2019 |
| Switch Electrical Solutions Ltd | Construction | 2019 |
| Swsc Limited | Arts & recreation | 2014 |
| Syed Ahmed 786 Ltd | Wholesale & retail | 2018 |
| Synergy Advisory Services Ltd | Professional & scientific | 2019 |
| Synergy Networking Group Limited | Other services | 2021 |
| System Clenz Limited | Administrative & support | 2017 |
| T & L Wholesale Ltd | Wholesale & retail | 2021 |
| T & S Advertising Limited | Professional & scientific | 2012 |
| T & S Beardshaw Limited | Hospitality | 2005 |
| T & T Healthcare Ltd. | Health & social care | 2015 |
| T & V Associates Limited | Professional & scientific | 2013 |
| T Kelly Modeling Agency Ltd | Arts & recreation | 2021 |
| T&D Autos WSM Ltd | Wholesale & retail | 2024 |
| T&H-81 Estate Ltd | Real estate | 2023 |
| T&Tc Limited | Health & social care | 2014 |
| T.D.C (Somerset) Ltd | Professional & scientific | 2022 |
| T.E.S.A. (Western) Limited | Administrative & support | 1974 |
| T.E.S.A. Hvac Limited | Professional & scientific | 2005 |
| T.T.S. Truck Tyre Specialists Limited | Manufacturing | 1978 |
| T.W. Financing Limited | Manufacturing | 1987 |
| T9 Fire Systems Ltd | Administrative & support | 2026 |
| TAC TAC Ltd | Transport & logistics | 2022 |
| Tacc Consulting Limited | Professional & scientific | 2024 |
| Tacit Consultants Ltd | Administrative & support | 2012 |
| Taelon Ltd | Construction | 2024 |