| Sandtoft Developments Limited | Extraterritorial | 1992 |
| Sandymount Green Ltd | Real estate | 2006 |
| Sapphireedge Systems Ltd | Wholesale & retail | 2025 |
| SAT Business Travel Holdings Limited | Financial services | 2006 |
| Saville Town Properties Limited | Hospitality | 1993 |
| Savvy Marketing Limited | Professional & scientific | 2007 |
| SB Wakefield Limited | Wholesale & retail | 2004 |
| Scaffolding Access Solutions Limited | Construction | 2005 |
| Scala Consulting Limited | Professional & scientific | 2001 |
| Scalakids Limited | Arts & recreation | 2003 |
| Scat Plant Limited | Construction | 2005 |
| Scientific Games International Holdings Ltd | Arts & recreation | 2002 |
| SCS Projects Limited | Construction | 2007 |
| SDB Investments Limited | Professional & scientific | 2009 |
| Seabrook Group Limited | Manufacturing | 2006 |
| Sean Custance Master Butchers Limited | Wholesale & retail | 2002 |
| Sean Emmett Limited | Other services | 2002 |
| Sean Wilson Racing Limited | Wholesale & retail | 2006 |
| Seathorne Arms Limited | Hospitality | 2007 |
| Secure Utility Engineering Ltd. | Construction | 2007 |
| Seddon Manufacturing Limited | Manufacturing | 2000 |
| SEE More Travel Limited | Administrative & support | 2005 |
| Seed Bros. (Investments) Limited | Real estate | 1979 |
| Sekhon & Firth LLP | | 2005 |
| Serenegrade Limited | Construction | 1978 |
| Settan Limited | Construction | 2004 |
| SFL (Yorkshire) Limited | Administrative & support | 2006 |
| Shabab Restaurant (Harrogate) Limited | Hospitality | 1984 |
| Shadow IT Consulting Limited | Information & communication | 2006 |
| Shahjalal Enterprise Ltd | Administrative & support | 2021 |
| Shakesbeer Limited | Hospitality | 2006 |
| Shalom Osher LLP | | 2025 |
| Shans Supermarkets Limited | Wholesale & retail | 2006 |
| Share Dealing Nominees Limited | Extraterritorial | 1991 |
| Sharp Cutters Limited | Manufacturing | 1987 |
| Shaw Dale & Company Limited | Construction | 1992 |
| Sheard Design Limited | Arts & recreation | 2006 |
| Shelagh O'Leary Ltd | Administrative & support | 2012 |
| Shelf Pharmacy Limited | Health & social care | 2003 |
| Shellon Engineering Limited | Professional & scientific | 2009 |
| Sheridan Court (Leeds) Limited | Administrative & support | 1995 |
| Sheridons Insurance, Mortgage and Finance Consultants Limited | Professional & scientific | 1982 |
| Sherwood Coatings Limited | Manufacturing | 1989 |
| Shield Security (UK) Limited | Administrative & support | 2003 |
| Shimla Spice Restaurant Limited | Hospitality | 1997 |
| SHOPPING4U Ltd | Wholesale & retail | 2020 |
| Short Circuits Care Club Limited | Other services | 2004 |
| Shubham Consultancy Ltd | Information & communication | 2016 |
| Shubhangi Limited | Information & communication | 2004 |
| Sidda Trading London Ltd | Manufacturing | 2020 |
| Siddique Pharmacy Limited | Wholesale & retail | 2001 |
| Sight Airedale | Health & social care | 1999 |
| Silchrome Plating Limited | Manufacturing | 1996 |
| Simon Barnes Plumbing Limited | Construction | 2007 |
| Simon's Decorations Limited | Construction | 2003 |
| Simpla Systems Limited | Transport & logistics | 1987 |
| Simpson`S Electrical Services Limited | Construction | 2003 |
| Sizetask Limited | Information & communication | 2002 |
| SJP Joinery Ltd | Construction | 2018 |
| Skillmanor Limited | Households | 1980 |
| Skills With Frills Education Ltd. | Education | 2017 |
| Skipping School Ltd | Arts & recreation | 2007 |
| Skipton Snooker and Leisure Limited | Arts & recreation | 1999 |
| Sky D.I.Y. Supercentre Limited | Wholesale & retail | 2003 |
| Skyblazers Fireworks Limited | Other services | 1998 |
| Skyward Path Ltd | Wholesale & retail | 2025 |
| Sloan & Davidson Limited | Professional & scientific | 1992 |
| Small Green PEA Ltd | Wholesale & retail | 2006 |
| Smart LAB Limited | Information & communication | 2004 |
| Smart Security UK Limited | Construction | 2006 |
| Smawthorne Community Project | Other services | 2001 |
| SMB Direct Ltd | Wholesale & retail | 2018 |
| SMC International Holdings Limited | Administrative & support | 1995 |
| SMG Commercial Limited | Hospitality | 2023 |
| SMG Legal Limited | Professional & scientific | 2006 |
| Smith Bros. Decorators Limited | Construction | 2005 |
| Smithson & Littlewood Limited | Manufacturing | 2000 |
| Snaithing Properties Limited | Health & social care | 1999 |
| Snowgate Investments Limited | Construction | 2001 |
| So...Change Limited | Information & communication | 2006 |
| Solden (1947) Limited | Real estate | 1980 |
| Solotrim Limited | Construction | 1977 |
| Sound Leisure Limited | Manufacturing | 1977 |
| Sound Trading Limited | Hospitality | 2003 |
| Sourcedbymd Limited | Construction | 2020 |
| Southgate Lighting Limited | Construction | 1992 |
| Southreed Limited | Transport & logistics | 1987 |
| Sowerby Bridge Wharf Limited | Real estate | 1998 |
| Sparkijone Partners Ltd | Wholesale & retail | 2025 |
| Spauls & Sons (Butchers) Limited | Wholesale & retail | 2007 |
| Specialist Vehicle Sourcing & Finance Solutions Ltd | Wholesale & retail | 2018 |
| Spectrum Powder Coatings Limited | Professional & scientific | 2003 |
| Speedstyle (UK) Limited | Wholesale & retail | 2004 |
| Spenborough Abattoir Limited | Wholesale & retail | 1982 |
| Spencer and Broadhead Limited | Wholesale & retail | 1980 |
| Spencer Shopfitters & Joiners Limited | Construction | 2007 |
| Sphere 43 Limited | Professional & scientific | 2001 |
| Spinning Top Childcare Limited | Health & social care | 2003 |
| Sponge Music Limited | Information & communication | 2004 |
| Sport-Business-Performance Ltd | Professional & scientific | 2004 |