| Salaam Medical Services Limited | Health & social care | 2012 |
| Sales Team Solutions Ltd | Administrative & support | 2004 |
| Salford Metals Limited | Wholesale & retail | 2007 |
| Salisbury Jones Limited | Wholesale & retail | 1979 |
| Sally Wood Photography Limited | Other services | 2007 |
| Samcoeu Ltd | Wholesale & retail | 2021 |
| Samson Recycling Limited | Water & waste | 2021 |
| Samuel Groves & Co.Limited | Extraterritorial | 1917 |
| SAN Remo Records Limited | Information & communication | 2006 |
| Sanbiz Limited | Wholesale & retail | 2021 |
| Sanderson Property Developments Limited | Real estate | 1998 |
| Sanderson Services UK Limited | Other services | 2006 |
| Sandvik Disability Trust Limited | Other services | 1996 |
| Sandvik Hard Materials | Manufacturing | 1940 |
| Sandvik Holdings Limited | Professional & scientific | 1993 |
| Sandvik Mining and Construction Limited | Wholesale & retail | 1989 |
| Sandwell and District West Indian Community Association | Education | 1998 |
| Sandwell Financial Advisers Limited | Extraterritorial | 1994 |
| Sandwell Park Golf Club Limited | Hospitality | 1946 |
| Sandwell Young Carers | Health & social care | 1999 |
| SANDY22 Ltd | Health & social care | 2022 |
| Sanford Barnes Limited | Administrative & support | 2001 |
| Sapphire Group Care Home Ltd | Health & social care | 2019 |
| Sarah's Rose Garden Limited | Wholesale & retail | 2003 |
| Sarah-Jane Fishing Limited | Agriculture & fishing | 1997 |
| Sarai Limited | Wholesale & retail | 2012 |
| Sarea Trading Company Limited | Wholesale & retail | 2023 |
| Saul Convenience Limited | Wholesale & retail | 2002 |
| Saunders Industrial Systems Limited | Manufacturing | 2023 |
| Scordis (Payroll) Limited | Professional & scientific | 2015 |
| Scorpion Autos Ltd | Wholesale & retail | 2004 |
| Scot Young Research Limited | Manufacturing | 1950 |
| Scraptoft Hall Limited | Real estate | 2007 |
| Seafish Sutton Limited | Hospitality | 2003 |
| Seagull Fittings Limited | Wholesale & retail | 1993 |
| SEC Services (UK) Limited | Manufacturing | 2004 |
| Section Roll & Tools Limited | Manufacturing | 2007 |
| Secure IT ALL Limited | Administrative & support | 1995 |
| Secure Services UK Limited | Administrative & support | 2007 |
| Security Products UK Limited | Extraterritorial | 1978 |
| Security Warehouse Limited | Wholesale & retail | 2007 |
| Sedgley Glass Limited | Construction | 2005 |
| Sedgley Road Aquarium Limited | Wholesale & retail | 2005 |
| Sega Supplies Limited | Wholesale & retail | 2000 |
| Select Lettings Limited | Professional & scientific | 1998 |
| Select Property Management Limited | Real estate | 1998 |
| Semloh Refurbishment and Joinery Contractors Limited | Construction | 1998 |
| Senator System Consultants Ltd | Information & communication | 1998 |
| Senex Limited | Real estate | 2002 |
| Sennabuild Ltd | Construction | 2000 |
| Seranova Care Group Limited | Health & social care | 2026 |
| Serck Industrial Limited | Administrative & support | 2005 |
| SET and Match Limited | Manufacturing | 1992 |
| Seth Homes Limited | Health & social care | 2004 |
| Sewage & RBC Solutions Ltd | Professional & scientific | 2007 |
| SG Dighton Limited | Professional & scientific | 2001 |
| SH Constructions Services Limited | Construction | 2026 |
| Shadowwallet Ltd | Transport & logistics | 2020 |
| Shafqat Property Holdings Limited | Real estate | 2017 |
| Shaikh Global Commerce Ltd | Wholesale & retail | 2025 |
| Shale Street Autos Ltd | Wholesale & retail | 2019 |
| Shanakul Limited | Hospitality | 1999 |
| Shandong Grest Ltd | Manufacturing | 2023 |
| Shandong Jinbaicheng Metal Materials Co., Ltd | Extraterritorial | 2023 |
| Shandong Qingdao Sino Steel Co., Limited | Extraterritorial | 2024 |
| Shandong Quantong Metal Products Co., Ltd. | Extraterritorial | 2023 |
| Shandong Xinchuangying Ltd | Manufacturing | 2023 |
| Share Schemes Limited | Professional & scientific | 2025 |
| Shavron Enterprises Ltd | Wholesale & retail | 2018 |
| SHD Trading Co., Limited | Wholesale & retail | 2023 |
| Shellbie Ltd | Construction | 2007 |
| Shelley Consultancy Limited | Information & communication | 2002 |
| Shenley Green Surgery Limited | Health & social care | 2002 |
| Shenzhen Jiumu Intelligent Technology Co., Ltd | Manufacturing | 2023 |
| Shenzhen Zhiyan Precision Technology Co., Ltd | Manufacturing | 2023 |
| Shifang Tree Limited | Wholesale & retail | 2023 |
| Shinehill (Assets) Limited | Professional & scientific | 1973 |
| Shineway Technology Co., Ltd | Manufacturing | 2026 |
| Shinz Properties Limited | Wholesale & retail | 2018 |
| Shipley & Sons (Amusements) Limited | Arts & recreation | 1961 |
| Shire Oak Investments (UK) Limited | Real estate | 2006 |
| Shire Oak Rentals Ltd | Real estate | 2023 |
| Shire Property Services (Central) Limited | Real estate | 1999 |
| Shireland Learning Limited | Education | 2007 |
| Shockwave Pyrotechnics Ltd | Arts & recreation | 1963 |
| Shore Properties Limited | Construction | 2003 |
| Shurgrove Limited | | 1986 |
| Sian Stores Limited | Wholesale & retail | 2006 |
| Siaram Consulting Limited | Information & communication | 2007 |
| Sideview Property Maintenance Ltd | Construction | 2021 |
| Sidhu's Limited | Wholesale & retail | 2000 |
| Sidney Smith Castings Limited | Manufacturing | 1996 |
| Sigma Labtek Limited | Extraterritorial | 2023 |
| Sigmatek Europe Limited | Administrative & support | 1997 |
| Signature Retreat Limited | Other services | 2017 |
| Signforce Outdoor Advertising Limited | Arts & recreation | 1999 |
| Signform Limited | Administrative & support | 2003 |
| Silexine Coatings Limited | Construction | 2001 |
| Silva Stsms Ltd | Administrative & support | 2016 |
| Simbolon Limited | Administrative & support | 2005 |