| DR. Faiza Ansari Ltd | Health & social care | 2023 |
| Dragon Kitchen Ltd | Hospitality | 2019 |
| Drakestown Properties Ltd. | Real estate | 1984 |
| Dream Homes Midland Ltd | Construction | 2026 |
| Dream Live Achieve Academy C.I.C. | Arts & recreation | 2020 |
| Drinkss Limited | Wholesale & retail | 2017 |
| Drivegreg Ltd | Other services | 2020 |
| Drivers Education Limited | Education | 2026 |
| Driveruk Ltd | Transport & logistics | 2018 |
| Driveway Restoration Ltd | Construction | 2022 |
| Driving 24-7 Ltd | Transport & logistics | 2019 |
| Driving School Automatic Ltd | Education | 2021 |
| Drivique Ltd | Transport & logistics | 2025 |
| DRK Technologies Limited | Information & communication | 2020 |
| Drury Casement Co. Limited(The) | Construction | 1958 |
| DS Auto Ltd | Wholesale & retail | 2022 |
| DS97 Holdings Ltd | Professional & scientific | 2023 |
| DSA Intelligence Limited | Professional & scientific | 2017 |
| Dsaw Ltd | Information & communication | 2020 |
| Dscolar Limited | Transport & logistics | 2026 |
| DSG247 Logistics Ltd | Transport & logistics | 2024 |
| DSK Services (Midlands) Ltd | Transport & logistics | 2023 |
| DSL Recording Company Ltd | Information & communication | 2021 |
| DSM Logistic Midlands Ltd | Transport & logistics | 2023 |
| DSS Midlands Limited | Construction | 2022 |
| DT Attendance Consultancy Limited | Education | 2018 |
| Dtec Manufacturing Ltd | Manufacturing | 2013 |
| DTS Bookkeeping Ltd | Professional & scientific | 2025 |
| Dubble J Ltd | Real estate | 2024 |
| Duct Pro Ltd | Manufacturing | 2025 |
| Dudley Factory Doors Limited | Extraterritorial | 1998 |
| Duhele Construction Limited | Construction | 2024 |
| Dulay Properties Ltd | Real estate | 2020 |
| Dunn Tasty Jerk Ltd | Hospitality | 2020 |
| Dunya West Bromwich Ltd | Wholesale & retail | 2025 |
| Durja Associates Ltd | Professional & scientific | 2017 |
| Durma Ltd | Wholesale & retail | 2024 |
| DWH Projects Ltd | Professional & scientific | 2023 |
| Dylan Gill Ltd | Construction | 2024 |
| Dynamic Engineering UK Limited | Manufacturing | 2008 |
| Dynamic Kids CIC | Education | 2022 |
| Dynatech Engineering Ltd | Manufacturing | 1997 |
| E & a Freight Ltd | Transport & logistics | 2023 |
| E & R Retail Ltd | Wholesale & retail | 2025 |
| E a Plus Ltd | Wholesale & retail | 2021 |
| E T & H Logistics Limited | Transport & logistics | 2017 |
| E W Turner and Company Limited | Manufacturing | 1998 |
| E-Buy PVT Ltd | Wholesale & retail | 2022 |
| E-Logistix Ltd | Transport & logistics | 2016 |
| Eagle Courier Services Ltd | Transport & logistics | 2021 |
| Eardoc Ltd | Health & social care | 2023 |
| Early Years Birmingham Limited | Health & social care | 2025 |
| Earston Trading Limited | Professional & scientific | 2025 |
| Earthly Elements Limited | Wholesale & retail | 2025 |
| Easington Associates Limited | Professional & scientific | 2015 |
| East END Foods Holdings Limited | Wholesale & retail | 2011 |
| East END Foods Properties Limited | Real estate | 2011 |
| Easy Fulfilment UK Limited | Information & communication | 2020 |
| Ebanks Holding Limited | Financial services | 2023 |
| Ebike FIX Ltd | Wholesale & retail | 2025 |
| Ecclesia Events Ltd | Real estate | 2025 |
| Echoes EAR Health & Wellbeing Limited | Health & social care | 2025 |
| Eco Build Solutions Ltd | Construction | 2025 |
| Eco Plus Limited | Construction | 2019 |
| Eco Power Installs Limited | Construction | 2023 |
| Eco Vision Midlands Ltd | Financial services | 2024 |
| Econ Selection Limited | Professional & scientific | 2001 |
| Ecopledge Ltd | Manufacturing | 2026 |
| Ecosikhuk Community Interest Company | Professional & scientific | 2020 |
| Ecotrash Domestic & Commercial Waste Clearance Limited | Water & waste | 2025 |
| Ecovance Ltd | Construction | 2025 |
| Ed-Ar Transport Ltd | Transport & logistics | 2015 |
| Eden G Lettings Limited | Real estate | 2025 |
| Eder Holding Limited | Financial services | 2024 |
| Eder Investment Group Limited | Financial services | 2024 |
| Eder Trade Ltd | Construction | 2023 |
| Edgar's Hair Company Limited | Administrative & support | 2017 |
| Edgbaston TMS Ltd | Transport & logistics | 2026 |
| Edge Living T/A Furniture World Ltd | Wholesale & retail | 2018 |
| Edmento Limited | Education | 2024 |
| EDU Archives Ltd | Administrative & support | 2024 |
| Educate 2 Empower | Education | 2016 |
| Edward Tudor Limited | Wholesale & retail | 2026 |
| Edwards Properties Development Ltd | Construction | 2025 |
| Efixtec Ltd | Information & communication | 2016 |
| EG Electrical Guardian Ltd | Manufacturing | 2020 |
| Eggfree Cake Box West Bromwich Limited | Hospitality | 2014 |
| EHG Digital Ltd | Information & communication | 2025 |
| Ehster-Sam Care Ltd | Health & social care | 2020 |
| Eight Peaks Dine Ltd | Hospitality | 2023 |
| Ekam Properties Ltd | Construction | 2021 |
| EKS Midland Ltd | Hospitality | 2025 |
| Ekseva Ltd | Manufacturing | 2025 |
| El-Roi LUX Hairs Ltd | Other services | 2025 |
| Eleanathelia Ltd | Health & social care | 2020 |
| Electro Heat Treatments Limited | Professional & scientific | 1952 |
| Electrobase Ltd | Construction | 2018 |
| Elektrovolt Ltd | Construction | 2014 |
| Eliora Ventures Limited | Construction | 2026 |
| Elite Booths Ltd | Information & communication | 2021 |