| Soncom Ltd | Real estate | 2019 |
| Soni Jewellers Limited | Wholesale & retail | 2015 |
| Sonic Infotech Solutions Ltd | Information & communication | 2023 |
| Soos Drink Ltd | Wholesale & retail | 2021 |
| Sophia Events Ltd | Hospitality | 2023 |
| Sophia HA Ltd | Education | 2025 |
| Sophie Khosravani Ltd | Health & social care | 2023 |
| Soso 2008 Ltd | Hospitality | 2023 |
| Soteria AI Limited | Information & communication | 2018 |
| Soulphysio Health and Care. Ltd | Health & social care | 2025 |
| Sound Nook Limited | Real estate | 2024 |
| Sounds & Surveillance Systems Limited | Construction | 2005 |
| Sourcecore Solutions Limited | Wholesale & retail | 2025 |
| South Eastern Interiors Limited | Manufacturing | 2007 |
| South London Steel Limited | Professional & scientific | 2011 |
| South Meadows (Wembley) Limited | Households | 1965 |
| South UK Foods Ltd | Hospitality | 2022 |
| South UK Thai Food Ltd | Hospitality | 2024 |
| Southern Caterers Ltd | Hospitality | 2020 |
| Southway Garage Services Ltd | Wholesale & retail | 2019 |
| Southwest Services and Solutions Ltd | Wholesale & retail | 2023 |
| Sova Property Ltd | Real estate | 2020 |
| Sovereign 11 Limited | Construction | 2017 |
| Sovereign Service Solutions Ltd | Professional & scientific | 2026 |
| SP Brothers Ltd | Wholesale & retail | 2025 |
| SP ERP Services Ltd | Information & communication | 2013 |
| SP Logistics Solutions Limited | Wholesale & retail | 2019 |
| SP Technologies PVT Limited | Information & communication | 2019 |
| SP UK Retail Limited | Wholesale & retail | 2025 |
| SP Wash Limited | Other services | 2025 |
| Space 2 Build London Ltd | Construction | 2017 |
| Spaceflow International Limited | Information & communication | 2018 |
| Spacewave Consulting Ltd | Professional & scientific | 2023 |
| Spar Properties London Limited | Financial services | 2025 |
| Spark Bright Stem Limited | Education | 2026 |
| Spark Master Electrical Ltd | Construction | 2023 |
| Sparkle Grace Consultancy Limited | Professional & scientific | 2022 |
| Sparkling & Shining Cleaning Services Limited | Administrative & support | 2024 |
| Sparks and Concepts Ltd | Professional & scientific | 2024 |
| Spartacus CVO Ltd | Wholesale & retail | 2024 |
| SPB 24 Limited | Health & social care | 2021 |
| SPB BUY2LET Properties Ltd | Real estate | 2019 |
| SPB Events Limited | Hospitality | 2023 |
| Spdigitaltrade Limited | Wholesale & retail | 2025 |
| Spdp Services Ltd | Construction | 2025 |
| Specialist Team Ltd | Construction | 2023 |
| Spectocular Limited | Health & social care | 2019 |
| Spectrum Trading PVT Ltd | Wholesale & retail | 2015 |
| Speech Language & Communication Therapy Limited | Health & social care | 2020 |
| Speeds Auto Ltd | Wholesale & retail | 2024 |
| Speedy Lettings Ltd | Information & communication | 2016 |
| Spellbound From England Ltd | Wholesale & retail | 2014 |
| Spher International Ltd | Other services | 2013 |
| Sphiita Limited | Information & communication | 2012 |
| Sphinx Training Limited | Education | 2018 |
| Spic and Span Cleaners Limited | Administrative & support | 2011 |
| Spice Junkies Ltd | Hospitality | 2025 |
| Spiceroute International Limited | Agriculture & fishing | 2026 |
| Spiceshine Ltd | Wholesale & retail | 2026 |
| Spicom Trading Ltd | Wholesale & retail | 2018 |
| Spicy Chatkara Ltd | Hospitality | 2026 |
| Spicy Food Bowl Ltd | Hospitality | 2025 |
| Spicy Pictures Ltd | Hospitality | 2013 |
| Spiky Unisex Salon Ltd | Other services | 2026 |
| Spinnaker Global Advisors Ltd | Professional & scientific | 2025 |
| Spinverse Events Ltd | Arts & recreation | 2025 |
| Spirit in Stirrups Limited | Professional & scientific | 2013 |
| Spirit of Britain Limited | Wholesale & retail | 2019 |
| SPJ Finance Ltd | Construction | 2018 |
| SPK Capital Limited | Hospitality | 2021 |
| Splash Pictures Ltd | Information & communication | 2018 |
| Splenteur Ltd | Wholesale & retail | 2025 |
| SPN Craft Ltd | Manufacturing | 2021 |
| SPN Leisure Limited | Hospitality | 2022 |
| Spocsoft Limited | Real estate | 2006 |
| Spontane Limited | Information & communication | 2026 |
| Sport Street Social Ltd | Wholesale & retail | 2021 |
| Sporting Opportunities for ALL Limited | Arts & recreation | 2005 |
| Sporting the Youth Limited | Health & social care | 2013 |
| Sportoni Ltd | Wholesale & retail | 2020 |
| Sports Bar Wembley Limited | Hospitality | 2025 |
| Sports Marketing Limited | Wholesale & retail | 2019 |
| Spot on Vehicle Management Ltd | Administrative & support | 2013 |
| Spring Gold (UK) Limited | Financial services | 2016 |
| Springwood Real Estate Limited | Real estate | 2022 |
| Sprint Services Limited | Administrative & support | 2017 |
| SPS Services Limited | Administrative & support | 2023 |
| SPT Transport Ltd | Transport & logistics | 2017 |
| Spuddy Buddies Ltd | Hospitality | 2025 |
| Spyde Ltd. | Information & communication | 2017 |
| SQD Trading Ltd | Wholesale & retail | 2021 |
| Square Direct Ltd | Information & communication | 2023 |
| SR 168 Ltd | Hospitality | 2025 |
| SR Cash and Carry Ltd | Wholesale & retail | 2025 |
| SR Claims Services Ltd | Administrative & support | 2022 |
| SR Consultants & Management Services Ltd | Administrative & support | 2013 |
| SR Consulting Group Limited | Information & communication | 2018 |
| SR DIU Ltd | Wholesale & retail | 2025 |
| Sr(Spv 1) Ltd | Real estate | 2018 |
| Srai Medical Ltd | Other services | 2025 |