| Snareobics Ltd | Information & communication | 2023 |
| Soloman Homer Ltd | Professional & scientific | 2018 |
| Somerglaze Windows Ltd | Construction | 2008 |
| Somerset Artists Limited | Arts & recreation | 2015 |
| Somerset Arts Well CIC | Education | 2019 |
| Somerset Building Services Ltd | Construction | 2018 |
| Somerset Forge Limited | Manufacturing | 1979 |
| Somerset Frames Limited | Wholesale & retail | 2017 |
| Somerset Prestige Cars Ltd | Wholesale & retail | 2025 |
| Somerset Property Services Ltd | Real estate | 2022 |
| Somerset Tourism Association Community Interest Company | Administrative & support | 2009 |
| Somerset Vehicle Services Ltd | Wholesale & retail | 2019 |
| Somerset Worktops Ltd | Extraterritorial | 2014 |
| Sophie Clapham Consulting Ltd | Administrative & support | 2013 |
| Soteria Properties Ltd | Real estate | 2025 |
| Soteria Roofing Ltd | Construction | 2020 |
| Soufla Ltd | Health & social care | 2021 |
| Soul Sessions (Somerset) Limited | Hospitality | 2026 |
| Soundmind Consulting Ltd | Administrative & support | 2025 |
| Sounds Joyful CIC | Health & social care | 2024 |
| South Bristol Service Centre Ltd | Wholesale & retail | 2015 |
| South West Flat Roofing SW Limited | Construction | 2025 |
| South West School Wear Ltd | Wholesale & retail | 2008 |
| South-West Fireplaces Limited | Construction | 2013 |
| Southernhay Living (South West) Limited | Professional & scientific | 2009 |
| Southtown Farm Ltd | Agriculture & fishing | 2012 |
| Southwood Naval Ltd | Professional & scientific | 2023 |
| Space Property Management Limited | Real estate | 2020 |
| Spaceinvader Ltd | Information & communication | 2025 |
| Spada International Limited | Financial services | 2016 |
| Spada Limited | Information & communication | 2016 |
| Sparkford Estates Investments Limited | Real estate | 2009 |
| Sparkford Estates Limited | Agriculture & fishing | 1956 |
| Sparkford Estates Trading Limited | Agriculture & fishing | 2009 |
| Sparkford Sawmills SW Limited | Manufacturing | 2011 |
| Specialist Earthing Services Ltd | Professional & scientific | 2024 |
| Spenn Stairlifts Ltd | Financial services | 2022 |
| SPG Technical Services Limited | Professional & scientific | 2016 |
| Spine Agency Ltd | Professional & scientific | 2019 |
| Spirit of Alderney Ltd | Wholesale & retail | 2025 |
| Spln Consultancy Ltd | Professional & scientific | 2025 |
| Sportesse International (UK) Limited | Administrative & support | 2002 |
| Spot on Truck Hire Ltd | Administrative & support | 2016 |
| Spot Wines Limited | Wholesale & retail | 2014 |
| Spudivor Designs Limited | Professional & scientific | 2017 |
| Spur Support Services Limited | Professional & scientific | 2019 |
| SSH Conservation Holdings Ltd | Financial services | 2022 |
| ST Andrews Press of Wells Ltd. | Manufacturing | 1998 |
| ST Bartholomews Court Management Limited | Households | 2015 |
| ST Cuthbert's Church of England Academy Infants and Pre-School | Education | 2012 |
| ST Cuthberts Holdings Limited | Professional & scientific | 2010 |
| ST Cuthberts Mill Limited | Manufacturing | 2010 |
| ST Lawrence Lodge Ltd | Extraterritorial | 2009 |
| ST Thomas Mews Management Limited | Households | 2005 |
| ST. Cuthberts Lodge Management Company Limited | Households | 1983 |
| Stacey Mcintosh Foundation | Information & communication | 2019 |
| Starbev Pubs Ltd | Hospitality | 2021 |
| Stayplay Resorts Ltd | Extraterritorial | 2022 |
| Stbuk Limited | Professional & scientific | 2014 |
| Steel's Agriculture & Forestry Ltd | Real estate | 2025 |
| Steem Foods Ltd | Extraterritorial | 2019 |
| Steve Gooch Ltd | Other services | 2020 |
| Stevens Agri-Engineering Limited | Agriculture & fishing | 2009 |
| Stevlyn Limited | Professional & scientific | 2001 |
| STG Music Ltd | Information & communication | 2008 |
| Stiling Civils Ltd | Construction | 2024 |
| Stoodly Enterprises Limited | Wholesale & retail | 2000 |
| Storywise Limited | Professional & scientific | 2009 |
| Street Properties LLP | | 2010 |
| Striving Limited | Professional & scientific | 2010 |
| Structural Geology Services: C K Morley Limited | Other services | 2022 |
| Stsw Limited | Professional & scientific | 2010 |
| Studio Eight Wells CIC | Health & social care | 2025 |
| Studio Fice Design Ltd | Professional & scientific | 2026 |
| Studio NO 23 Limited | Real estate | 2017 |
| Studio Stores Supplies Limited | Construction | 2025 |
| Studyhome 1992 Limited | Real estate | 1989 |
| Summa Cura Ltd | Health & social care | 2021 |
| Sunangel Imaging Limited | Manufacturing | 2015 |
| Sunnyside Fisheries Limited | Agriculture & fishing | 2018 |
| Sunnyspells Leisure Ltd | Real estate | 2016 |
| Sunshine Public Relations Ltd | Professional & scientific | 2011 |
| Super Stages Ltd | Administrative & support | 2003 |
| Surecav Limited | Manufacturing | 2003 |
| Sustainable Food Somerset Ltd | Education | 2001 |
| Sutcliffe & Co Limited | Professional & scientific | 1999 |
| Sutton Veny House Limited | Health & social care | 2003 |
| Suttons Stairlifts Limited | Other services | 2018 |
| SW Roofing Contractor (Wells) Ltd | Construction | 2026 |
| Swallowcliffe Interiors Ltd | Manufacturing | 2023 |
| Swan Legal Limited | Professional & scientific | 2021 |
| Swan Mill Developments Limited | Real estate | 2016 |
| Swift Laundry Limited | Other services | 2015 |
| Symms Fabrications Limited | Manufacturing | 2005 |
| T Clarke Farriery Ltd | Agriculture & fishing | 2018 |
| T Glover Electrical Ltd | Construction | 2020 |
| T S Automation Ltd | Construction | 2025 |
| T S Stevens Limited | Agriculture & fishing | 2003 |
| T. G. Blanchard Plant Limited | Construction | 2015 |
| T. Y. T Healthcare Ltd | Wholesale & retail | 2025 |