| Rhukit Manufacturing Ltd | Construction | 2011 |
| Richard ASH Horseshoes Ltd | Wholesale & retail | 2005 |
| Richard Jackson's Garden Limited | Extraterritorial | 2013 |
| Rick Francis Ltd | Professional & scientific | 2016 |
| Ring O'Bells Wookey Limited | Hospitality | 2019 |
| Rise Regulatory Consulting Ltd | Professional & scientific | 2024 |
| River Developments Limited | Real estate | 1995 |
| River Property Limited | Households | 2005 |
| Riverbed Limited | Administrative & support | 2005 |
| Riverside Horton Properties Limited | Construction | 2017 |
| Riviera Productions Ltd | Arts & recreation | 2023 |
| RJS Development Management Limited | Construction | 2020 |
| Robert Driver Transactional Services Ltd | Professional & scientific | 2019 |
| Rocket Masonry Limited | Construction | 2002 |
| Rocksteady Tents Ltd | Administrative & support | 2023 |
| Rocky Mountain Nursery Limited | Wholesale & retail | 2013 |
| Rococo Graphics Limited | Manufacturing | 2023 |
| Roderick Thomas Limited | Real estate | 2013 |
| Rodmore Farm Limited | Agriculture & fishing | 2017 |
| Rogers Restorations Limited | Construction | 2012 |
| Rookwood Operations Ltd | Manufacturing | 2022 |
| Rosa Medica Limited | Wholesale & retail | 1992 |
| Ross CAN Handy MAN Ltd | Construction | 2025 |
| Roundheads Limited | Real estate | 2021 |
| Rowena Estates Ltd | Real estate | 2026 |
| ROY Spicer Roofing Limited | Construction | 2002 |
| Rpal Solutions Ltd | Information & communication | 2004 |
| RSG Plumbing & Sons Ltd | Construction | 2023 |
| Ryan Ball Photography Limited | Professional & scientific | 2017 |
| S & D P Design Services Limited | Real estate | 1972 |
| S & KAY Properties Ltd | Real estate | 2021 |
| S a Burdett Limited | Transport & logistics | 2003 |
| S J Westmacott Limited | Construction | 2005 |
| S. Morfey Consultancy Limited | Professional & scientific | 2022 |
| Sadlers Restaurant Ltd | Hospitality | 2025 |
| Safe & Sound Homecare Services (Street) Ltd | Health & social care | 2020 |
| Saffa Distribution Ltd | Wholesale & retail | 2023 |
| Sahko Electrical Services Limited | Construction | 2025 |
| SAL Courier Ltd | Transport & logistics | 2025 |
| Salmon Planning Company Limited | Professional & scientific | 2003 |
| Samari Limited | Health & social care | 2014 |
| Samba DO Bispo CIC | Education | 2024 |
| Samkhat Advisory Ltd | Professional & scientific | 2013 |
| Samkhat Ltd | Financial services | 1999 |
| Sanctuary Developments Limited | Construction | 2012 |
| Sandu Site Solutions Limited | Construction | 2017 |
| Sara Harris Coaching Limited | Arts & recreation | 2025 |
| Satis Consulting Limited | Construction | 2015 |
| Sbaw Group Limited | Professional & scientific | 2006 |
| SCA Classic Holdings Ltd | Financial services | 2025 |
| Schoolhouse Developments Ltd. | Construction | 2001 |
| Schoolhouse Property Ltd. | Extraterritorial | 2003 |
| Scream MAX Studios Ltd | Professional & scientific | 2023 |
| Scuba Blue Ltd | Arts & recreation | 2018 |
| Searchlight Terrier Development (STD) Ltd | Information & communication | 2020 |
| Seedling Brands Limited | Wholesale & retail | 2019 |
| Seeways Limited | Information & communication | 2020 |
| Sellcom Ltd | Information & communication | 2011 |
| Serious Fabrication Limited | Manufacturing | 2021 |
| Serious Film Stages Ltd | Manufacturing | 2020 |
| Serious Global Limited | Financial services | 2016 |
| Serious Holdings Limited | Arts & recreation | 1984 |
| Serious International Ltd. | Financial services | 2015 |
| Serious Sound Stage Ltd | Manufacturing | 2020 |
| Serious Stages Limited | Manufacturing | 2001 |
| Serious Studios Limited | Extraterritorial | 2021 |
| Serious Ventures Limited | Administrative & support | 2004 |
| Shaded Music Ltd | Information & communication | 2026 |
| Shane Johnson Ltd | Construction | 2012 |
| Sheen Services 1988 Ltd | Administrative & support | 2025 |
| Sheppard Design Limited | Construction | 2012 |
| Shepton Brewing Company Limited | Hospitality | 2015 |
| Shepton Mallet (Phase 7) Management Company Limited | Households | 2014 |
| Shepton Mallet AFC Limited | Arts & recreation | 1986 |
| Shift DC LLP | | 2011 |
| Shift Design Consultants Limited | Professional & scientific | 2026 |
| Shoemaster International Ltd. | Information & communication | 1996 |
| Shrewsbury Prison Ltd | Construction | 2015 |
| Shrubbery Hotel (2013) Limited | Hospitality | 2013 |
| Sign & Design (Somerset) Ltd | Professional & scientific | 2013 |
| Simmons Accountants Limited | Professional & scientific | 1998 |
| Simon Dennis Ltd | Energy | 2015 |
| Simon King Wildlife Limited | Professional & scientific | 2005 |
| Simon North Associates Ltd. | Professional & scientific | 2003 |
| Simply Property Management Company Limited | Real estate | 2002 |
| Simply Technology Limited | Administrative & support | 2018 |
| Singleton Court Management Company (Wells) Limited | Households | 1991 |
| Site Supervising Solutions Ltd | Construction | 2024 |
| SIX Twenty SIX Ltd | Financial services | 2022 |
| SJL Data Services Ltd | Information & communication | 2020 |
| Slinkytronic Ltd | Professional & scientific | 2014 |
| SLP Interiors Limited | Construction | 2014 |
| Small Down Limited | Financial services | 2023 |
| Smart Auto Body Ltd | Wholesale & retail | 2025 |
| Smart Build Southwest Ltd | Construction | 2020 |
| Smarter Resourcing Ltd | Professional & scientific | 2004 |
| Smartlife Ltd. | Education | 1999 |
| SMF Rose Ltd | Administrative & support | 2025 |
| Smith Servicing Ltd | Wholesale & retail | 2006 |
| SMS Station Motor Services Ltd | Administrative & support | 2010 |