| Dolce Mila Ltd | Manufacturing | 2015 |
| Dolphin & Sons Car Sales Ltd | Wholesale & retail | 2016 |
| DOMENAK9 Ltd | Administrative & support | 2020 |
| Domestic Electrical Contractors Ltd | Construction | 2017 |
| Dominion Consultancy Group Ltd | Administrative & support | 2021 |
| Dominion Excel Limited | Real estate | 2020 |
| DOSHKOV365 Ltd | Transport & logistics | 2015 |
| Double K Ltd | Transport & logistics | 2019 |
| Doublesure Home Improvements Northampton Ltd. | Construction | 2005 |
| Dovetail 3D CAD Solutions Limited | Extraterritorial | 2009 |
| DP Engineering Services (Northants) Limited | Professional & scientific | 2024 |
| DPH GAS Ltd | Construction | 2025 |
| DPS Northampton Ltd | Real estate | 2015 |
| DPS Northants Ltd | Real estate | 2019 |
| DPZ Property Ltd | Real estate | 2023 |
| DR Accountants & Business Advisors Limited | Professional & scientific | 2025 |
| DR Anya Kaushik Limited | Health & social care | 2025 |
| DR. Shaan Aesthetics Ltd | Health & social care | 2019 |
| Drage Roofing Ltd | Construction | 2024 |
| Dragon Information Systems Limited | Information & communication | 2010 |
| Dragons-Fly Ltd | Professional & scientific | 2025 |
| Dragtech Technology Ltd | Information & communication | 2025 |
| Dragut Transport Limited | Construction | 2019 |
| Dramneth Private Ltd | Health & social care | 2023 |
| Draping Bliss Limited | Administrative & support | 2013 |
| Drawde Swerdna Global Inc Ltd | Professional & scientific | 2020 |
| Dream Homes Property Limited | Real estate | 2023 |
| Drill Hall Ltd | Real estate | 2020 |
| Drinceanu Ltd | Transport & logistics | 2020 |
| Drkdsh Group Ltd | Hospitality | 2025 |
| DRL Corporation Limited | Information & communication | 2018 |
| Dropp Network Limited | Administrative & support | 2025 |
| Druce Security Ltd | Administrative & support | 2015 |
| Drumgallagh Homes Limited | Real estate | 2008 |
| DS Demolition & Civil Engineering Ltd | Construction | 2021 |
| DS Drivers Limited | Transport & logistics | 2015 |
| Dsdn Consultancy Ltd | Professional & scientific | 2017 |
| DST Contracting Ltd | Construction | 2023 |
| DT Development Services Limited | Construction | 2015 |
| Dufeu Property Investments Limited | Real estate | 2019 |
| Dulce Hospitality Ltd | Hospitality | 2026 |
| Dulley's Baths Limited | Wholesale & retail | 1999 |
| Dunamis Healthcare Limited | Health & social care | 2018 |
| Dunamis Social Care Limited | Health & social care | 2016 |
| Duncan Brown CAD Services Ltd | Professional & scientific | 2009 |
| Dunnmedia Limited | Information & communication | 2013 |
| Dunore Connections Limited | Construction | 2020 |
| Dunore Developments Limited | Construction | 2023 |
| Dunore Energy Solutions Limited | Construction | 2024 |
| Dunore Group Limited | Construction | 2024 |
| Dushi Hand Car Wash Ltd | Other services | 2017 |
| Duta Logistics Ltd | Transport & logistics | 2025 |
| Dutch Courage Lingerie Ltd | Wholesale & retail | 2018 |
| Dutton Brothers Construction Limited | Construction | 2023 |
| Duwa Ltd | Other services | 2017 |
| DW Roofing Services Ltd | Construction | 2020 |
| DW Telecoms Ltd | Construction | 2024 |
| DWW Construction Ltd | Construction | 2026 |
| Dxpress Limited | Construction | 2021 |
| Dybdale Financial Planning Ltd | Professional & scientific | 2021 |
| Dylkor Limited | Transport & logistics | 2016 |
| Dynamic Infinity Limited | Transport & logistics | 2024 |
| E & R Smile Ltd | Health & social care | 2018 |
| E G Chitiyo Limited | Health & social care | 2012 |
| E J Yuninui & Co Ltd | Health & social care | 2023 |
| E M I Homes Ltd | Transport & logistics | 2023 |
| E O Coatings Ltd | Manufacturing | 2019 |
| E&A Civil Engineering Ltd | Construction | 2024 |
| E&R Consultants Ltd | Professional & scientific | 2016 |
| E&T Groundwork Ltd | Construction | 2022 |
| E.A. Chatfield SAW & Cutter Services Limited | Manufacturing | 1997 |
| E.D. Estates Limited | Agriculture & fishing | 1971 |
| E.G. Shareco Limited | Administrative & support | 2017 |
| E.M Equipment Ltd | Wholesale & retail | 2015 |
| E46 Parts Ltd | Wholesale & retail | 2025 |
| EAG Construction Limited | Construction | 2022 |
| Eagle Civils Limited | Construction | 2025 |
| Earl & Bakshi Estates Limited | Real estate | 2020 |
| Earl Electrical Ltd | Construction | 2014 |
| Earls Holdings Ltd | Financial services | 2019 |
| Earls Holdings Two Limited | Financial services | 2019 |
| EAS Logistics Ltd | Transport & logistics | 2019 |
| East Field Developments Ltd | Administrative & support | 2018 |
| East Midlands Tyre Services Ltd | Wholesale & retail | 2007 |
| Easy Ace Ltd | Hospitality | 2020 |
| Easy Screedy Ltd | Construction | 2025 |
| Easybreezyacservices Limited | Wholesale & retail | 2024 |
| Easymerchant Limited | Wholesale & retail | 2018 |
| Eazy Foods Limited | Wholesale & retail | 2025 |
| EB Market Pro Limited | Wholesale & retail | 2025 |
| Ebsa Bar Company Limited | Hospitality | 2008 |
| Eclipse Emporium Ltd | Wholesale & retail | 2024 |
| Eclipse Pubs Limited | Hospitality | 2026 |
| Ecmaxenda Ltd | Transport & logistics | 2023 |
| Eco Fusion Ltd | Wholesale & retail | 2026 |
| Eco Solutions Worldwide Ltd | Information & communication | 2010 |
| Ecorev Limited | Wholesale & retail | 2025 |
| Edable Ltd | Information & communication | 2010 |
| Edac (Europe) Limited | Wholesale & retail | 1997 |
| Edgar Mutemererwa Limited | Professional & scientific | 2015 |