| Ensure Cleaning Services Ltd | Administrative & support | 2023 |
| Enterprise Database Applications Ltd | Administrative & support | 2007 |
| Enterprise Performance Coaching Limited | Information & communication | 2018 |
| Enterprise Solutions Management Limited | Administrative & support | 2016 |
| Enthuse Coaching and Training Ltd | Professional & scientific | 2018 |
| Entity Networks Ltd | Information & communication | 2019 |
| Entosnack Ltd | Agriculture & fishing | 2024 |
| Entoto Limited | Information & communication | 2023 |
| Entrance Technology Services Limited | Construction | 2004 |
| Entryedit Limited | Wholesale & retail | 2022 |
| Enturi Ltd | Professional & scientific | 2022 |
| Enviro Geeks Consulting Ltd | Professional & scientific | 2004 |
| Environmental Enzymes Limited | Wholesale & retail | 2024 |
| Environmental Property Consultants Ltd | Professional & scientific | 2026 |
| Environmental Quality and Safety Ltd | Professional & scientific | 1994 |
| Enviropet Ltd | Professional & scientific | 2021 |
| Envirotrafix (UK) Ltd | Construction | 2017 |
| Envisage Projects Limited | Administrative & support | 2013 |
| Envisioning Consultancy Ltd | Professional & scientific | 2012 |
| Envo EHS Consulting Ltd | Professional & scientific | 2019 |
| Envobi Ltd | Information & communication | 2011 |
| Envy Advisory Limited | Information & communication | 2017 |
| Envy Analytics Limited | Information & communication | 2024 |
| EOS Solutions UK PLC | Professional & scientific | 1972 |
| EOS Wind Limited | Other services | 2019 |
| Eotgja Limited | Administrative & support | 2024 |
| EP (Industrial & Commercial Painting) Ltd | Construction | 2014 |
| EP Computers Limited | Administrative & support | 2014 |
| EP Engineering Solutions Ltd | Other services | 2019 |
| EP Properties & Estates Ltd | Real estate | 2024 |
| EPC Brickwork Ltd | Construction | 2024 |
| EPC Chief Ltd | Households | 2023 |
| Epeius Studios Limited | Information & communication | 2023 |
| Ephemeral Logic, Ltd | Information & communication | 2013 |
| Ephy Ltd | Real estate | 2021 |
| Epiamed Ltd | Professional & scientific | 2019 |
| Epic Ice Consultants Ltd | Arts & recreation | 2024 |
| Epic PC & Network Services Ltd. | Information & communication | 2015 |
| Epimetheus Limited | Professional & scientific | 2012 |
| EPJ Logistics Limited | Professional & scientific | 2017 |
| Eplust Consultancy Limited | Information & communication | 2018 |
| EPM Engineering Services Limited | Professional & scientific | 2017 |
| EPN Consultants Ltd | Professional & scientific | 2023 |
| Eppseptional Cleaning Services Ltd | Administrative & support | 2022 |
| Eproviders Ltd | Information & communication | 2002 |
| Epsilon RA Limited | Other services | 2021 |
| EQ Training & Consultancy Ltd | Education | 2014 |
| Equasys IT Solutions Ltd | Other services | 2014 |
| Equasys Ltd | Information & communication | 2023 |
| Equinox Limited | Administrative & support | 2007 |
| Equinox Properties MCR Ltd | Real estate | 2014 |
| Equinox Retail Ltd | Wholesale & retail | 2023 |
| Equip AID Ltd | Manufacturing | 2024 |
| Equissentials Dressage Limited | Wholesale & retail | 2020 |
| Equitec Ltd | Information & communication | 2018 |
| Equitrove Limited | Real estate | 2024 |
| Equity Advice Bureau Limited | Financial services | 2019 |
| Equity Release Group Ltd | Financial services | 2022 |
| Equity Release NW Limited | Financial services | 2024 |
| Equity Release Supermarket Ltd | Financial services | 2008 |
| Eqws Photography Ltd | Professional & scientific | 2010 |
| ER Refrigeration Ltd | Construction | 2023 |
| Ercc Holdings Limited | Financial services | 2022 |
| Ercc Limited | Real estate | 2021 |
| ERD Engineering Solutions Limited | Wholesale & retail | 2014 |
| Erfani Medical Limited | Health & social care | 2014 |
| Ergo Coffee Shop Limited | Hospitality | 2024 |
| Erickson Consulting Limited | Administrative & support | 2026 |
| Erikm Ltd | Construction | 2022 |
| Erjomex Limited | Health & social care | 2025 |
| ERM Projects Limited | Administrative & support | 2015 |
| Ermo Consultancy Limited | Professional & scientific | 2021 |
| Ersada Limited | Professional & scientific | 2023 |
| Ertelnnovation Limited | Professional & scientific | 2016 |
| ES & EF Design & Consultancy Ltd | Construction | 2014 |
| ESC Solutions Limited | Administrative & support | 2013 |
| Esdet Solutions Limited | Administrative & support | 2022 |
| Esemena Property Limited | Real estate | 2025 |
| ESF Support Ltd | Health & social care | 2015 |
| ESF Talent Solutions Limited | Administrative & support | 2016 |
| ESH AI Healthcare Limited | Information & communication | 2026 |
| Eskens Tinting Solutions UK Limited | Manufacturing | 2004 |
| Esky Ltd | Administrative & support | 2008 |
| Eslo Ltd | Professional & scientific | 2021 |
| Esolve Limited | Professional & scientific | 2018 |
| Esox Technologies Ltd | Manufacturing | 2025 |
| Esposito Consultancy Ltd | Information & communication | 2019 |
| ESR Technology Limited | Professional & scientific | 2005 |
| Esselle Services Limited | Professional & scientific | 2018 |
| Essemess Limited | Professional & scientific | 2017 |
| Essens UK Consultancy Ltd | Professional & scientific | 2024 |
| Essens UK Ltd | Other services | 2018 |
| Essential Deliveries Limited | Transport & logistics | 2005 |
| Essential Fire Solutions Limited | Other services | 2019 |
| Essential Lawn Care Ltd | Other services | 2010 |
| Essential Mediation Solutions Limited | Professional & scientific | 2019 |
| Essex Dental & Aesthetics Limited | Health & social care | 2021 |
| Essorant Aerospace Ltd | Extraterritorial | 2016 |
| Estates & Ember Limited | Real estate | 2024 |
| Estatetalk Ltd | Information & communication | 2025 |