| Spencer Schwartz Consulting Limited | Other services | 2019 |
| Spenjco Ltd | Wholesale & retail | 2025 |
| Sperrin Automation and Controls Limited | Administrative & support | 2015 |
| SPH Consulting Limited | Administrative & support | 2016 |
| Sphere Consumer Products Limited | Wholesale & retail | 2004 |
| SPI Design Development Limited | Professional & scientific | 2018 |
| Spic and Span Cleaning Services Limited | Other services | 2006 |
| Spice Junction Warrington Ltd | Hospitality | 2025 |
| Spice of India Restaurant Ltd | Hospitality | 2024 |
| Spice Warrington Ltd | Hospitality | 2024 |
| Spier Consulting Limited | Administrative & support | 2004 |
| Spier Group Limited | Other services | 2019 |
| Spike Mears Ltd | Professional & scientific | 2023 |
| Spiky Ball Design Limited | Administrative & support | 2013 |
| Spin RG Ltd | Administrative & support | 2023 |
| Spinnin Limited | Administrative & support | 2024 |
| Spinning Ducks Limited | Households | 2019 |
| Spire Engineering and Services Ltd | Administrative & support | 2026 |
| Spire HR Franchise Limited | Professional & scientific | 2025 |
| Spire HR Solutions Limited | Administrative & support | 2010 |
| Spirel Limited | Information & communication | 2016 |
| Spires Holdings Ltd | Financial services | 2016 |
| Spires Leisure Ltd | Hospitality | 2016 |
| Spitfire Holdings Ltd | Real estate | 2026 |
| SPK Europe Ltd | Wholesale & retail | 2018 |
| SPL Technologies Limited | Information & communication | 2023 |
| Splash Wall Design Ltd | Construction | 2022 |
| Splendid Stationery Limited | Manufacturing | 2025 |
| Splice Engineering Limited | Administrative & support | 2012 |
| SPM & C Consultancy Limited | Administrative & support | 2023 |
| SPM Composites Limited | Administrative & support | 2025 |
| SPM Fire Limited | Professional & scientific | 2025 |
| Spmu Kirsty Lord Ltd | Other services | 2021 |
| SPN Assembly Limited | Manufacturing | 2024 |
| Spongie Hand Car Wash Ltd | Administrative & support | 2025 |
| Spooky World Ltd | Professional & scientific | 2018 |
| Spoolbeck Limited. | | 1981 |
| Sport-E Limited | Professional & scientific | 2008 |
| Sports Channel Network Limited | Information & communication | 2017 |
| Sports Couture Ltd | Wholesale & retail | 2025 |
| Sports Enviro Limited | Professional & scientific | 2015 |
| Sports Glamour Ltd. | Arts & recreation | 2011 |
| Sports Medicine North West Limited | Health & social care | 2018 |
| Sports Tours International Limited | Administrative & support | 1987 |
| Sportsfactory Consulting Limited | Arts & recreation | 1999 |
| Spot on Warrington Limited | Wholesale & retail | 2026 |
| Spotless (North West) Limited | Other services | 2002 |
| Spotlight Pathology Ltd | Information & communication | 2020 |
| Spotmate Limited | Other services | 2022 |
| Spots.Hq Ltd | Wholesale & retail | 2026 |
| Spotswood Facilities Management Limited | Professional & scientific | 2019 |
| SPP Engineering Services Ltd | Administrative & support | 2025 |
| SPR Property Group Ltd | Real estate | 2026 |
| Spra Health Enterprise Ltd | Administrative & support | 2025 |
| Spraymoon Technologies Limited | Information & communication | 2012 |
| Spraywise Ltd | Wholesale & retail | 2022 |
| Spreadit Sourcing Ltd | Wholesale & retail | 2024 |
| Spring Croft Farm Ltd | Education | 2026 |
| Spring Digital Network CIC | Education | 2022 |
| Spring Network Limited | Information & communication | 2016 |
| Springate Building Company Limited | Construction | 2022 |
| Springboard Marketing & Communications Limited | Information & communication | 2013 |
| Springfield Cheshire Free Range Eggs Limited | Agriculture & fishing | 2009 |
| Springfield Estates Limited | Real estate | 2012 |
| Springwell Parma Limited | Administrative & support | 2024 |
| Springwell Pharma Limited | Administrative & support | 2024 |
| Springwire Limited | Financial services | 2018 |
| Springwood Estates Ltd | Real estate | 2017 |
| Springwood Networks Ltd | Information & communication | 2021 |
| Springwood Nursery Limited | Education | 2007 |
| Sprintpro Star Ltd | Wholesale & retail | 2025 |
| Spruce Building Ltd | Construction | 2024 |
| Spruce Cleaning Solutions Ltd | Administrative & support | 2019 |
| SPS Newsagents Ltd | Wholesale & retail | 2025 |
| Spsf Ltd | Transport & logistics | 2026 |
| Spud Sisters Limited | Hospitality | 2026 |
| Spud Yeds Ltd | Hospitality | 2024 |
| Spurtle Software Limited | Information & communication | 2014 |
| SPVY0001 Limited | Administrative & support | 2016 |
| SPVY00010 Limited | Administrative & support | 2018 |
| SPVY00012 Ltd | Administrative & support | 2019 |
| SPVY00013 Ltd | Administrative & support | 2019 |
| SPVY00019 Ltd | Administrative & support | 2019 |
| SPVY00020 Ltd | Administrative & support | 2019 |
| SPVY00022 Ltd | Administrative & support | 2020 |
| SPVY00024 Ltd | Administrative & support | 2020 |
| SPVY00025 Ltd | Administrative & support | 2020 |
| SPVY00026 Ltd | Administrative & support | 2021 |
| SPVY00027 Ltd | Administrative & support | 2021 |
| SPVY00028 Ltd | Administrative & support | 2021 |
| SPVY00029 Ltd | Administrative & support | 2021 |
| SPVY00031 Ltd | Administrative & support | 2021 |
| SPVY0005 Limited | Administrative & support | 2016 |
| SPVY0006 Limited | Administrative & support | 2018 |
| SPVY0007 Limited | Administrative & support | 2018 |
| SPVY0009 Ltd | Administrative & support | 2018 |
| SPW Design Engineering Limited | Professional & scientific | 2018 |
| Sqrl Engineering Ltd | Administrative & support | 2023 |
| Square Bar Limited | Hospitality | 2026 |
| Square Brick Construction Limited | Construction | 2023 |