| Sonicphaze Logistics Ltd | Transport & logistics | 2015 |
| SONIO13 Services Limited | Transport & logistics | 2022 |
| Sonomatic Limited | Professional & scientific | 2003 |
| Sonova Service Center UK Limited | Manufacturing | 2014 |
| Sonova UK Limited | Wholesale & retail | 1997 |
| Sons of the North Limited | Hospitality | 2017 |
| Sonzaikan Limited | Health & social care | 2020 |
| Sopays Washed Limited | Other services | 2025 |
| Sophia BGN Ltd | Transport & logistics | 2024 |
| Soran Renovation Limited | Construction | 2018 |
| Sorelle Limited | Wholesale & retail | 2015 |
| Sorg Medlaw Ltd | Health & social care | 2022 |
| Sorimas Ltd | Real estate | 2025 |
| Sorton Property Limited | Real estate | 2021 |
| Sorton Solutions Limited | Professional & scientific | 2009 |
| Soso Property Lettings and Leasing Limited | Real estate | 2024 |
| Soteria (UK) Limited | Administrative & support | 2007 |
| Soul Giraffe Studios Ltd | Wholesale & retail | 2025 |
| Soulmateen Ltd | Wholesale & retail | 2025 |
| Sound Resonance Ltd | Education | 2014 |
| Sound Sessions Ltd | Education | 2025 |
| Soundglobal Trading Limited | Manufacturing | 1993 |
| Sourced Construction Limited | Households | 2021 |
| Sourced Financial Services Limited | Financial services | 2023 |
| Sourced Formations Limited | Information & communication | 2024 |
| Sourced Group Limited | Administrative & support | 2019 |
| Sourced Living Limited | Other services | 2023 |
| Sourced Management Services Limited | Financial services | 2021 |
| Sourced Network Limited | Administrative & support | 2022 |
| Sourced Portfolio Limited | Financial services | 2023 |
| Sourcey Ltd | Real estate | 2023 |
| Souter Design Ltd | Administrative & support | 2013 |
| South Downs Holdings Ltd | Financial services | 2023 |
| South Manchester Bathrooms Limited | Construction | 2015 |
| South Manchester Properties Ltd | Real estate | 2019 |
| South Sea Surveying Limited | Professional & scientific | 2025 |
| South Suntreso Limited | Information & communication | 2024 |
| South Wales Process & Control Limited | Administrative & support | 2012 |
| South Warrington Sports Club (Management) Limited | Arts & recreation | 2019 |
| South West Design Solutions Limited | Information & communication | 2016 |
| South Windows Ltd | Construction | 2014 |
| Southern Asia Developments Limited | Professional & scientific | 1995 |
| Southern Roberts Properties Ltd | Real estate | 2023 |
| Southgrove (Lancashire) Limited | Other services | 2024 |
| Southgrove (North West) Limited | Wholesale & retail | 2013 |
| Southport Music Community C.I.C. | Arts & recreation | 2010 |
| Southtrent Limited | Administrative & support | 2015 |
| Southwell Wellness & Spa Ltd | Other services | 2025 |
| Southwest Software Development Ltd | Information & communication | 2019 |
| Southwest Surgical Associates Ltd. | Health & social care | 2014 |
| Sovereign Engineering Ltd | Professional & scientific | 2022 |
| Sovereign-World Limited | Information & communication | 1986 |
| SOW Success Ltd | Administrative & support | 2025 |
| Soysa Consulting Limited | Administrative & support | 2014 |
| SP Civils Ltd | Construction | 2019 |
| SP Constuction Consultancy Limited | Administrative & support | 2026 |
| SP Dunn Engineering Limited | Administrative & support | 2013 |
| SP Newland Enterprise Limited | Administrative & support | 2017 |
| SP Thermal Solutions Ltd | Education | 2018 |
| Sp@Yumi Limited | Other services | 2025 |
| Spa Beautiful UK Ltd | Other services | 2025 |
| Space Building Projects (Cheshire) Limited | Construction | 2020 |
| Space Building Projects (NW) Limited | Construction | 2017 |
| Space First (Manchester) Limited | Administrative & support | 2015 |
| Space First (North West) Limited | Administrative & support | 2015 |
| Space First (South East) Limited | Administrative & support | 2015 |
| Space Homes Ltd | Real estate | 2022 |
| Space Investment (NW) Limited | Real estate | 2018 |
| Space Studio Home Limited | Wholesale & retail | 2024 |
| Spaceage Engineers Limited | Administrative & support | 2010 |
| Spark in the Dark Limited | Information & communication | 2014 |
| Sparkle Capital Limited | Financial services | 2014 |
| Sparkles Events Limited | Wholesale & retail | 2019 |
| Sparklife Technology Limited | Information & communication | 2015 |
| Sparks Pharma Limited | Health & social care | 2023 |
| Spartan Training Services Ltd | Administrative & support | 2026 |
| Spdd Ltd | Transport & logistics | 2018 |
| Speakman Developments Limited | Real estate | 2006 |
| Speakman Property Solutions Limited | Construction | 2024 |
| Spearhall Limited | Wholesale & retail | 1991 |
| Special Handyman Ltd | Construction | 2024 |
| Specialised Access Solutions Ltd | Construction | 2011 |
| Specialised WMS Solutions Ltd | Information & communication | 2017 |
| Specialist AI Limited | Information & communication | 2026 |
| Specialist Cover Limited | Hospitality | 2001 |
| Specialist Engineers Limited | Administrative & support | 2012 |
| Specialist Lighting Services Limited | Professional & scientific | 1999 |
| Speciality Gases UK Ltd | Extraterritorial | 2014 |
| Specific Management | Administrative & support | 2003 |
| Specola Limited | Wholesale & retail | 2013 |
| Spectraa Ltd | Wholesale & retail | 2025 |
| Spectre Electrical Supplies Ltd | Manufacturing | 2025 |
| Spectrum North West Ltd | Health & social care | 2024 |
| SPECTRUMRESERVE4 Ltd | Energy | 2017 |
| SPECTRUMRESERVE5 Ltd | Energy | 2017 |
| Speech & Language Works Limited | Health & social care | 2006 |
| Speedkarting Limited | Real estate | 1988 |
| Speedy Mobile Mechanics Ltd | Wholesale & retail | 2021 |
| Spektrum Apparel Limited | Wholesale & retail | 2015 |
| Spektrum Electrical Ltd | Construction | 2007 |