| Shaun Smith Enterprises Limited | Administrative & support | 2014 |
| Shaw & Roughley Limited | Other services | 2005 |
| Shaw Building and Joinery Limited | Construction | 2019 |
| Shaw Design Solutions Ltd | Other services | 2019 |
| Shaw Engineering Software and Robotics Ltd | Information & communication | 2002 |
| Shaw Sele Limited | Administrative & support | 2016 |
| Shawarma Warrington Ltd | Hospitality | 2025 |
| Shawbrook Holdings Ltd | Financial services | 2015 |
| Shawfield Line Marking Specialists Limited | Construction | 1999 |
| Shayes Consulting Limited | Professional & scientific | 2026 |
| SHB Testing Services Limited | Information & communication | 2015 |
| She's the Boss Ltd. | Manufacturing | 2013 |
| Shearwater Medical Limited | Health & social care | 2024 |
| Shee Beauty Ltd | Wholesale & retail | 2015 |
| Shee UK Ltd | Wholesale & retail | 2022 |
| Sheehy Property Developments Ltd | Real estate | 2025 |
| Sheethal Estates Ltd | Real estate | 2024 |
| Sheldon Consultancy (Chester) Limited | Professional & scientific | 1997 |
| Sheldon Consultancy Limited | Professional & scientific | 1995 |
| Shell AD Training Services Ltd | Education | 2020 |
| Shelley K Fashion Limited | Wholesale & retail | 2001 |
| Shelljos Ltd | Administrative & support | 2017 |
| Shelly Beli Limited | Transport & logistics | 2025 |
| Shepherd Medical Communications Ltd | Professional & scientific | 2023 |
| Shepherd Taylor Superconducting Limited | Professional & scientific | 2025 |
| Sheppard Group Limited | Extraterritorial | 1978 |
| Sheppard Property Investments Ltd | Real estate | 2025 |
| Sherbet Lemons Limited | Information & communication | 2000 |
| Shergill IT Solutions Ltd | Information & communication | 2018 |
| Sheridan City Investments Limited | Real estate | 2013 |
| Sheridan Equation Limited | Professional & scientific | 2013 |
| Sherlock Family Homes Ltd | Households | 2020 |
| Sherlock Homes (Lettings) Limited | Real estate | 2016 |
| Sherwin's Services Ltd | Administrative & support | 2026 |
| Sherwood (H2O) Management Limited | Extraterritorial | 2006 |
| Sherwood (KD) Management Limited | Extraterritorial | 2005 |
| Sherxaske Limited | Hospitality | 2023 |
| Shield Intelligence Ltd | Information & communication | 2021 |
| Shield Property Care Ltd | Construction | 2025 |
| Shield Realty Limited | Real estate | 2025 |
| Shields & Sons Ltd | Construction | 2016 |
| Shifa Holistic Therapies Ltd | Wholesale & retail | 2023 |
| Shift Health and Fitness Limited | Administrative & support | 2017 |
| Shimara Limited | Professional & scientific | 2016 |
| Shimeril Limited | Information & communication | 2017 |
| Shin YIN Tong Chinese Medicine Clinic Ltd | Health & social care | 2024 |
| Shine Property Management Ltd | Real estate | 2025 |
| Shining Corner CIC | Other services | 2024 |
| Shining Rainbow Limited | Wholesale & retail | 2021 |
| Shiny Consultancy Limited | Professional & scientific | 2024 |
| Shiny Stones Design Limited | Wholesale & retail | 2025 |
| Shipd Ventures Ltd | Information & communication | 2025 |
| Shipsmart Couriers Ltd | Transport & logistics | 2025 |
| Shishko Ltd | Administrative & support | 2017 |
| Shiva Ecom Ltd | Wholesale & retail | 2026 |
| Shivanssh Engineering Ltd | Professional & scientific | 2025 |
| Shivery Ltd | Wholesale & retail | 2024 |
| SHM Enterprise Limited | Administrative & support | 2014 |
| Shodhana Limited | Professional & scientific | 2012 |
| Shoebill Data Science Solutions Limited | Administrative & support | 2024 |
| Shoehorse Ltd | Hospitality | 2025 |
| Sholway Limited | Hospitality | 1973 |
| Shoney Limited | Real estate | 2026 |
| Shookoo Technology Services Limited | Information & communication | 2017 |
| Shoreline Business Solutions Ltd | Administrative & support | 2017 |
| Shorties Ltd | Administrative & support | 2015 |
| Shortspeed Limited | Real estate | 1998 |
| Showboxx Ltd | Arts & recreation | 2024 |
| Showman Events Ltd | Arts & recreation | 2019 |
| SHP Design Consultants Ltd | Financial services | 2019 |
| SHR Developments (NW) Ltd | Real estate | 2021 |
| Shrajm Unlimited | Financial services | 2025 |
| Shreneel Ltd | Health & social care | 2021 |
| Shri Krishna Limited | Information & communication | 2012 |
| Shrihan Limited | Professional & scientific | 2019 |
| SHS Homes Limited | Construction | 2015 |
| Shukla Consulting Limited | Information & communication | 2013 |
| Shumba Consulting Limited | Information & communication | 2018 |
| SI Resource Consultants Ltd | Information & communication | 2019 |
| Siam Smile Ltd | Hospitality | 2025 |
| Siassipour Consulting Ltd | Administrative & support | 2026 |
| Sieden Limited | Wholesale & retail | 2013 |
| Sienna Consultancy Ltd | Professional & scientific | 2021 |
| Sigaram Tamil School Limited | Education | 2023 |
| Sigi Holdings Limited | Financial services | 2024 |
| Sigma (NW) Limited | Water & waste | 2022 |
| Sigma Computing UK Limited | Information & communication | 2023 |
| Sigma Energy Ltd | Professional & scientific | 2022 |
| Sigma Financial Solutions Ltd | Professional & scientific | 2025 |
| Sigma Management International Ltd | Professional & scientific | 2008 |
| Sigma Praxis Limited | Professional & scientific | 2017 |
| Sigma-Ad Engineering Limited | Professional & scientific | 2019 |
| Signal Woods Limited | Administrative & support | 2025 |
| Signature (Devonshire) Ltd | Construction | 2017 |
| Signature Childcare Limited | Professional & scientific | 2020 |
| Signature Glazing Concepts Ltd. | Construction | 2025 |
| Signature Homes and Lettings Agent Limited | Real estate | 2025 |
| Signature Technical Limited | Administrative & support | 2025 |
| Signclad Limited | Professional & scientific | 2013 |
| Signia Search & Selection Group Ltd | Administrative & support | 2015 |