| Send Tuition Limited | Education | 2023 |
| Sendeducate CIC | Professional & scientific | 2023 |
| Sengupta Consulting Limited | Health & social care | 2026 |
| Senna Technology Solutions Limited | Administrative & support | 2014 |
| Sense 8 (UK) Ltd | Information & communication | 2006 |
| Sense Films Ltd | Information & communication | 2021 |
| SENSE4INSIGHT & Control Limited | Manufacturing | 2025 |
| Senshi Academy Limited | Education | 2015 |
| Sensible Ecological Survey Solutions Limited | Professional & scientific | 2012 |
| Sentinel Consultancy Solutions Ltd | Professional & scientific | 2019 |
| Sentinel Performance Solutions Group Limited | Manufacturing | 2010 |
| Sentinel Performance Solutions Limited | Manufacturing | 2005 |
| Sentinel Services Group Limited | Professional & scientific | 2018 |
| Sentinel WC UK Ltd | Manufacturing | 2026 |
| Sentire UK Ltd | Information & communication | 2023 |
| Sentis Managed Solutions Ltd | Information & communication | 2014 |
| Sentra Developments Limited | Administrative & support | 2014 |
| Sentry Security Limited | Administrative & support | 2001 |
| Seob Management Limited | Other services | 2018 |
| Sephura Digital Consultancy Limited | Information & communication | 2000 |
| Septentrion Business Limited | Information & communication | 2018 |
| Sequential Investments Limited | Real estate | 2018 |
| Sequential-E Limited | Wholesale & retail | 2014 |
| SER77 Ltd | Hospitality | 2026 |
| Sera NW Limited | Hospitality | 2025 |
| Serebus Limited | Information & communication | 2018 |
| Serendipity Homes Limited | Construction | 2024 |
| Serene Zenith Ltd | Real estate | 2024 |
| Serketech Limited | Administrative & support | 2015 |
| Serv Plant Hire Limited | Administrative & support | 2016 |
| Servace Consulting Ltd | Information & communication | 2024 |
| Servatius Consulting Limited | Professional & scientific | 2009 |
| Service Excellence Ltd | Information & communication | 2012 |
| Serviceright Associates Ltd | Administrative & support | 2013 |
| Services by ACW Ltd | Administrative & support | 2026 |
| Services Link Ltd | Wholesale & retail | 2024 |
| SET6 Ltd | Manufacturing | 2022 |
| Setab Packaging Consultancy Ltd | Professional & scientific | 2025 |
| Seth Mitchell Ltd | Professional & scientific | 2026 |
| Seven Eleven Group Limited | Extraterritorial | 2019 |
| Seven Hills Radiology Limited | Financial services | 2018 |
| Seven Lettings & Property Limited | Real estate | 2024 |
| Seven One Automation Limited | Information & communication | 2009 |
| Seven Stars Broadcast Limited | Information & communication | 2015 |
| Seven Summit Holdings Ltd | Financial services | 2026 |
| Sevenoaks Industries Ltd | Construction | 2024 |
| Seventy Thirty Golf Limited | Arts & recreation | 2026 |
| Seville Engineering Surveyors Limited | Professional & scientific | 2010 |
| SEW N SO Ltd | Other services | 2025 |
| Sewell Auto Electric & Battery Centre Limited | Wholesale & retail | 2013 |
| SF Consulting Limited | Information & communication | 2023 |
| SF Enterprise Limited | Financial services | 2006 |
| Sfane Limited | Administrative & support | 2016 |
| Sfaz Aviation Ltd | Administrative & support | 2025 |
| SFD Consulting Services Limited | Information & communication | 2016 |
| SG Companies Limited | Professional & scientific | 2025 |
| SG Motors Warrington Limited | Wholesale & retail | 2022 |
| SG Properties (North West) Limited | Households | 2026 |
| SG Sports Equipment Limited | Wholesale & retail | 2014 |
| SGH Developments Ltd | Construction | 2024 |
| SGJ Consulting Limited | Professional & scientific | 2018 |
| SGJ Engineering Limited | Administrative & support | 2013 |
| Sgkw Limited | Administrative & support | 2014 |
| SGM Consultants Limited | Administrative & support | 2007 |
| SGM Projects Ltd | Professional & scientific | 1994 |
| SGM Property Ltd | Construction | 2017 |
| SGP Property Group Ltd | Real estate | 2024 |
| Sgrk Limited | Real estate | 2024 |
| SGS Consulting Ltd | Transport & logistics | 2025 |
| SGT Consulting SW Ltd | Administrative & support | 2023 |
| SGV Engineering Services Limited | Construction | 2017 |
| SH Building Services Limited | Administrative & support | 2007 |
| SH Contractor Ltd | Transport & logistics | 2024 |
| SH Corporate Lettings Ltd | Real estate | 2023 |
| SH Property & Rentals Ltd | Real estate | 2022 |
| SH Serviced Accommodation Ltd | Hospitality | 2022 |
| Shades of Green (North West) Limited | Agriculture & fishing | 2010 |
| Shadow Engineering Limited | Administrative & support | 2014 |
| Shah Ecomm Limited | Wholesale & retail | 2023 |
| Shahaan Traders Ltd | Professional & scientific | 2025 |
| Shahen Hawler Ltd | Wholesale & retail | 2025 |
| Shaikh Data Services Ltd | Professional & scientific | 2020 |
| Shaiva Property Ltd | Real estate | 2025 |
| Shake Padiham Limited | Hospitality | 2021 |
| Shakti Business Ltd | Professional & scientific | 2019 |
| Shalom Delicate Care Limited | Health & social care | 2021 |
| Sham & Sons Incorporated Ltd | Information & communication | 2010 |
| Shanakee Properties Ltd. | Real estate | 2022 |
| Shane Atkinson Technical Author Limited | Administrative & support | 2015 |
| Shannon & Bayes Ltd | Administrative & support | 2018 |
| Sharella Services Limited | Administrative & support | 2016 |
| Sharkey PM Consulting Limited | Administrative & support | 2023 |
| Sharman Multicom Limited | Wholesale & retail | 1999 |
| Sharp Commissioning Management Ltd | Administrative & support | 2024 |
| Sharp Design Consultancy Ltd | Administrative & support | 2007 |
| Sharp Process Consultants Ltd | Administrative & support | 2013 |
| Sharp Supplies Limited | Wholesale & retail | 2025 |
| Sharpe Tooling Limited | Manufacturing | 1988 |
| Sharples Portugal Property Limited | Professional & scientific | 2015 |
| Shasti Engineering Limited | Professional & scientific | 2018 |