| Saco Investments Limited | Professional & scientific | 2011 |
| Saddington Consultants Ltd | Financial services | 2020 |
| Sadhvika Software Ltd | Information & communication | 2018 |
| SAF Financial Consultancy (UK) Ltd | Financial services | 2018 |
| Safa Armani Solutions Ltd | Information & communication | 2017 |
| Safe and Snappy Ltd | Wholesale & retail | 2025 |
| Safe Hands Flooring Ltd | Administrative & support | 2017 |
| Safe Hands Private Day Nursery Limited | Administrative & support | 2001 |
| Safe Haven Crisis Care Ltd | Health & social care | 2025 |
| Safe Spark Contractors Limited | Construction | 2017 |
| Safe.T Priority Limited | Information & communication | 2024 |
| Safedove Limited | Financial services | 2012 |
| SAFEHANDS4IT Limited | Information & communication | 2018 |
| Safehaven Insideout Ltd | Professional & scientific | 2016 |
| Safehawk Limited | Financial services | 2000 |
| SAFEIN5 Ltd | Extraterritorial | 2013 |
| Safesom Ltd | Administrative & support | 2026 |
| Safety & Reliability Engineering Limited | Administrative & support | 2012 |
| Safety by Design Solutions Ltd | Administrative & support | 2026 |
| Safety Netting Solutions Ltd | Construction | 2025 |
| Safetyspecs.Co.Uk Limited | Wholesale & retail | 2012 |
| Saffa Fashion Ltd | Wholesale & retail | 2022 |
| Saffy's Limited | Wholesale & retail | 2003 |
| Safic-Alcan UK Limited | Wholesale & retail | 1957 |
| Safi’S Awad Ltd | Hospitality | 2025 |
| Saftrol Limited | Manufacturing | 2009 |
| Sagacity Insights Limited | Professional & scientific | 2018 |
| Sagadesigns Ltd | Information & communication | 2019 |
| Sage Chameleon Ltd | Information & communication | 2024 |
| Sagger & Sons Engineering Ltd | Administrative & support | 2025 |
| Sagulo Coaching & Mentoring Services Limited | Administrative & support | 2016 |
| Sahi Consulting Limited | Administrative & support | 2024 |
| SAI Krishna IT Services Limited | Information & communication | 2012 |
| SAI Medical Buildings Limited | Real estate | 2011 |
| SAI Puri Investments Limited | Real estate | 2019 |
| SAI Segitech Estates Limited | Real estate | 2019 |
| SAI Shaiva Ltd | Health & social care | 2023 |
| Saika Limited | Hospitality | 2019 |
| Sail Leisure Ltd | Transport & logistics | 2026 |
| Sailr Solutions Ltd | Information & communication | 2013 |
| Saimu Limited | Information & communication | 2017 |
| Saint-Rome Ltd | Administrative & support | 2022 |
| Saisha Property Limited | Real estate | 2022 |
| Sajr Consultancy Limited | Administrative & support | 2009 |
| SAK 1 Limited | Real estate | 2021 |
| Sakan Bistro Ltd | Hospitality | 2023 |
| Salar Pro Marketing Limited | Information & communication | 2019 |
| Saldanha Engineering Limited | Professional & scientific | 2019 |
| Sale and Lettings Real Estate Ltd | Real estate | 2025 |
| Sale Electrical Engineering Limited | Administrative & support | 2015 |
| Sale Fencing & Surfacing Ltd | Manufacturing | 1981 |
| Saleem Akhtar Limited | Health & social care | 2025 |
| Saleema Simmons Consultancy Ltd | Health & social care | 2013 |
| Salgood Limited | Administrative & support | 2019 |
| Salim Malik 2 Ltd | Financial services | 2026 |
| Salima Consulting Limited | Professional & scientific | 2017 |
| Sally Lyons Consulting Limited | Professional & scientific | 2021 |
| Salmanov Limited | Administrative & support | 2014 |
| Salon Pierre Aesthetics Ltd | Other services | 2023 |
| Salon Pierre Limited | Other services | 2008 |
| Salon Professional Solutions Ltd | Other services | 2019 |
| Saloni Jain Limited | Administrative & support | 2025 |
| Salopian Designs Ltd | Professional & scientific | 2023 |
| Salsa Online Limited | Wholesale & retail | 2017 |
| Salsa Revival Ltd | Wholesale & retail | 2025 |
| Salt POT Hospitality Ltd | Hospitality | 2025 |
| Salt POT Staffing Ltd | Administrative & support | 2025 |
| Saltant Ltd | Professional & scientific | 2019 |
| Saltire Surveying Ltd | Administrative & support | 2021 |
| Saltwater Consulting Limited | Information & communication | 2017 |
| Salus Contracting Ltd | Administrative & support | 2026 |
| Salvada Group Ltd | Administrative & support | 2025 |
| Salvia Software Limited | Information & communication | 2021 |
| SAM Barbers Warrington Ltd | Other services | 2021 |
| SAM D Williams Ltd | Wholesale & retail | 2021 |
| SAM Neachell Consulting Limited | Administrative & support | 2026 |
| Samantha Pendry Consulting Ltd | Professional & scientific | 2026 |
| Samantha Shiel Therapies Limited | Professional & scientific | 2026 |
| Samko SL Ltd | Wholesale & retail | 2020 |
| Sammy Louise Ltd | Professional & scientific | 2026 |
| Samphire Holdings Limited | Administrative & support | 2016 |
| Samra Cyber Solutions Ltd | Information & communication | 2024 |
| Samuel Fenwick-Smith Limited | Professional & scientific | 2020 |
| Samuel Muir Consulting Ltd | Information & communication | 2026 |
| Samuel Peter Services Ltd | Professional & scientific | 2019 |
| Samy and Scott Limited | Professional & scientific | 2023 |
| SAN Jose Ventures Limited | Financial services | 2023 |
| SAN Lorenzo Restaurant Warrington Limited | Hospitality | 2017 |
| Sancli Ltd | Wholesale & retail | 2023 |
| Sanclimenti Ltd | Arts & recreation | 2022 |
| Sanctuary Estates Ltd. | Information & communication | 2014 |
| Sanctuary Skin Clinic Ltd | Other services | 2020 |
| Sand Castle Holiday Homes Ltd | Hospitality | 2025 |
| Sandalwood IS Management Limited | Information & communication | 2017 |
| Sandells & Co. Limited | Professional & scientific | 2003 |
| Sanderson Business Services Limited | Administrative & support | 2014 |
| Sanderson Technology Services Ltd | Information & communication | 2021 |
| Sandesoft Limited | Information & communication | 2007 |
| Sandgrown Care Ltd | Health & social care | 2025 |
| Sandher Real Estate Ltd | Real estate | 2020 |