| Searchlight Solutions Ltd | Administrative & support | 2004 |
| Seasonal Gardens Limited | Wholesale & retail | 2012 |
| Second Letter Limited | Professional & scientific | 2023 |
| Secondchaptertw Ltd | Wholesale & retail | 2025 |
| Secr Limited | Construction | 2014 |
| Secretive Limited | Information & communication | 2017 |
| Secrets of Shed Building Ltd | Information & communication | 2008 |
| Section 106 Reclaim Limited | Financial services | 2025 |
| Security and Resilience Technologies Limited | Administrative & support | 2025 |
| Securus Recruitment Ltd | Administrative & support | 2020 |
| SEGAR3D Limited | Administrative & support | 2018 |
| Selbourne Limited | Administrative & support | 2007 |
| Selbu Inc Ltd | Professional & scientific | 2018 |
| Selcot Cleaning Services Limited | Administrative & support | 2008 |
| Selstar Limited | Professional & scientific | 2021 |
| Semonov Ltd | Information & communication | 2014 |
| Sensia UK Ltd. | Manufacturing | 2019 |
| Sentinel Core Services Limited | Administrative & support | 1996 |
| Sentinel Group Holdings Limited | Professional & scientific | 2015 |
| Sentinel Group Limited | Professional & scientific | 2020 |
| Sentinel International Ltd | Administrative & support | 2018 |
| Sentinel Technology Ltd | Administrative & support | 2015 |
| Seon Diagnostics Limited | Information & communication | 2011 |
| Sepiks Ltd | Information & communication | 2015 |
| September Publishing Limited | Information & communication | 2013 |
| Serene Interiors Spaces Limited | Wholesale & retail | 2024 |
| Serenity Therapies (Tunbridge Wells) Ltd | Real estate | 2024 |
| SERIES56 Ltd | Administrative & support | 2020 |
| Serio Technical Solutions Limited | Information & communication | 2024 |
| Serran Estates LLP | | 2024 |
| Servecroft Limited | Households | 1994 |
| Serverminer Limited | Information & communication | 2012 |
| Service Image Limited | Arts & recreation | 2023 |
| SET Property Management Limited | Real estate | 2018 |
| SET Solutions Ltd | Administrative & support | 2016 |
| SET Style Limited | Wholesale & retail | 2022 |
| Seti Holdings Limited | Professional & scientific | 2022 |
| Settle Retail Limited | Wholesale & retail | 2003 |
| Sevenoaks Art Class Ltd | Education | 2021 |
| Sevenoaks Environmental Consultancy Limited | Professional & scientific | 2005 |
| Sevenoaks Interiors Ltd | Extraterritorial | 2014 |
| Sevenoaks Van Sales Limited | Wholesale & retail | 2010 |
| Seventh Wave Supplements Limited | Extraterritorial | 2009 |
| Seventyseven Holdings Limited | Extraterritorial | 2017 |
| Seventyseven Investments Limited | Financial services | 2025 |
| Seventyseven Wealth Management Limited | Administrative & support | 2013 |
| Seyf Ltd | Real estate | 2025 |
| SEZ Consultancy Limited | Information & communication | 2016 |
| SEZ Property Management Services Ltd | Real estate | 2022 |
| SFV Consultants Ltd | Construction | 2007 |
| SG Fitness Ltd | Arts & recreation | 2018 |
| SGS Design Limited | Professional & scientific | 2012 |
| Sgsad Ltd | Professional & scientific | 2022 |
| SGV Compliance Limited | Administrative & support | 2025 |
| Shades of Summer Ltd | Wholesale & retail | 2021 |
| Shagral Ltd | Information & communication | 2024 |
| Shagun Holdings Ltd | Professional & scientific | 2025 |
| Shah-Kamal Limited | Hospitality | 2025 |
| Shakespeare Engineering Global Holdings Limited | Financial services | 2024 |
| Shakespeare Engineering Holdings Limited | Financial services | 2024 |
| Shakespeare Engineering International (Asia) (Holdings) Limited | Financial services | 2024 |
| Shakespeare Engineering International (Holdings) Limited | Financial services | 2024 |
| Shakespeare Engineering Limited | Manufacturing | 2024 |
| Shakespeare Engineering Trading LLP | | 2024 |
| Shakespeare's Rose Theatre Ltd | Arts & recreation | 2018 |
| Shannon Leona Ltd | Professional & scientific | 2019 |
| Shard Systems Ltd | Information & communication | 2020 |
| Shareslot Property Management Limited | Real estate | 1989 |
| Shark Houses Ltd | Real estate | 2022 |
| Sharon Jiggins Consultancy Limited | Professional & scientific | 2023 |
| Sharp Minds Communications Ltd | Professional & scientific | 2015 |
| Sharp Thinking Marketing Ltd | Professional & scientific | 2018 |
| Sharpe Architecture Ltd | Professional & scientific | 2019 |
| Sharsted Court Heritage Management Company Limited | Real estate | 2019 |
| Shasten Homes Limited | Construction | 2026 |
| Shaun Ltd | Real estate | 2013 |
| Shavings Innovations Ltd | Agriculture & fishing | 2014 |
| Shaw Heath Estates Limited | Real estate | 2017 |
| Sheff Hall Management Company Limited | Households | 2013 |
| Sheppard's Flock Ltd | Hospitality | 2015 |
| Sheq Insights Ltd | Public administration | 2026 |
| Shergold Associates Ltd | Professional & scientific | 2018 |
| Sherhod Limited | Professional & scientific | 2025 |
| Sherman Estates Limited | Professional & scientific | 2019 |
| Shernfold Gardens Limited | Households | 1986 |
| Shernfold Park Residents Association Limited | Real estate | 1978 |
| Sherpa Holdings Ltd | Financial services | 2019 |
| Shevski Limited | Professional & scientific | 2015 |
| Shhh You’Re Beautiful Ltd | Other services | 2022 |
| Shhh... Ltd | Other services | 2019 |
| Shih Solutions Ltd | Information & communication | 2025 |
| Shine Design and Decoration Limited | Professional & scientific | 2019 |
| Shinobi Associates Limited | Professional & scientific | 2012 |
| Shirley Rolfe Limited | Hospitality | 2017 |
| Shloksha Ltd | Manufacturing | 2021 |
| SHM Holdings Limited | Professional & scientific | 1982 |
| Shona Beats Ltd | Professional & scientific | 2024 |
| Shop at Www.Teas.Co.Uk Ltd | Wholesale & retail | 2025 |
| Shopesy Ltd | Wholesale & retail | 2026 |
| Shoreham Park Pharma Limited | Wholesale & retail | 2026 |