| Crazy Beautiful World CIC | Education | 2021 |
| Crinan Consultancy Limited | Professional & scientific | 2025 |
| CRJ Enterprises Ltd | Arts & recreation | 2017 |
| Crop Community Limited | Wholesale & retail | 2024 |
| Crow Crag Studios Ltd | Information & communication | 2023 |
| CRU Events Limited | Other services | 2012 |
| CRU Global Ltd | Administrative & support | 2020 |
| Culverlane Ltd | Professional & scientific | 2017 |
| Curry Totnes Limited | Hospitality | 2024 |
| CYI Marketing Services LLP | | 2011 |
| D & L Car Sales Ltd | Wholesale & retail | 2017 |
| D N Evans Limited | Construction | 2012 |
| D. & J. Eastley Limited | Administrative & support | 1978 |
| D3 Consulting Limited | Professional & scientific | 2011 |
| Daaam!!! Records!!! Ltd | Information & communication | 2013 |
| Dajo Developments Limited | Construction | 2025 |
| Damisports Ltd | Professional & scientific | 2021 |
| Dancingstrong Movement Laboratory C.I.C. | Arts & recreation | 2009 |
| Dangerous Records Limited | Information & communication | 1989 |
| Danny Scroggins Holdings Limited | Financial services | 2021 |
| Dareco Company Limited | Construction | 2010 |
| Dark Electrical Services Ltd | Construction | 2009 |
| Darren Biggs Construction Ltd | Construction | 2017 |
| Dart Fabrication Ltd | Construction | 2015 |
| Dart Investments (Totnes) Limited | Financial services | 2023 |
| Dart Marine Ltd | Manufacturing | 2024 |
| Dart Motors Limited | Wholesale & retail | 2012 |
| Dart Property Services Ltd | Construction | 2010 |
| Dartforest Limited | Professional & scientific | 2015 |
| Dartington Accommodation and Catering Services Limited | Extraterritorial | 1975 |
| Dartington Development Group Ltd | Construction | 2018 |
| Dartington Hall Pension Trustees Limited | Financial services | 2009 |
| Dartington Hall Trust(The) | Arts & recreation | 1980 |
| Dartington Mill CIC | Agriculture & fishing | 2019 |
| Dartington Repair Cafe CIC | Other services | 2024 |
| Dartlets Ltd. | Real estate | 1996 |
| Dartlings & Co Limited | Hospitality | 2026 |
| Dartmoor Sheepskins Ltd | Wholesale & retail | 2021 |
| Dartmouth Eats Limited | Real estate | 2018 |
| Dartmouth Green Limited | Real estate | 2008 |
| Dartmouth Outboard Clinic Ltd | Manufacturing | 2013 |
| Dartrail Consulting Limited | Professional & scientific | 2017 |
| Dartside Boatworks Limited | Manufacturing | 2010 |
| Dartside Developments Ltd | Real estate | 2026 |
| Databeet Limited | Professional & scientific | 2024 |
| Datum Alloys Group Limited | Financial services | 2019 |
| Datum Alloys Ltd | Manufacturing | 1993 |
| Datum Capital Limited | Financial services | 2016 |
| David Banks Consultancy Limited | Financial services | 2017 |
| David Scanlan and Associates Limited | Real estate | 1990 |
| Davymik Limited | Professional & scientific | 1999 |
| Daymark Holdings Ltd | Real estate | 2025 |
| Dayment Plumbing and Heating Ltd | Construction | 2024 |
| DB Accountants Ltd | Professional & scientific | 2013 |
| Deadly Night Shade Limited | Wholesale & retail | 2019 |
| Deaf Choices UK Limited | Education | 1980 |
| Debbie Higgins, BSC (Hons), Atii, CYF | Professional & scientific | 2003 |
| Debbie Macpherson Atelier Limited | Manufacturing | 2021 |
| Deeble Holdings Limited | Wholesale & retail | 2021 |
| Deep Time Walk C.I.C. | Education | 2016 |
| Deeply Human Design Ltd | Information & communication | 2023 |
| Defacto Films Limited | Information & communication | 2004 |
| Defacto Motion Ltd | Information & communication | 2022 |
| Demaro Ltd | Professional & scientific | 2013 |
| Denyer House Management Limited | Households | 2000 |
| Design on Impulse Limited | Professional & scientific | 2015 |
| Devon & Dorset Removals Limited | Transport & logistics | 2016 |
| Devon and Cornwall Farmers Limited | Real estate | 2001 |
| Devon Ceramics (Contracts) Limited | Manufacturing | 2009 |
| Devon Holiday Cottages Limited | Hospitality | 2011 |
| Devon Organic Skincare Limited Liability Partnership | | 2025 |
| Devon Renovators Ltd | Construction | 2024 |
| Devon Smart Repair SW Ltd | Wholesale & retail | 2025 |
| Devon Sports Boats Limited | Manufacturing | 2022 |
| Devon Wild Eco Retreats CIC | Other services | 2026 |
| Devoncraft UK Limited | Wholesale & retail | 2001 |
| Dialogue Consultants Limited | Education | 2013 |
| Digital Communities Limited | Information & communication | 2023 |
| Digital Experience Limited | Information & communication | 1994 |
| Disability Focus | Health & social care | 2007 |
| Discbell Limited | Information & communication | 1988 |
| Divine INK Ltd | Other services | 2013 |
| DLC Investments Ltd | Real estate | 2017 |
| DOC Vitals Ltd | Wholesale & retail | 2024 |
| Does the Pictures Studio Ltd | Administrative & support | 2023 |
| Dogleg Theatre Ltd | Arts & recreation | 2023 |
| Dove Renewables Ltd | Energy | 2016 |
| DR FRY & Co Limited | Administrative & support | 2021 |
| Drift Record Shop Limited | Wholesale & retail | 2019 |
| Driftsands LLP | | 2013 |
| Dsbb Ltd | Real estate | 2024 |
| Duchy of Somerset Estates Limited | Real estate | 2013 |
| Dudley Projects Partnership Limited | Professional & scientific | 2012 |
| Duke Capital Limited | Financial services | 2020 |
| Dying With Grace C.I.C. | Health & social care | 2023 |
| E C Surveyors LLP | | 2017 |
| Earth Wrights Limited | Manufacturing | 2008 |
| Earth.Food.Love Ltd. | Wholesale & retail | 2016 |
| Earthlinks UK | Information & communication | 2008 |
| East Gate Bookshop Ltd | Wholesale & retail | 2020 |