| Smart Choice Events Ltd | Arts & recreation | 2022 |
| Smile Motorist Limited | Financial services | 2012 |
| Smith Partnership Limited | Agriculture & fishing | 2025 |
| Smith White Limited | Professional & scientific | 2020 |
| Smith's Jewellers Ltd | Wholesale & retail | 2015 |
| Smugglers TUB Ltd | Manufacturing | 2022 |
| SO Solid Sando Limited | Hospitality | 2025 |
| Socho Limited | Wholesale & retail | 2026 |
| Social Landscapes Community Interest Company | Real estate | 2015 |
| Solutionary Futures Ltd | Professional & scientific | 2022 |
| Soma CI Ltd | Arts & recreation | 2025 |
| Somerset Rural Estates LLP | | 2013 |
| Sonic Hearth Community Music CIC | Education | 2026 |
| Sorting Room Studios LLP | | 2022 |
| Soul Source Events Ltd | Hospitality | 2023 |
| Sound Spaces Production and Consulting Ltd | Information & communication | 2015 |
| Soundart Radio Limited | Information & communication | 2007 |
| South Devon Auto Repairs Limited | Wholesale & retail | 2004 |
| South Devon Campervans Ltd | Wholesale & retail | 2022 |
| South Devon Carpet Company Ltd | Wholesale & retail | 2025 |
| South Devon Cottage Holidays Limited | Real estate | 2021 |
| South Devon Sound CIC | Information & communication | 2013 |
| South Gate Lamb North (Apartments) Limited | Households | 2008 |
| South Gate Lamb North Limited | Households | 2008 |
| South Hams Citizens Advice Bureau | Information & communication | 2002 |
| South Hams Community Action Ltd | Other services | 2007 |
| South Hams Family Funerals Ltd | Other services | 2024 |
| South Hams Vehicle Hire Ltd | Transport & logistics | 2018 |
| South West 4X4 Ltd | Wholesale & retail | 2021 |
| South West Driver Services Ltd | Transport & logistics | 2015 |
| South West Holdings Ltd | Real estate | 2025 |
| South West Marine Consultants Limited | Professional & scientific | 2020 |
| South West Scaffolding Limited | Construction | 2004 |
| Southfield Windows Ltd | Manufacturing | 2012 |
| Southwest Hearing Ltd | Wholesale & retail | 2019 |
| Southwest Images Ltd | Professional & scientific | 2014 |
| Sowton Weir Ltd | Energy | 2011 |
| Spencer Projects Ltd | Real estate | 2023 |
| Sportiva Events Ltd | Arts & recreation | 2009 |
| Sprouted Ltd | Manufacturing | 2025 |
| ST Christopher’S Preparatory School & Nursery Limited | Education | 2014 |
| ST Clements Terrace Management Company Limited | Households | 2020 |
| ST Peters Quay Residents Limited | Real estate | 2022 |
| ST. Johns Hall (Totnes) Management Company Limited | Households | 1979 |
| Stable Films Limited | Information & communication | 2007 |
| Stag & Seer Limited | Wholesale & retail | 2020 |
| Stanborough Court Company Limited | Households | 2004 |
| Start Point Productions Limited | Information & communication | 2015 |
| Staverton Mill Management Company Limited | Households | 2010 |
| Stellaria Media Ltd. | Information & communication | 2019 |
| Stephen Evans Car Limited | Wholesale & retail | 2018 |
| Stepping Stones Totnes CIC | Hospitality | 2021 |
| Steward Archive Ltd | Arts & recreation | 2025 |
| Stoke Gabriel PUB Co Ltd | Hospitality | 2025 |
| Stone & Steam Community Sauna CIC | Health & social care | 2025 |
| Storey Technology (2022) Limited | Information & communication | 2022 |
| Storey Technology Limited | Information & communication | 1996 |
| Strashleigh Estates Ltd. | Real estate | 2017 |
| Strowan Ltd | Real estate | 2021 |
| Structure Dart Ltd | Professional & scientific | 2025 |
| Studio FBD Ltd | Professional & scientific | 2025 |
| Studio Jago Limited | Information & communication | 2021 |
| Studio Leap Ltd | Professional & scientific | 2022 |
| Sult Ltd | Professional & scientific | 2024 |
| Super Strike (Fundraisers) Limited | Arts & recreation | 2013 |
| Superior Properties (Southern) Limited | Real estate | 1960 |
| Supermarket Design Limited | Information & communication | 2022 |
| Superyachttender Ltd | Professional & scientific | 2020 |
| Surface Systems Limited | Construction | 1997 |
| Susan Harter Studios Ltd | Manufacturing | 2025 |
| Sustainable Bidco Limited | Extraterritorial | 2021 |
| Sustainable Topco Limited | Extraterritorial | 2021 |
| Sutherland Rhodes Limited | Real estate | 2011 |
| SW Pools & Leisure Ltd | Construction | 2021 |
| Swift Fundraising Limited | Administrative & support | 2016 |
| Synescent Ltd | Information & communication | 2014 |
| Sypo Land & Developments Ltd | Construction | 2015 |
| T P Maynard Holdings Ltd | Professional & scientific | 2023 |
| T&E Property Renovations Limited | Construction | 2021 |
| T2 Properties Limited | Construction | 2018 |
| Tailwind Trading Ltd | Professional & scientific | 2025 |
| Talea ORA Consulting Ltd | Professional & scientific | 2018 |
| Talea ORA Lettings Ltd | Real estate | 2021 |
| Talk Action CIC | Education | 2008 |
| Tally HO Hospitality Ltd | Hospitality | 2018 |
| Tamar Bespoke Financial Services Limited | Professional & scientific | 2021 |
| Tamarind Tree Totnes Ltd | Hospitality | 2022 |
| Tanner Bates Leather Limited | Manufacturing | 2022 |
| Taramatty Ltd | Hospitality | 2023 |
| Taylor Earnshaw Limited | Real estate | 2012 |
| TB Hospitality Ltd | Hospitality | 2024 |
| Tecnic Paint Inspections Ltd | Construction | 2014 |
| Tectonic Fresco Ltd | Information & communication | 2024 |
| Teign Enterprises Limited | Manufacturing | 2017 |
| TEN Thousand Banzais Ltd | Hospitality | 2017 |
| Tensk Limited | Construction | 2014 |
| THE Academies for Character and Excellence | Education | 2016 |
| THE Banquet Boat River Dart Ltd | Hospitality | 2022 |
| THE Bickley Mill Inn Limited | Hospitality | 2012 |
| THE Black Bird Collective Ltd | Arts & recreation | 2025 |