| RCY Limited | Wholesale & retail | 2002 |
| RDF Business Services Limited | Professional & scientific | 2017 |
| Reach Charity Limited | Other services | 2009 |
| Red Original Limited | Extraterritorial | 2017 |
| Red Paddle Co Limited | Wholesale & retail | 1978 |
| Red Paddle Holdings Limited | Extraterritorial | 2015 |
| Redlands Estate Limited | Extraterritorial | 2014 |
| Redpost Equestrian Ltd | Wholesale & retail | 2002 |
| Redpost Media Limited | Professional & scientific | 2014 |
| Redwood Mana Limited | Real estate | 2021 |
| Redwood River School Limited | Education | 2025 |
| Regenfarm Limited | Agriculture & fishing | 2015 |
| Reig Jofre UK Limited | Manufacturing | 2014 |
| Reimaginet Limited | Information & communication | 2022 |
| Rennolds Surveyors Limited | Professional & scientific | 2012 |
| Resilient Lives CIC | Education | 2020 |
| Resilient Young Minds CIC | Health & social care | 2026 |
| Rewylding CIC | Health & social care | 2025 |
| RH Photography Limited | Professional & scientific | 2014 |
| Ringham Properties Limited | Real estate | 1966 |
| RIV Advisory Ltd | Professional & scientific | 2023 |
| Riverford Farm Dairies Limited | Manufacturing | 1999 |
| Rivergate Property Limited | Hospitality | 2016 |
| Riverwalk Estates Limited | Real estate | 2000 |
| Riviera Brewing Company Limited | Manufacturing | 2014 |
| Rlarm Holdings Limited | Financial services | 2022 |
| Robin Cook Consulting Ltd | Information & communication | 2025 |
| Rock the Boat Activities Ltd | Arts & recreation | 2017 |
| Rock the Boat Training Ltd | Education | 2024 |
| Rocketbox Ltd | Information & communication | 2011 |
| Roderick James Architects LLP | | 2002 |
| Rodger Jackman Developments Limited | Construction | 2018 |
| Romana Homes Limited | Real estate | 2007 |
| Rose Farm Cottages Limited | Administrative & support | 2014 |
| Rosecroft Homes Limited | Real estate | 2020 |
| Rosehip Nursing Ltd | Health & social care | 2023 |
| Rosso Totnes Ltd | Wholesale & retail | 2023 |
| Rosstot Limited | Administrative & support | 2020 |
| Rotal Limited | Wholesale & retail | 2014 |
| Rowes Farm Management Company Limited | Households | 2003 |
| Rowler MFG Ltd | Construction | 2025 |
| RPA 2000 | Professional & scientific | 2000 |
| Ruby Rands Events Ltd | Administrative & support | 2023 |
| Ruby Totnes Ltd | Hospitality | 2025 |
| Rudolf Steiner School (South Devon) Limited | Education | 1983 |
| Russell ROW Ltd | Financial services | 2020 |
| S. a. Mingo Ltd | Real estate | 2021 |
| Safe Able & Fair Recruitment Ltd | Arts & recreation | 2023 |
| Safeguarding Guru Limited | Education | 2024 |
| Safeguarding Network Limited | Education | 2017 |
| Safesite Training and Consultancy Limited | Education | 2024 |
| Sainter (Investments) Limited | Real estate | 1939 |
| Sakura Counselling South West LLP | | 2023 |
| Salcombe Embroiderers Limited | Manufacturing | 2005 |
| Sanctuary Coffee Limited | Wholesale & retail | 2021 |
| Sands School | Education | 1988 |
| Sandwell (Devon) Limited | Hospitality | 1964 |
| Sara Martin Media Limited | Administrative & support | 2010 |
| Sarah Gillespie Limited | Arts & recreation | 2014 |
| Sawdye & Harris (Auctioneers, Valuers & Surveyors) Ltd | Professional & scientific | 2004 |
| School Farm Community Supported Agriculture C.I.C. | Agriculture & fishing | 2013 |
| Schumacher College Foundation | Professional & scientific | 1991 |
| Scope Communications UK Limited | Manufacturing | 1983 |
| Scope Management UK Ltd | Financial services | 2023 |
| Scorpia Swim Limited | Wholesale & retail | 2021 |
| SDM Trading Ltd | Financial services | 2018 |
| Sdqss Limited | Professional & scientific | 2025 |
| Sea Change Festivals Limited | Arts & recreation | 2016 |
| Seacroft Investments Ltd | Real estate | 2020 |
| Sebmoc Limited | Wholesale & retail | 2023 |
| Selkie Swimwear Ltd | Manufacturing | 2014 |
| Semaphore Trading Ltd | Financial services | 2024 |
| Semsûr Limited | Hospitality | 2025 |
| Sequoia Contractor Solutions Ltd | Information & communication | 2012 |
| Sequoia Contractors Ltd | Real estate | 2009 |
| Sergio Diaz Tech LAB Limited | Information & communication | 2025 |
| Sewl Productions Ltd | Information & communication | 2021 |
| SGK Property Investments Ltd | Construction | 2026 |
| Shakman Limited | Health & social care | 2025 |
| Sharpham Partnership Limited | Manufacturing | 1992 |
| Sharpham Trust(The) | Education | 1982 |
| Sheplegh Court Residents Company Limited | Households | 1988 |
| Sherford Community Land Trust Limited | Households | 2018 |
| SHG Limited | Households | 1987 |
| Shiatsu for Change Community Interest Company | Education | 2019 |
| Shinners Bridge Garden Machinery Ltd | Manufacturing | 2018 |
| Shirley Head Travel Management Ltd | Administrative & support | 2016 |
| Signature Classics Limited | Wholesale & retail | 2025 |
| Simba Fostering Ltd | Health & social care | 2026 |
| Simon Orchard Financial Services Limited | Financial services | 2014 |
| Simpson Farm Management Ltd | Agriculture & fishing | 2025 |
| Sirius Records Ltd | Information & communication | 2026 |
| Sivasathyaa Limited | Real estate | 2016 |
| SJM Devon Ltd | Financial services | 2024 |
| SKH Enterprise Ltd | Wholesale & retail | 2022 |
| Skilco Ltd | Construction | 2022 |
| Sky Blue (Devon) Limited | Financial services | 2019 |
| Slender Loris Films Limited | Information & communication | 2017 |
| SM 2025 Ltd | Professional & scientific | 2021 |
| Small Folk Ltd | Wholesale & retail | 2021 |