| Rural Activities & Luxury Travel Ltd | Transport & logistics | 2019 |
| Rural Arts North Yorkshire | Arts & recreation | 2000 |
| Rural Arts Trading Limited | Arts & recreation | 2014 |
| Rusty Pete Ltd | Information & communication | 2025 |
| RWS Bodyworks Limited | Wholesale & retail | 2003 |
| RWS Light Commercials Ltd | Wholesale & retail | 2020 |
| Rydenor Holdings Limited | Real estate | 2024 |
| S & N Properties York Ltd | Real estate | 2025 |
| S Brew Electrical & Engineering Ltd | Professional & scientific | 2020 |
| S Buxton Ltd | Wholesale & retail | 2018 |
| S C E Construction Ltd | Construction | 2019 |
| S C E Renovations Ltd | Construction | 2025 |
| S K Contracting (Yorkshire) Limited | Construction | 2001 |
| S K Projects (Yorkshire) Limited | Real estate | 2005 |
| S. Huntley Limited | Agriculture & fishing | 1963 |
| S.M.S. (Salcombe) Limited | Wholesale & retail | 2002 |
| Sadie and FLO Ltd | Wholesale & retail | 2020 |
| Safehalo Ltd | Professional & scientific | 2025 |
| Safeloft Ltd | Construction | 2021 |
| Saferspace IO Ltd | Professional & scientific | 2023 |
| Safety Zone (Consulting) Limited | Professional & scientific | 2002 |
| Salcombe Marine Storage (Lincombe) Limited | Manufacturing | 2021 |
| Salcombe Marine Storage (Malborough) Limited | Manufacturing | 2021 |
| Saltbox 17 Ltd | Construction | 2017 |
| Samo International Publishing Limited | Information & communication | 2024 |
| Sandholme Properties Limited | Real estate | 2016 |
| Sandhutton Growers Limited | Agriculture & fishing | 2002 |
| Saxon House Residences Limited | Hospitality | 2016 |
| SAY IT in Stitch Ltd | Manufacturing | 2026 |
| SB & KB Contractors Ltd. | Administrative & support | 2013 |
| SBS Property Limited | Real estate | 2002 |
| SC Comms Engineering Limited | Professional & scientific | 2019 |
| Scatchards Electrical Ltd | Construction | 2013 |
| Scawton Sawmill Limited | Agriculture & fishing | 2012 |
| Scorpion Ribs Limited | Professional & scientific | 2019 |
| Scott Roberts Limited | Financial services | 1996 |
| Scriven Aviation Limited | Administrative & support | 2023 |
| Scriven Group Limited | Financial services | 2023 |
| Scriven Limited | Real estate | 2008 |
| Securedstylegates Ltd | Manufacturing | 2024 |
| Sedgewell Barn Limited | Hospitality | 2017 |
| Seedlings Montessori Childcare Ltd | Education | 2014 |
| Selectivecovers Limited | Wholesale & retail | 2000 |
| Serendipity Dogs Ltd | Other services | 2023 |
| Seven H Construction Limited | Construction | 2024 |
| Severfield (Design & Build) Limited | Manufacturing | 2000 |
| Severfield Commercial & Industrial Limited | Construction | 1991 |
| Severfield Infrastructure Limited | Manufacturing | 2004 |
| Severfield International Limited | Construction | 1987 |
| Severfield Modular Solutions Limited | Construction | 2018 |
| Severfield Nuclear & Infrastructure Limited | Construction | 1982 |
| Severfield PLC | Manufacturing | 1983 |
| Shane Hardy Tiling Limited | Construction | 2021 |
| Shane Hird Ltd | Transport & logistics | 2022 |
| Shawgas Limited | Extraterritorial | 2002 |
| Shelldrake Limited | Wholesale & retail | 2009 |
| Shepherd's Purse Cheeses Holdings Limited | Financial services | 2025 |
| Shepherd's Purse Cheeses Limited | Manufacturing | 1997 |
| Sherwoods Group Limited | Wholesale & retail | 2020 |
| Shine Automotive Ltd | Wholesale & retail | 2022 |
| Shires Land & Property (Northern) Limited | Construction | 2005 |
| Shirley & Proctor Limited | Manufacturing | 1960 |
| Shirley Killamarsh Limited | Manufacturing | 1998 |
| Sidai Africa Limited | Financial services | 2010 |
| Sigeta Limited | Information & communication | 2026 |
| Silly Little Women Ltd | Wholesale & retail | 2020 |
| Silton Developments Limited | Construction | 2023 |
| Simon & Becky Ltd | Wholesale & retail | 2011 |
| Simon Parker Bespoke Joinery Ltd | Other services | 2016 |
| Skelwith Group Limited | Real estate | 2007 |
| Skiphutton Limited | Agriculture & fishing | 2023 |
| Sky Cottages Ltd | Hospitality | 2024 |
| Skyline Resorts Limited | Financial services | 2018 |
| Skyline Talent Management Limited | Professional & scientific | 2026 |
| Skysteel Structures Ltd | Construction | 2013 |
| SL Palliser Joinery Limited | Construction | 2015 |
| Slurrybag Ltd | Agriculture & fishing | 2024 |
| SM Gardening Limited | Administrative & support | 2011 |
| Sofa & Co Thirsk Ltd | Wholesale & retail | 2018 |
| Soil Treatment UK Limited | Water & waste | 2023 |
| Somebarmaid Limited | Wholesale & retail | 2023 |
| Sonisounds Ltd | Information & communication | 2024 |
| Sonneveld UK Limited | Manufacturing | 2016 |
| Soper Consultancy Ltd | Information & communication | 2022 |
| Southgate Fisheries Ripon Ltd | Hospitality | 2025 |
| Southlands Court (Sowerby) Management Limited | Households | 2005 |
| Sowerby Management Company Limited | Professional & scientific | 2008 |
| Special Steel Sections Holdings Limited | Professional & scientific | 2006 |
| Special Steel Sections Limited | Manufacturing | 2000 |
| Specialised Pipeline Services Limited | Manufacturing | 2019 |
| Speedy Bits Ltd | Information & communication | 2023 |
| Speedy IP Services Ltd | Information & communication | 2023 |
| Sports Field Design Limited | Construction | 2020 |
| Sports Logistics Limited | Transport & logistics | 2023 |
| Sprigwell Limited | Information & communication | 2026 |
| Spring Theory Ltd | Arts & recreation | 2025 |
| Springfield Garage (Thirsk) Limited | Wholesale & retail | 2003 |
| SQ Aesthetics Limited | Health & social care | 2025 |
| SQ Feet Limited | Real estate | 2010 |
| Stapylton Property Investments Ltd | Real estate | 2022 |