| Severn Point Automotive (Tewkesbury) Ltd | Wholesale & retail | 2023 |
| Severn Point Automotive Ltd | Wholesale & retail | 2020 |
| Severnside Motors Ltd | Wholesale & retail | 2024 |
| Severnside Security Ltd | Administrative & support | 2013 |
| SFP Store Ltd | Wholesale & retail | 2009 |
| SH Professional Services Ltd | Professional & scientific | 2024 |
| SH Retail City of London Ltd | Hospitality | 2026 |
| SH Retail Investments Ltd | Hospitality | 2020 |
| Shankar World Ltd | Wholesale & retail | 2025 |
| SHB2S Ltd | Other services | 2019 |
| Sheen Cleaning Services Limited | Administrative & support | 2022 |
| Shepherds Retreat Property Ltd | Real estate | 2025 |
| Sherdons Golf Centre @ Tredington Limited | Arts & recreation | 2014 |
| Sherdons Golf Limited | Arts & recreation | 2001 |
| Shift Auto’S Ltd | Wholesale & retail | 2025 |
| Shillofad Limited | Agriculture & fishing | 1995 |
| Shortlast Limited | Real estate | 1997 |
| Shrec Ltd | Professional & scientific | 2010 |
| Shuthonger Management Limited | Households | 2019 |
| Sibling Social Ltd | Hospitality | 2022 |
| Sibling Spirits Ltd | Wholesale & retail | 2025 |
| Sigma Close Catering Limited | Hospitality | 2024 |
| Signatrol Limited | Manufacturing | 2003 |
| Signum Technology Limited | Extraterritorial | 2012 |
| Silencio Pictures Limited | Administrative & support | 2026 |
| Silicoln Valley Ltd | Professional & scientific | 2021 |
| Silly Salmons Ltd | Wholesale & retail | 2023 |
| Silverfox Search Ltd | Professional & scientific | 2017 |
| Silvflame Limited | Manufacturing | 2016 |
| Simeon's Movers Ltd | Transport & logistics | 2024 |
| Simon Gibson Mastering Limited | Information & communication | 2025 |
| Simple Key Homes Ltd | Real estate | 2023 |
| Simply PAY Weekly Ltd | Administrative & support | 2019 |
| Simply Safaris Limited | Administrative & support | 2004 |
| Single Source Recruitment Limited | Administrative & support | 2018 |
| SIS Transport Logistics Ltd | Transport & logistics | 2025 |
| Site Pro Group Limited | Wholesale & retail | 2022 |
| Site Pro Safety Limited | Wholesale & retail | 2023 |
| Site Pro Survey Limited | Extraterritorial | 2022 |
| SJ Lansdowne Ltd | Financial services | 2017 |
| SJH Real Estate Group Ltd | Real estate | 2024 |
| SKI Tyres (Hereford) Limited | Wholesale & retail | 1991 |
| SKI Tyres (Holdings) Limited | Financial services | 2024 |
| SKI Tyres Cheltenham Limited | Wholesale & retail | 1986 |
| SKI Tyres Gloucester Limited | Wholesale & retail | 1989 |
| SKI Tyres Limited | Wholesale & retail | 1994 |
| Skills Ladder Limited | Education | 2013 |
| Skyra Holdings Limited | Real estate | 2025 |
| Skyra Property Limited | Health & social care | 2024 |
| Slatter E-Commerce Limited | Wholesale & retail | 2024 |
| Slayyer Consultancy Limited | Information & communication | 1999 |
| SM Metal Recycling Limited | Extraterritorial | 2007 |
| Smart Admin Solutions Ltd | Administrative & support | 2023 |
| Smart Retirement Financial Services Ltd | Financial services | 2025 |
| Smartsurvey Ltd | Information & communication | 2003 |
| SME Coaching Worcestershire Ltd | Professional & scientific | 2022 |
| Snitchy Ltd | Information & communication | 2024 |
| Snookerspex Ltd | Wholesale & retail | 2017 |
| Soar Newco Limited | Financial services | 2013 |
| Social Research Builders Ltd | Professional & scientific | 2024 |
| Socialhit Ltd | Professional & scientific | 2022 |
| Soda Inc. Ltd | Extraterritorial | 2021 |
| Sola Pergolas Ltd | Wholesale & retail | 2025 |
| SOLARGO2 Limited | Wholesale & retail | 2020 |
| Solstice Distribution Limited | Wholesale & retail | 2019 |
| Soludent Ltd | Health & social care | 2017 |
| Sommet Limited | Financial services | 2022 |
| Sonicbond Publishing Limited | Information & communication | 2017 |
| Sophie Lobley Limited | Education | 2024 |
| Sorbus Property Ltd | Real estate | 2023 |
| Sound Agents & Management Limited | Administrative & support | 2017 |
| Souplesse Cycling Limited | Wholesale & retail | 2024 |
| Sourdough House Limited | Manufacturing | 2002 |
| Southery Farms Limited | Agriculture & fishing | 1943 |
| Sparks R US Electrical Limited | Construction | 2009 |
| Spectrum IT Consultancy Ltd | Information & communication | 2019 |
| Sprint Media Ltd | Professional & scientific | 2007 |
| Square 2 Property Limited | Real estate | 2023 |
| SR Interim HSE Management Ltd | Administrative & support | 2019 |
| SR Morgan Ltd | Transport & logistics | 2017 |
| SRA Cyber Ltd | Wholesale & retail | 2024 |
| Ssec Electrical Ltd | Construction | 2024 |
| Ssec Group Ltd | Financial services | 2024 |
| SSF South West Ltd | Other services | 2022 |
| Stanton HR Ltd | Administrative & support | 2012 |
| Stanton Properties Ltd | Real estate | 2025 |
| Stanway Real Estate Limited | Professional & scientific | 2004 |
| Star Hydraulics Limited | Manufacturing | 1984 |
| Status Holdings Limited | Professional & scientific | 2005 |
| Status Instruments Limited | Manufacturing | 1982 |
| Steaming Mugs (Tewkesbury) Ltd | Hospitality | 2024 |
| Steertrak (UK) Ltd | Wholesale & retail | 2005 |
| Stemco Ltd | Professional & scientific | 2025 |
| Stephen Clayton Limited | Wholesale & retail | 2019 |
| Stirling Fosse Wealth Management Limited | Financial services | 2024 |
| Stoke Park Properties Ltd | Real estate | 2019 |
| Storrer Antiques Limited | Wholesale & retail | 2025 |
| Strand Services (Whitchurch) Limited | Hospitality | 1991 |
| Strata Finance Club Ltd | Financial services | 2025 |
| Strategy at Work Limited | Professional & scientific | 2009 |