| Dudge & Dale Motors Limited | Wholesale & retail | 2012 |
| Dudley House (Wootton Bassett) Management Company Limited | Households | 1980 |
| Duka Homes Ltd | Construction | 2024 |
| DUN Mill Construction Ltd | Construction | 2012 |
| DUN Mill Group Limited | Extraterritorial | 2023 |
| Duncan Hire Limited | Administrative & support | 2005 |
| Duncan Wolage Architects Limited | Professional & scientific | 2019 |
| DUO H Solutions Limited | Administrative & support | 2025 |
| Durals Ltd | Other services | 2020 |
| Durand Consultancy Ltd | Other services | 2019 |
| Dust Bunnie Cleaning Ltd | Administrative & support | 2017 |
| Dutchford Limited | | 1979 |
| Dutton Haulage Limited | Transport & logistics | 2003 |
| DV Services and Consulting Ltd | Professional & scientific | 2025 |
| Dvive Limited | Information & communication | 2022 |
| DW Architech Limited | Professional & scientific | 2020 |
| DW Motoring Limited | Transport & logistics | 2016 |
| Dwellow Limited | Wholesale & retail | 2023 |
| Dwellyn HM Ltd | Real estate | 2023 |
| DWG Inspection Services Ltd | Construction | 2020 |
| DWL Electrical Ltd | Construction | 2026 |
| DWR Design & Build Limited | Construction | 2013 |
| DWS Holdings (Swindon) Ltd | Financial services | 2021 |
| Dwtcsolutions Ltd | Health & social care | 2026 |
| DXB Systems Ltd | Information & communication | 2012 |
| DXG Services Ltd | Construction | 2024 |
| Dydale Ltd | Professional & scientific | 2026 |
| Dyme Care Ltd | Health & social care | 2023 |
| Dynamic Autocare Swindon Limited | Wholesale & retail | 2018 |
| Dynamic Cleaning Services Limited | Administrative & support | 2004 |
| Dynamic Motion Systems Limited | Manufacturing | 2010 |
| Dynamic Tutors LLP | | 2024 |
| Dynamisys Limited | Information & communication | 2001 |
| Dynasty Drinks Ltd | Wholesale & retail | 2026 |
| Dynaxo Limited | Construction | 2015 |
| Dyollimramcm Limited | Wholesale & retail | 1990 |
| E & J TS Property Limited | Real estate | 2023 |
| E & N Recruitment Limited | Transport & logistics | 2021 |
| E and M Homes Ltd | Real estate | 2019 |
| E Gribbin Ltd | Professional & scientific | 2022 |
| E H Plant Limited | Administrative & support | 2023 |
| E L Moore Ltd | Health & social care | 2024 |
| E&A Prestige Bodyshop Ltd | Wholesale & retail | 2024 |
| E&J Engineering Solutions Ltd. | Professional & scientific | 2015 |
| E&J Limited | Wholesale & retail | 2019 |
| E&M Design and Build Limited | Construction | 2020 |
| E&R Rental Ltd | Real estate | 2025 |
| E&S Limited | Hospitality | 2019 |
| E'S Garage Ltd | Wholesale & retail | 2025 |
| E-Align Specialist Solutions Ltd | Wholesale & retail | 2019 |
| E-Go Mopeds Limited | Administrative & support | 2020 |
| E-Joylad Business Solutions Limited | Wholesale & retail | 2025 |
| E-Mex Home Funding Limited | Financial services | 1987 |
| E-Motion Electric Vehicle Company Limited | Wholesale & retail | 2009 |
| E-Nutrition Limited | Wholesale & retail | 2014 |
| E.D Electrics Ltd | Construction | 2022 |
| E.G Digital IT Services Limited | Information & communication | 2019 |
| E.P. Keogh Contractors Ltd. | Construction | 1995 |
| E.V.G-78 Ltd | Administrative & support | 2017 |
| E.W. Beard (Land) Limited | Extraterritorial | 1947 |
| E.W. Beard Limited | Construction | 1973 |
| E6 Solutions Ltd | Administrative & support | 2025 |
| EAG Performance Ltd | Professional & scientific | 2024 |
| Eagle Assets UK Ltd | Real estate | 2020 |
| Eagle Glade Management Limited | Households | 2006 |
| Eagle Star (Leasing) Limited | Real estate | 1983 |
| Eagle Star Group Services Limited | Extraterritorial | 1989 |
| Eagle Star Holdings Limited | Professional & scientific | 1979 |
| Eaglestoneuk Limited | Professional & scientific | 2006 |
| EAJ Medical Ltd | Health & social care | 2011 |
| Earnest Support Care Ltd | Health & social care | 2024 |
| Earth N Ocean Limited | Manufacturing | 1999 |
| Earthmoving Extras Limited | Wholesale & retail | 2019 |
| Earwax Removal by JAN Ltd | Health & social care | 2024 |
| Easey Fitness Limited | Other services | 2025 |
| Easey Health Holdings Limited | Financial services | 2025 |
| Easey Health Limited | Health & social care | 2019 |
| East 55TH Ltd | Households | 2026 |
| East Home Properties Limited | Real estate | 2015 |
| East House Consulting Limited | Information & communication | 2017 |
| East Kent Theatre Arts LLP | | 2022 |
| East Ridge Tracking Ltd | Information & communication | 2025 |
| East Street Securities Limited | Construction | 2008 |
| East Thing Ltd | Information & communication | 2014 |
| East Wiltshire Partners Limited | Real estate | 2025 |
| Eastbax Limited | Hospitality | 2018 |
| Eastbrook Farm Organic Fast Food Limited | Hospitality | 2004 |
| Eastbrook Farm Organic Meats Limited | Wholesale & retail | 1997 |
| Eastcon Shutters Ltd | Construction | 2021 |
| Eastcott Estates Limited | Administrative & support | 2019 |
| Eastcott Seven Leaseholders Association Limited | Households | 2000 |
| Easterton Services Limited | Professional & scientific | 2023 |
| Eastrop Barns Management Services Limited | Households | 2025 |
| Eastwood Store PVT Ltd | Wholesale & retail | 2026 |
| Easy Care PVT Ltd | Administrative & support | 2022 |
| Easy Invest Properties Ltd | Administrative & support | 2022 |
| Easyliving Investments Limited | Real estate | 2019 |
| Easyliving Property Limited | Households | 2019 |
| Easymoove (Holdings) UK Ltd | Real estate | 2020 |
| Easymove of Swindon Limited | Transport & logistics | 2000 |