| Earls Barton Residents Management Company Limited | Households | 2017 |
| Early Readers, Growing Minds Limited | Education | 2024 |
| East Midlands Geotech Limited | Construction | 2015 |
| Eastern Eagle Transport Ltd | Wholesale & retail | 2011 |
| Easy DIY Doors Ltd | Manufacturing | 2025 |
| Easy Weigh Limited | Professional & scientific | 2013 |
| Eaton Transport Ltd | Transport & logistics | 2016 |
| EBL Electrical Limited | Construction | 2019 |
| Eclipse 2020 Ltd | Administrative & support | 2019 |
| Eclipse Automotive Technology Limited | Wholesale & retail | 2004 |
| Eclipse Diagnostics EOT Limited | Professional & scientific | 2020 |
| Eclipse Diagnostics Group Limited | Wholesale & retail | 2020 |
| Eclipse Diagnostics Ltd | Extraterritorial | 2007 |
| Eco Appliance Solutions Ltd | Wholesale & retail | 2025 |
| Eco Cleaning Specialist Limited | Construction | 2018 |
| Eco Collections and Redistribution CIC | Wholesale & retail | 2024 |
| Eco Skip Hire Limited | Water & waste | 1998 |
| Ecomfort Properties Limited | Real estate | 2022 |
| Ecomm 2022 Limited | Wholesale & retail | 2022 |
| Edenstar UK Ltd | Wholesale & retail | 2002 |
| Edgewood Management Company NO 1 Limited | Households | 2010 |
| Edify EV Ltd | Professional & scientific | 2001 |
| Edis R Ltd | Transport & logistics | 2024 |
| Edmonds Auto Refinishing Limited | Wholesale & retail | 2018 |
| Edwards Bros Property Limited | Real estate | 2024 |
| Edwards Stays UK Ltd | Real estate | 2024 |
| Edygo Ltd | Transport & logistics | 2019 |
| EG (Training) Limited | Education | 2003 |
| Ejoj Ltd | Wholesale & retail | 2023 |
| Elan Active Limited | Arts & recreation | 2013 |
| Electrofitz Limited | Construction | 2021 |
| Elegant Aesthetics by JM Limited | Other services | 2024 |
| Elegant Shades UK Ltd | Other services | 2025 |
| Elevate Community Football Club Limited | Education | 2025 |
| Elevationx Limited | Education | 2023 |
| Elex Property Limited | Real estate | 2025 |
| Elink Systems Limited | Extraterritorial | 2012 |
| Elite BID Solutions Limited | Professional & scientific | 2024 |
| Elite Protection Solutions Ltd | Administrative & support | 2025 |
| Ellepleasure Ltd | Wholesale & retail | 2024 |
| Elliker, Dayton, Gilbert & Orton Ltd | Wholesale & retail | 2024 |
| Elliot Spencer Holdings Limited | Financial services | 2015 |
| Elliott Electrical Services Limited | Manufacturing | 1998 |
| Elliott Homer Hair Limited | Other services | 2020 |
| Elliott Maintenance Ltd | Construction | 2017 |
| Ellise Gifts & Design Ltd | Wholesale & retail | 2025 |
| ELM Gardens (Stone) Management Company Limited | Households | 2016 |
| Elms Electrical Solutions Ltd | Construction | 2024 |
| Eloise Developments Limited | Construction | 2025 |
| ELY James Ltd | Administrative & support | 2025 |
| EM Book-Keeping Services Ltd | Professional & scientific | 2011 |
| Emerald Dental Laboratory Ltd | Health & social care | 2011 |
| Emerald Engineering Services Ltd | Construction | 2023 |
| Emily Jane Limited | Wholesale & retail | 2025 |
| EMP Cleaning Services Ltd | Administrative & support | 2018 |
| Empire Glazing Systems Limited | Manufacturing | 2022 |
| Empire Hairdressing Ltd | Other services | 2023 |
| Empire Kits Limited | Wholesale & retail | 2015 |
| Empress Gardens (Tiverton) Management Company Limited | Households | 2025 |
| Emsteele Ltd | Real estate | 2020 |
| ENA Care Call Limited | Health & social care | 1998 |
| Energyevolved Ltd | Construction | 2024 |
| Engineered Power & Control Solutions Ltd | Professional & scientific | 2016 |
| Engineered Solutions Ltd | Manufacturing | 2016 |
| Engineered Training Services Limited | Education | 2023 |
| Enhanced Protection Systems UK Limited | Wholesale & retail | 2003 |
| Enhanced Telecommunications Limited | Information & communication | 2014 |
| Ensco 1340 Limited | Mining & quarrying | 2019 |
| Enviroclean Limited | Extraterritorial | 2006 |
| Environmental Special Operations Service Limited | Professional & scientific | 2003 |
| EPM Admin Limited | Information & communication | 2012 |
| Equal Support Opportunities CIC | Arts & recreation | 2016 |
| ERA Corporate Services Limited | Other services | 2020 |
| ERA Solutions Limited | Information & communication | 2013 |
| Erodetech Limited | Manufacturing | 2020 |
| Ervis Automotive Ltd | Wholesale & retail | 2026 |
| Escape and Explore Ltd | Administrative & support | 2025 |
| Essential Laptop Repairs Limited | Manufacturing | 2009 |
| Ethics and Antics Limited | Wholesale & retail | 2016 |
| Ethos Matrix Ltd | Professional & scientific | 2022 |
| Europeople Limited | Administrative & support | 2002 |
| Evacusafe (UK) Limited | Professional & scientific | 2005 |
| Evacustair Limited | Transport & logistics | 2017 |
| Event Floorplans Ltd | Professional & scientific | 2003 |
| Evolve BUS & Coach Ltd. | Transport & logistics | 2009 |
| Ewok Engineering Ltd | Construction | 2025 |
| EX Scintilla Limited | Administrative & support | 2013 |
| Excel Music Schools Limited | Education | 2003 |
| Excel Property (Derbyshire) Ltd | Real estate | 2021 |
| Exev Services Limited | Other services | 2005 |
| Expert Glass & Glazing Limited | Construction | 1999 |
| Express Ironing & Cleaning Services Ltd | Other services | 2017 |
| Express Options Limited | Transport & logistics | 2024 |
| Exsim Ltd | Arts & recreation | 2011 |
| Exterius Facilities Management Ltd | Administrative & support | 2010 |
| External Property Solutions Limited | Construction | 2010 |
| F T Recruit Midlands Limited | Administrative & support | 2019 |
| Factory Yard Limited | Wholesale & retail | 2023 |
| Fairlane MOT Hub Ltd | Wholesale & retail | 2026 |
| Fairways Branston Management (NO 1) Limited | Households | 1993 |