| SLS Global Solutions Limited | Professional & scientific | 2019 |
| Smart Bakset Ltd | Wholesale & retail | 2026 |
| Smartroof Holdings Limited | Financial services | 2019 |
| Smartroof Limited | Manufacturing | 2012 |
| Smile Caravan and Motorhome Care Ltd | Manufacturing | 2026 |
| Smiths Logistics Ltd | Transport & logistics | 2009 |
| Smiths Transport (Woodville) Limited | Transport & logistics | 1966 |
| SMS Engineering Services Limited | Professional & scientific | 2002 |
| SMT High Voltage Ltd | Construction | 2019 |
| Snap Ding Web Design Limited | Information & communication | 2023 |
| Snowbek Property Limited | Real estate | 1985 |
| Socius Pharma Limited | Financial services | 2014 |
| SOD Property Care Ltd | Construction | 2026 |
| Soft Solutions Ltd | Wholesale & retail | 2019 |
| Softindex Limited | Information & communication | 2022 |
| Softindex-Competitions Limited | Arts & recreation | 2025 |
| Softleys Limited | Hospitality | 2003 |
| Soitu Trans Ltd | Transport & logistics | 2019 |
| Solar Smart Solutions Ltd | Construction | 2025 |
| Solarshine (UK) Ltd | Wholesale & retail | 2016 |
| Solid Gold Consulting Ltd | Wholesale & retail | 2008 |
| Solution Automation Ltd | Information & communication | 2020 |
| Sonic Boom Music CIC | Arts & recreation | 2024 |
| Sorega Ltd | Construction | 2024 |
| Soul Sense Interactive Ltd | Information & communication | 2021 |
| Soulv Limited | Manufacturing | 2025 |
| Soundlightinguk Limited | Arts & recreation | 2016 |
| Sounds (Wholesale) Limited | Administrative & support | 1991 |
| South Derbyshire Construction Limited | Construction | 2014 |
| South Derbyshire CVS | Other services | 2003 |
| South India 2 UK Ltd | Wholesale & retail | 2026 |
| Southview (Wrenthorpe) Management Company Limited | Households | 2016 |
| Sovereign Land (Witney) Limited | Construction | 2011 |
| Specialist Overseas Plant Hire Limited | Extraterritorial | 2012 |
| Specialist Rebar Supplies Limited | Manufacturing | 2016 |
| Specialist Tube Supplies Limited | Wholesale & retail | 2003 |
| Speed Delivery Ltd | Transport & logistics | 2015 |
| Sph-Avionics Limited | Manufacturing | 2007 |
| Spirational Steps Limited | Health & social care | 2015 |
| Splashtastic Ltd | Education | 2014 |
| Splish Splash Swim Ltd | Arts & recreation | 2012 |
| Spooky-Nook Creative Limited | Manufacturing | 2003 |
| Spot IT Cleaning Services Ltd | Administrative & support | 2025 |
| SPP Training and Recruitment Ltd | Administrative & support | 2020 |
| SPP Twfl Ltd | Transport & logistics | 2022 |
| Sprayaway Exterior Cleaning Limited | Administrative & support | 2024 |
| Spring Thinking (Central) Limited | Professional & scientific | 2007 |
| Springfields Phoenix Limited | Financial services | 2024 |
| Springfields Rise Limited | Real estate | 2024 |
| Springfields Twogen Limited | Financial services | 2024 |
| SPT Groundworks & Building Ltd | Construction | 2022 |
| SPW Consultancy Ltd | Professional & scientific | 2014 |
| SRS Carpentry & Joinery Limited | Construction | 2016 |
| SRS Local Express UK Ltd | Wholesale & retail | 2025 |
| SSR Sam's Servicing and Repairs Ltd | Wholesale & retail | 2024 |
| ST Neots Mansions Management Limited | Households | 2012 |
| ST. James Place (Norton Canes) Management Company Limited | Households | 2005 |
| Stacey Quinzi Ltd | Extraterritorial | 2024 |
| Staffordshire Vehicle Solutions Ltd | Administrative & support | 2023 |
| Stamps & Woods Ltd | Hospitality | 2026 |
| Standish (Bloor Homes) Management Company Limited | Households | 2017 |
| Standout Marketing Limited | Professional & scientific | 2026 |
| Stanleigh House RTM Company Limited | Households | 2008 |
| Steadfast Resource Developments Limited | Wholesale & retail | 2009 |
| Steam Mill Lodges Ltd | Hospitality | 2020 |
| Stencil Gardens (Aldridge) Management Company Limited | Households | 2020 |
| Stenson Shooting Club Limited | Extraterritorial | 2002 |
| Steph's Hair and Beauty Salon Limited | Other services | 2023 |
| Stephens Sports Ltd | Arts & recreation | 2026 |
| Steve Cook Solutions Ltd | Professional & scientific | 2019 |
| Steve Tilley Motor Repairs Limited | Extraterritorial | 2013 |
| Stickeaze Ltd | Manufacturing | 2023 |
| Stone Direct (International) Limited | Construction | 2016 |
| Stone Edge Consulting Ltd | Professional & scientific | 2025 |
| Stran Limited | Administrative & support | 2016 |
| Strands Care Ltd | Health & social care | 2025 |
| Stratum Core Consulting Ltd | Professional & scientific | 2022 |
| Streamline Safety & Medical Solutions Ltd | Administrative & support | 2026 |
| STT Services 247 Ltd | Wholesale & retail | 2023 |
| Studio Bear Ltd | Manufacturing | 2022 |
| Stuki’S Ltd | Professional & scientific | 2025 |
| Subtle Software Limited | Information & communication | 2016 |
| Subzero Group Ltd | Professional & scientific | 2024 |
| Sudale Search & Select Limited | Administrative & support | 2021 |
| Suds & Strolls Ltd | Other services | 2024 |
| Sue's Dog Walking and Pet Care Ltd. | Other services | 2022 |
| Sugarninja Ltd | Professional & scientific | 2026 |
| Summerfield Mortgages Ltd | Financial services | 2025 |
| Summerland Lane Management Company Limited | Households | 2018 |
| Summers Investment Properties Ltd | Real estate | 2026 |
| Summit Automation Ltd | Professional & scientific | 2021 |
| Sundae & Co Wellness Ltd | Hospitality | 2025 |
| Sunnyside Pet Cremation Services Ltd | Water & waste | 2022 |
| Sunrise Auditing Solutions Limited | Information & communication | 2014 |
| Supaglazing Online Ltd | Manufacturing | 2021 |
| Super Audio Brains Ltd | Information & communication | 2014 |
| Surefix (Midlands) Ltd | Real estate | 2017 |
| Surplus Limited | Wholesale & retail | 2025 |
| Sutherland View Management Company Limited | Households | 2008 |
| SW Engineering Services Limited | Construction | 2014 |