| S. Bailey Installations Limited | Professional & scientific | 2003 |
| S.A Vehicle Solutions Ltd | Transport & logistics | 2015 |
| S.C.S. Aquatic & Pet Wholesale Limited | Wholesale & retail | 2005 |
| S.N.Jones Plumbing & Heating Ltd | Construction | 2021 |
| S.V.D.J Consultancy Limited | Professional & scientific | 2025 |
| Sabine Brothers (Engineering) Limited | Manufacturing | 1916 |
| Sabine Brothers (Foundry) Limited | Manufacturing | 2014 |
| Sabine Brothers Limited | Professional & scientific | 2014 |
| Sacrestia 4 Properties Limited | Real estate | 2024 |
| Saddington's Yard Ltd | Real estate | 2025 |
| Safe Scaffolding Midlands Limited | Administrative & support | 2002 |
| Saffron Celebration of Life Limited | Hospitality | 2025 |
| Saffron Event & Venue Caterers Limited | Hospitality | 2011 |
| Saffron Sandwich Vans Limited | Hospitality | 2022 |
| Sagc Developments Limited | Real estate | 2001 |
| Sage Site Services Limited | Professional & scientific | 2016 |
| Sahib Fish and Chips Limited | Hospitality | 2024 |
| Salisbury Gardens Management Company Limited | Households | 2007 |
| Salon NO10 Limited | Other services | 2023 |
| Salters Park Residents Management Company Limited | Households | 2014 |
| Salute Property Ltd | Hospitality | 2025 |
| SAM Shaw Process Limited | Manufacturing | 2017 |
| Samantha Jones Professional Singer Ltd | Arts & recreation | 2024 |
| Sameday UK (Midlands) Limited | Transport & logistics | 2018 |
| Sams Automobile Transport Ltd | Transport & logistics | 2026 |
| Sams Furniture for YOU Ltd | Wholesale & retail | 2021 |
| Sandbrook (Streethay) Management Company Limited | Households | 2025 |
| SAO Consulting Ltd | Information & communication | 2014 |
| Sapphire Vehicle Services Limited | Wholesale & retail | 2010 |
| Sarah Burgess Limited | Other services | 2018 |
| Sarwan Transport Ltd | Transport & logistics | 2022 |
| Saxon Brook Management Company Limited | Households | 2019 |
| Saxon Woods (Flitwick) Management Company Limited | Households | 2026 |
| SBP Fencing Ltd | Administrative & support | 2024 |
| SBP Landscapes & Property Ltd | Administrative & support | 2024 |
| SC Occupational Therapy Ltd | Health & social care | 2026 |
| Scarlet Pimpernel (Harborne) Management Company Limited | Households | 2014 |
| Scarlett Property Management Services Ltd | Real estate | 2025 |
| Scarlett Ridge Homes Ltd | Construction | 2019 |
| Scholar's Green (Northampton) Residents Management Company Limited | Households | 2019 |
| School of Street Ltd | Arts & recreation | 2013 |
| Scion Engineering Limited | Manufacturing | 2018 |
| Scotts Transport Ltd | Transport & logistics | 2025 |
| SCV Transport Limited | Transport & logistics | 2025 |
| SDI Couriers Ltd | Transport & logistics | 2020 |
| Seaking Fish Bar Limited | Hospitality | 2025 |
| Secret CON Ltd | Administrative & support | 2021 |
| Secure & Profitable Growth Limited | Professional & scientific | 2014 |
| Secure Carpentry & Renovation Ltd | Construction | 2019 |
| Secure Living & Developments Ltd | Real estate | 2025 |
| Secured Property Ltd | Information & communication | 2023 |
| Sedgwick Igoe & Associates Ltd. | Professional & scientific | 2002 |
| Sense Subsea Ltd | Professional & scientific | 2019 |
| Sentience Sensory Spaces CIC | Health & social care | 2025 |
| Sentinel Strategy Limited | Professional & scientific | 2016 |
| Sentinel Window Films Ltd | Other services | 2023 |
| Servu Online Limited | Information & communication | 2019 |
| SET J Properties Ltd | Real estate | 2026 |
| Severn Meadows (Upton on Severn) Management Company Limited | Households | 2025 |
| SEW Essential Ltd | Wholesale & retail | 1999 |
| SG Design Studio Limited | Construction | 2005 |
| SG Electrical Contractors Limited | Construction | 2021 |
| SG Storage Solutions Ltd | Transport & logistics | 2019 |
| SH Consulting Organisation Limited | Professional & scientific | 2025 |
| Shadow DEV UK Ltd | Information & communication | 2024 |
| Sharpe Brothers & Co.Limited | Real estate | 1939 |
| Sharpe's Pottery Heritage and Arts Trust Limited | Arts & recreation | 1999 |
| Sharpswood Ltd | Wholesale & retail | 2025 |
| Shawbury Limited | Manufacturing | 1985 |
| Shears Engineering Services Ltd | Wholesale & retail | 2026 |
| Shelby (Midlands) Ltd | Professional & scientific | 2018 |
| Shelby Construction (Midlands) Ltd | Construction | 2018 |
| Shenfield Communications Ltd | Wholesale & retail | 2012 |
| Shenton Property Investments Ltd | Real estate | 2020 |
| Shewashok Ltd | Other services | 2024 |
| Shillington Online Education Limited | Education | 2023 |
| Shilvocks Independent Funeral Directors Ltd | Other services | 2024 |
| Shimmer Products LLP | | 2021 |
| Shorthouse Holdings Limited | Financial services | 2022 |
| Showtime Events (UK) Limited | Arts & recreation | 2024 |
| Sidat Properties Limited | Real estate | 2023 |
| Siegwerk UK Limited | Manufacturing | 2004 |
| Sigma Controls Ltd | Information & communication | 2024 |
| Sign Intent Ltd | Manufacturing | 2020 |
| Silver Wolf Events Ltd | Administrative & support | 2018 |
| Silverlined Investments Limited | Real estate | 2005 |
| Simhah Limited | Information & communication | 2015 |
| Simon Smith Plant Repairs Limited | Manufacturing | 2017 |
| Simon&Kerryproperty Agents Ltd | Households | 2025 |
| Sistr Socials Ltd | Administrative & support | 2025 |
| SJ Enterprise Ltd | Information & communication | 2021 |
| SJM Logistics Limited | Transport & logistics | 2012 |
| SJS Facilities Ltd | Administrative & support | 2025 |
| SJV Engineering Ltd | Professional & scientific | 2022 |
| SK Go GAS Limited | Construction | 2024 |
| SK Hartshone Limited | Hospitality | 2026 |
| Skillflux Advisory Limited | Education | 2017 |
| Skruub Limited | Administrative & support | 2024 |
| SKW Engineering & Coatings Ltd | Manufacturing | 2026 |
| Skylevel Limited | Real estate | 2001 |