| Shez Invest Ltd | Real estate | 2023 |
| Shfire Ltd | Public administration | 2019 |
| Shield Traffic Management Limited | Construction | 2016 |
| Shimal Limited | Health & social care | 2016 |
| Shinner Properties Limited | Real estate | 2025 |
| Ship Air International Ltd | Transport & logistics | 2023 |
| Shipley Investments Limited | Financial services | 2008 |
| Shiraz Pizza Ltd | Administrative & support | 2017 |
| Shire Investments Limited | Construction | 1998 |
| Shirley's Wellbeing CIC | Health & social care | 2026 |
| Shirrell Heath Ltd | Hospitality | 2022 |
| Shiv Gift Shop Limited | Wholesale & retail | 2024 |
| Shiv Products Limited | Wholesale & retail | 2025 |
| Shivam PAW Ltd | Information & communication | 2023 |
| Shizzles & Giggles Ltd | Wholesale & retail | 2025 |
| SHJ Real Estates Limited | Real estate | 2026 |
| Shoesmith Properties Ltd | Real estate | 2022 |
| Shokar Haulage Limited | Transport & logistics | 2008 |
| Shopwired Experts Limited | Other services | 2020 |
| Shopwired Operations Limited | Other services | 2020 |
| Shopwired Payments Limited | Other services | 2018 |
| Shopwithjw Ltd | Manufacturing | 2022 |
| Shorizon Ltd | Construction | 2018 |
| Shortall Consulting Ltd | Professional & scientific | 2012 |
| Shroyas Ltd | Professional & scientific | 2016 |
| Shrubbery Consultancy Limited | Professional & scientific | 2025 |
| Shrubbery House Property Management Ltd | Real estate | 2024 |
| Shruhan Ltd | Health & social care | 2021 |
| Shruhan Property Ltd | Real estate | 2023 |
| Shua Holdings Limited | Real estate | 2015 |
| Shua Housing Ltd | Real estate | 2018 |
| Shua Properties (Cornwall) Limited | Real estate | 2019 |
| Shukokai Karate Sutton Coldfield Limited | Arts & recreation | 2025 |
| Shuncle Ltd | Transport & logistics | 2023 |
| Shyam Group Ltd | Wholesale & retail | 2016 |
| Sian Collister Ltd | Administrative & support | 2011 |
| Siddhi Limited | Wholesale & retail | 2023 |
| Sidhu Homes (UK) Limited | Real estate | 2021 |
| Sidhu Homes Group Ltd | Construction | 2025 |
| Sidinflow Service Limited | Information & communication | 2025 |
| Sidley Piper Homes (Bagnall's Lock) Ltd | Construction | 2018 |
| Sidley Piper Homes (Beaconsfield House) Ltd | Construction | 2018 |
| Sidley Piper Homes (Home Farm) Limited | Construction | 2020 |
| Sidley Piper Homes (Mill House) Limited | Construction | 2021 |
| Sidley Piper Homes (Pemberton ST) Ltd | Construction | 2017 |
| Sidley Piper Limited | Administrative & support | 2014 |
| Siella Legacy Holdings Ltd | Financial services | 2025 |
| Siella Trading Co. Ltd | Financial services | 2025 |
| Sigmacity Group Limited | Information & communication | 2020 |
| Sigmacity Limited | Information & communication | 2005 |
| Signal That Matters Limited | Professional & scientific | 2025 |
| Signature Alloy Wheel Refurbishment Ltd | Wholesale & retail | 2022 |
| Signature Apparel Limited | Wholesale & retail | 2012 |
| Signature Holdings Limited | Real estate | 2002 |
| Signature Holdings Property Group Ltd | Real estate | 2019 |
| Signature Investments & Realty Ltd | Real estate | 2024 |
| Signature Notes Ltd | Wholesale & retail | 2026 |
| Signtec (UK) Limited | Manufacturing | 2013 |
| SIID1974 Ltd | Health & social care | 2022 |
| Sikandarpur Ltd | Households | 2024 |
| Sikh Temples Kabaddi Club Birmingham Ltd | Arts & recreation | 2018 |
| Silimpur Limited | Hospitality | 2026 |
| Silk & Stone Ltd | Manufacturing | 2025 |
| Silver Bear Property Holdings Limited | Real estate | 2017 |
| Silver Birch Care Home Ltd | Health & social care | 2018 |
| Silver Birch Motor Company Ltd | Extraterritorial | 2016 |
| Silver Lady Funeral Service Limited | Extraterritorial | 1996 |
| Silver Tree Bakery Limited | Manufacturing | 2019 |
| Silverback Security Group Ltd | Administrative & support | 2020 |
| Silveroak Lettings Limited | Real estate | 2025 |
| Simco Projects Limited | Real estate | 2016 |
| Simco Rentals Limited | Real estate | 2019 |
| Simkins & Woodward Electrical Limited | Construction | 2009 |
| Simmb Limited | Public administration | 2021 |
| Simmons & Weber Engineering Limited | Professional & scientific | 2025 |
| Simon Hartley Flow Control Limited | Manufacturing | 2018 |
| Simon John Hair Limited | Other services | 1998 |
| Simon Johnstone Carpets Ltd. | Wholesale & retail | 2002 |
| Simon Kirkland Enterprises Limited | Education | 2026 |
| Simon Mann Consulting Limited | Professional & scientific | 2015 |
| Simon Oakes Limited | Professional & scientific | 2025 |
| Simon Roberts Illustration Limited | Arts & recreation | 2003 |
| Simple Medical Solutions Limited | Administrative & support | 2010 |
| Simplicity by Design Ltd | Wholesale & retail | 2008 |
| Simplicity Funerals Limited | Extraterritorial | 1942 |
| Simply Mattresses Ltd | Wholesale & retail | 2025 |
| Simply Megan Limited | Other services | 2025 |
| Simply Personal Finance Limited | Professional & scientific | 2017 |
| Simply School Supplies C.I.C. | Wholesale & retail | 2025 |
| Simply-Greek Limited | Hospitality | 2024 |
| Simpson's GIN Palace Limited | Hospitality | 2016 |
| Simpsons (Undertakers Requisites) Limited | Extraterritorial | 1932 |
| Sims Consult & Trading Ltd | Construction | 2019 |
| Sing Play Connect CIC | Education | 2020 |
| Singh Actuarial Services Ltd | Financial services | 2024 |
| Singh Property Solutions Limited | Real estate | 2024 |
| Single Town Ltd | Information & communication | 2024 |
| Singleton Manor Holiday Lettings Limited | Hospitality | 2020 |
| Siphoncharm Ltd | Administrative & support | 2019 |
| SIR Winston Limited | Hospitality | 2018 |