| Selim Smith & Co. Limited | Extraterritorial | 1964 |
| Sellcell (USA) Limited | Information & communication | 2016 |
| Selli Holding Ltd | Financial services | 2019 |
| Sellman Holdings 2 Limited | Financial services | 2020 |
| Sellman Properties Newman RD Ltd | Real estate | 2014 |
| Sematics Capital Limited | Real estate | 2020 |
| Sematics Company Holdings Limited | Financial services | 2020 |
| Sematics Limited | Information & communication | 2019 |
| SEN Central Limited | Administrative & support | 2016 |
| Senate Home Ltd | Administrative & support | 2017 |
| Senior Vehicle Rental Limited | Administrative & support | 2001 |
| Senn Group Holdings Ltd | Wholesale & retail | 2026 |
| Sensible Investing TV Limited | Extraterritorial | 2014 |
| Sensory Smart Ltd | Wholesale & retail | 2023 |
| Sentry PM Solutions Ltd | Professional & scientific | 2025 |
| SEO IT Right Ltd | Information & communication | 2010 |
| Sequel Events Ltd | Arts & recreation | 2022 |
| Sercom Global Ltd | Wholesale & retail | 2026 |
| Serene and Serena Holdings Ltd | Real estate | 2024 |
| Serenity Bar & Cafe Ltd | Hospitality | 2024 |
| Serenity Limited | Extraterritorial | 1983 |
| Serious Deals UK Ltd | Information & communication | 2021 |
| Serpentine Birmingham Ltd | Hospitality | 2022 |
| Serviceincluded Limited | Professional & scientific | 2000 |
| Servitech Solutions Ltd | Information & communication | 2025 |
| Sessile Interim Management Solutions Limited | Professional & scientific | 2018 |
| Settlement Solutions Limited | Other services | 2018 |
| Sevaari Ltd | Wholesale & retail | 2024 |
| Seven Wishes Limited | Real estate | 2023 |
| Sevenoaks District Crematorium Limited | Other services | 2017 |
| Severe Injury Solicitors Limited | Professional & scientific | 2023 |
| Severn Fryers Limited | Hospitality | 2025 |
| Severn Valley Investments Limited | Other services | 2018 |
| SF Mellor Ltd | Transport & logistics | 2022 |
| SFS Counselling and Psychotherapy Ltd | Health & social care | 2025 |
| SG Aesthetic & Laser Clinic Ltd | Other services | 2021 |
| SG AEV Ltd | Wholesale & retail | 2018 |
| SG Hair Limited | Other services | 2017 |
| SGB Contracting Limited | Construction | 2022 |
| SGD Broadcast Media Limited | Information & communication | 2004 |
| Sgglpi Limited | Financial services | 2021 |
| SGH Property Limited | Real estate | 2020 |
| SGT Transport Ltd | Transport & logistics | 2021 |
| SH Clinical Practice Limited | Health & social care | 2025 |
| SH GAS & Plumbing Limited | Construction | 2022 |
| SH Wholesale Ltd | Wholesale & retail | 2025 |
| SHA Sutton Coldfield CIC | Other services | 2022 |
| Shacklefords Limited | Professional & scientific | 2003 |
| Shadow Stance Media Limited | Information & communication | 2014 |
| Shahban Properties Ltd | Real estate | 2025 |
| Shake Enterprise Ltd | Wholesale & retail | 2024 |
| Shakehouse Sutton Coldfield Ltd | Wholesale & retail | 2024 |
| Shakespeare Care Limited | Health & social care | 2018 |
| Shakthi Medical Ltd | Health & social care | 2014 |
| Shaku Medical Ltd | Health & social care | 2013 |
| Shamauk Ltd | Wholesale & retail | 2022 |
| Shamrock Real Estate Limited | Real estate | 2025 |
| Shamrock Trading Ltd | Wholesale & retail | 2024 |
| Shams Engineering Limited | Professional & scientific | 2025 |
| Shape a Life Limited | Administrative & support | 2023 |
| Shaped Group Ltd | Manufacturing | 2025 |
| Shapers (West Midlands) Limited | Other services | 2017 |
| Shapers Aesthetics Training Limited | Health & social care | 2015 |
| Shar Design Ltd | Professional & scientific | 2026 |
| Sharan Property Ltd | Real estate | 2023 |
| Shared Success Solutions Limited | Professional & scientific | 2011 |
| Sharepoint City Limited | Professional & scientific | 2009 |
| Shareway Limited | Financial services | 1992 |
| Sharif & TAZ Holdings Ltd | Financial services | 2025 |
| Sharif Brothers Ltd | Wholesale & retail | 2017 |
| Shark Tank Properties Limited | Hospitality | 2023 |
| Sharma Healthcare Solutions Ltd | Health & social care | 2026 |
| Sharp Things Limited | Information & communication | 2019 |
| Shave and More Limited | Other services | 2024 |
| Shaw & Partners Limited | Manufacturing | 2016 |
| Shawley Properties 100 Limited | Real estate | 2026 |
| Shawley Properties Group Limited | Real estate | 2026 |
| Shays Wholesalers Limited | Wholesale & retail | 2024 |
| SHB Nova Group Ltd | Financial services | 2026 |
| SHEBEASTS01 C.I.C. | Hospitality | 2018 |
| Shedean Ltd | Wholesale & retail | 2020 |
| Sheep Music Ltd | Arts & recreation | 2002 |
| Sheer Force Solutions Ltd | Information & communication | 2019 |
| Sheer Products Limited | Wholesale & retail | 2020 |
| Sheer Properties Ltd | Real estate | 2020 |
| Sheffield Sheds Limited | Manufacturing | 2010 |
| Shelco Holdings Limited | Financial services | 2024 |
| Shellia Consulting Limited | Information & communication | 2015 |
| Shelsley Property and Investments Limited | Real estate | 2018 |
| Shemlan Group Limited | Financial services | 2019 |
| Shensmith Group Limited | Wholesale & retail | 2009 |
| Shensmith Law Limited | Professional & scientific | 2017 |
| Shenstone Consultants Limited | Professional & scientific | 2019 |
| Shepherd's Consultancy Limited | Professional & scientific | 2000 |
| Shergate Limited | Construction | 1996 |
| Sheridan Finance Ltd | Professional & scientific | 2008 |
| Sherifoot Limited | Real estate | 2006 |
| Sherwood 6 Limited | Extraterritorial | 1984 |
| Sherwood Hathaway Limited | Extraterritorial | 2007 |
| Shez & Ahmad Ltd | Wholesale & retail | 2025 |