| E Gildea Contractors Limited | Construction | 2012 |
| E Hurton & SON Limited | Extraterritorial | 2000 |
| E Loc@Tions Ltd | Professional & scientific | 2010 |
| E&Dem Foods Ltd | Wholesale & retail | 2019 |
| E&J Heating and Electric Contractors Ltd | Construction | 2019 |
| E&Rv Ltd | Real estate | 2019 |
| E-Care 247 UK Ltd | Administrative & support | 2026 |
| E-Ct Group Ltd | Financial services | 2026 |
| E-Fervour Limited | Other services | 2001 |
| E-Learn 247 UK Ltd | Administrative & support | 2026 |
| E-Or Limited | Administrative & support | 2016 |
| E-Protego Ltd | Information & communication | 2021 |
| E. Brigham Funeral Directors Limited | Extraterritorial | 1985 |
| E. Finch and Sons Limited | Extraterritorial | 1925 |
| E. S. & H. Limited | Administrative & support | 2002 |
| E.A. Fenwick & Co. Limited | Professional & scientific | 2010 |
| E.C.L Business Services Limited | Financial services | 2023 |
| E.Dunderdale Syner & Co.Limited | Health & social care | 1967 |
| E.F.Edwards Limited | Extraterritorial | 1916 |
| E.M.Lander,Limited | Extraterritorial | 1916 |
| E.M.S. West Midlands Limited | Construction | 1999 |
| E.Ngage Training & Consultancy Limited | Real estate | 2014 |
| E.Seymour & SON Limited | Extraterritorial | 1935 |
| EA Property Lettings Limited | Real estate | 2025 |
| Eagle Consortium Limited | Professional & scientific | 2012 |
| Eagle Sports Gear Ltd | Wholesale & retail | 2010 |
| Eagles Homecare UK CIC | Other services | 2024 |
| Eagles Nest Properties Limited | Real estate | 2022 |
| Eaglesfield AI Ltd | Information & communication | 2025 |
| Eaglesmedia Ltd | Manufacturing | 2020 |
| EAH Property Limited | Real estate | 2020 |
| EAR Relief Ltd | Health & social care | 2025 |
| Earl of Plymouth Limited | Extraterritorial | 1989 |
| Early Active Limited | Extraterritorial | 2009 |
| Early Doors Public House Ltd | Hospitality | 2024 |
| Earwaxspecialist.Co.Uk Ltd | Wholesale & retail | 2018 |
| Ease AI Ltd. | Information & communication | 2022 |
| Easeai Agents Ltd. | Information & communication | 2025 |
| East 5TH Limited | Information & communication | 2015 |
| East Clune Care Home Limited | Real estate | 2024 |
| East Dunley Cottages Limited | Hospitality | 2017 |
| East Midlands ICC Ltd | Other services | 2023 |
| East Midlands Recruitment Ltd | Administrative & support | 2020 |
| Eastern Airways (Europe) Limited | Transport & logistics | 1998 |
| Eastern Airways International Limited | Financial services | 2000 |
| Eastern Shipping Ltd | Transport & logistics | 2014 |
| Easternhill Estates Ltd | Real estate | 2006 |
| Eastgate Estates Limited | Real estate | 2022 |
| Eastgate Home Improvements Limited | Administrative & support | 2008 |
| Eastmid Alliance Care Ltd | Health & social care | 2024 |
| Eastside Inns Limited | Hospitality | 2018 |
| Easy Fashion Limited | Wholesale & retail | 2006 |
| Easy Find Recruitment Limited | Administrative & support | 2019 |
| Eatclub Technologies Ltd | Information & communication | 2025 |
| Eaton Accountants Ltd | Professional & scientific | 2010 |
| Eazy Purchaze Ltd | Extraterritorial | 2015 |
| EB Civil Engineering Limited | Construction | 2019 |
| Ebony-Roxanne Belle Limited | Extraterritorial | 2025 |
| Eboot Limited | Wholesale & retail | 2023 |
| Eboxt Limited | Construction | 2025 |
| Ebrook Fitness Limited | Arts & recreation | 2021 |
| Ebrook Osteopathy Limited | Health & social care | 2017 |
| EC Contracts Limited | Professional & scientific | 2004 |
| Ecartuk Ltd | Information & communication | 2022 |
| Ecats Limited | Arts & recreation | 1998 |
| Eccleshall Pharmacy Limited | Wholesale & retail | 2000 |
| ECE Real Estate Limited | Real estate | 2023 |
| Echobliss Sound Therapy Limited | Health & social care | 2025 |
| Eclipse Corporate Advisory Limited | Professional & scientific | 2023 |
| Eclix Ltd | Wholesale & retail | 2025 |
| Eco FOX Agencies Limited | Wholesale & retail | 2020 |
| Eco Made Simple Forever Limited | Construction | 2017 |
| ECO100 Limited | Professional & scientific | 2024 |
| Ecoclip Limited | Manufacturing | 2021 |
| Ecogrow Community Interest Company | Hospitality | 2020 |
| Ecohydra Technologies Limited | Manufacturing | 2004 |
| Ecom Property Management Limited | Administrative & support | 2010 |
| Ecomera Ltd | Wholesale & retail | 2026 |
| Ecommerce Pro Ltd | Wholesale & retail | 2025 |
| Ecosalt Limited | Extraterritorial | 2024 |
| Ecotex Cleaning Systems Limited | Manufacturing | 2010 |
| Ecowire Limited | Construction | 2019 |
| Ecphair Ltd | Other services | 2022 |
| Ecrs Ventilation Ltd | Administrative & support | 2023 |
| Ecurie Sportive Ltd. | Real estate | 1995 |
| ED James Media Ltd | Arts & recreation | 2021 |
| EDA Performance Limited | Arts & recreation | 2026 |
| EDC Dept Limited | Wholesale & retail | 2024 |
| Eden Park Estate Limited | Extraterritorial | 1929 |
| Eden Wood Limited | Construction | 2010 |
| Edenwell Limited | Hospitality | 2022 |
| Edgbaston Mews Management Company Limited | Households | 2010 |
| Edge Agility Ltd | Professional & scientific | 2019 |
| Edge Creative Ltd | Information & communication | 2004 |
| Edge Hill Associates & Consultants Limited | Professional & scientific | 2025 |
| Edge Hill Associates Limited | Real estate | 2016 |
| Edges & Hedges Garden Maintenance Ltd | Administrative & support | 2013 |
| Edgington Enterprises Limited | Hospitality | 2003 |
| EDM Specialists (Darren Venables) Limited | Manufacturing | 2014 |
| Edmund & Lewis Limited | Extraterritorial | 1985 |