| Desi & Sergey Ltd | Hospitality | 2019 |
| Design Direction Limited | Construction | 1998 |
| Designture Creative Studio Limited | Arts & recreation | 2019 |
| Dessertify Ltd | Wholesale & retail | 2022 |
| Desserts Delivered Sunderland UK Limited | Hospitality | 2016 |
| Deus Fight Wear Ltd | Wholesale & retail | 2024 |
| Devachan Ltd | Manufacturing | 2021 |
| Devcap Properties Ltd | Real estate | 2022 |
| Devdroids Limited | Information & communication | 2026 |
| Develop IT Solutions Ltd | Information & communication | 2011 |
| Developkerr Ltd | Information & communication | 2019 |
| Devify Ltd | Information & communication | 2023 |
| Dewan KK Ltd | Wholesale & retail | 2026 |
| Dexter's ANP Locum Ltd | Health & social care | 2023 |
| Deyem Realty Properties Ltd | Real estate | 2024 |
| DG Commercial Group Ltd | Real estate | 2026 |
| DH Inspection Services (NE) Limited | Manufacturing | 2015 |
| Dhaliwal Transport National Ltd | Transport & logistics | 2014 |
| DHARANI9 Ltd | Hospitality | 2025 |
| DHE Garden Products Ltd | Manufacturing | 2020 |
| Dhiya Premier Ltd | Wholesale & retail | 2024 |
| Dialogue Fosters CIC | Education | 2021 |
| Diamond Hall Infant Academy | Education | 2013 |
| Diamond Vault Horizon Limited | Wholesale & retail | 2025 |
| Dickman Group LLP | | 2026 |
| Dickman Holdings Ltd | Financial services | 2025 |
| Dickman Property Ltd | Administrative & support | 2023 |
| Dicksommie Enterprises Limited | Health & social care | 2025 |
| Didiwash Limited | Administrative & support | 2025 |
| Diego's Joint CIC | Hospitality | 2024 |
| Diesel Tuning UK Limited | Wholesale & retail | 2005 |
| Diespeker Ceilings (Midlands) Limited | Professional & scientific | 1981 |
| Digi Digital Limited | Wholesale & retail | 2018 |
| Digi Next Solutions Ltd | Professional & scientific | 2024 |
| Digichem Ltd | Information & communication | 2013 |
| Digital Color Labs Limited | Other services | 2005 |
| Digital Industrial Innovation Ltd | Information & communication | 2019 |
| Digital Merch Depot Ltd | Information & communication | 2023 |
| Digital Signs NE Ltd | Construction | 2025 |
| Digitaltwin-Dynamics Ltd | Professional & scientific | 2025 |
| Digiwrap Signs Ltd | Manufacturing | 2026 |
| Dignity@Home Ltd | Health & social care | 2025 |
| Digon Property Services Ltd | Construction | 2014 |
| DIL Cutz Ltd | Other services | 2025 |
| Dimension Sundecks Limited | Construction | 2012 |
| Dinoram Leisure Ltd | Real estate | 2021 |
| Dioshe Multi Ltd | Wholesale & retail | 2026 |
| Direct Fitness UK Limited | Education | 2016 |
| Direct Funerals Limited | Other services | 1998 |
| Direct Property Partners Limited | Real estate | 2021 |
| Direct Thrive CIC | Professional & scientific | 2025 |
| Discount BED Stores Ltd | Wholesale & retail | 2024 |
| Dishani Food Ltd | Wholesale & retail | 2025 |
| Diva Holdings Limited | Real estate | 2021 |
| Diverse Energy Limited | Mining & quarrying | 2017 |
| Divine Hope Health Care Ltd | Health & social care | 2022 |
| Divine Sunderland Ltd | Hospitality | 2025 |
| Dixon Elite Developments Ltd | Construction | 2025 |
| Diya Sunderland Ltd | Hospitality | 2025 |
| Diyakos Ltd | Real estate | 2018 |
| DJ Cladding Ltd | Construction | 2023 |
| DJ Commissioning (NE) Limited | Professional & scientific | 2016 |
| DJ Electrical Sunderland Limited | Construction | 2016 |
| DJ Lowery Ltd | Other services | 2025 |
| DJ Roofing & Cladding (NE) Ltd | Construction | 2025 |
| DJ Surveying Ltd | Other services | 2017 |
| DJN Fabrications Limited | Manufacturing | 1995 |
| DJO Haulage Ltd | Transport & logistics | 2025 |
| DJP Surveying Services Ltd | Construction | 2022 |
| DJR Rigging and Lifting Limited | Construction | 2022 |
| DK Eco Solutions Ltd | Professional & scientific | 2024 |
| DKS Straightforward Ltd | Professional & scientific | 2015 |
| DLE Inspection Ltd | Manufacturing | 2024 |
| Dlec Management Services Limited | Professional & scientific | 2024 |
| DLF Utilities Ltd | Construction | 2021 |
| DLK NE Limited | Construction | 2022 |
| DLM Consultancy North East Limited | Professional & scientific | 2023 |
| DLM Property Ltd | Households | 2024 |
| DLP Property Ltd | Real estate | 2020 |
| DLR Drilling Ltd | Construction | 2018 |
| DLS Global Holdings Ltd | Financial services | 2026 |
| DLS Property Investment Ltd | Households | 2025 |
| DM 85 Limited | Health & social care | 2025 |
| DM Technical Sales Ltd | Professional & scientific | 2014 |
| DMA Estates Ltd | Real estate | 2003 |
| DMC Offshore (UK) Ltd | Administrative & support | 2009 |
| DMH Private Wealth Limited | Financial services | 2015 |
| DMJ Property North East Limited | Real estate | 2023 |
| DMP Renewable Consultancy Limited | Energy | 2018 |
| DMR Property Investments NE Limited | Real estate | 2025 |
| DMT Electrical Services Limited | Construction | 2015 |
| DN Accounting Services Ltd | Professional & scientific | 2021 |
| Dobbs Automation Ltd | Professional & scientific | 2021 |
| Dobson James Solutions Limited | Construction | 2011 |
| Dolled UP Training Ltd | Other services | 2022 |
| Domgm Ltd | Construction | 2018 |
| Domus Benassi Ltd | Real estate | 2025 |
| Donkins Limited | Hospitality | 2017 |
| Donsside Limited | Wholesale & retail | 2013 |
| Dontyne Systems Limited | Information & communication | 2006 |