| Danut Contractors Ltd | Administrative & support | 2025 |
| Dapper Cutz Ltd | Other services | 2025 |
| Darband Vape Ltd | Wholesale & retail | 2025 |
| Darceo Limited | Professional & scientific | 2026 |
| Dare North East Community Interest Company | Arts & recreation | 2013 |
| Dark Horse Fitness Ltd | Arts & recreation | 2021 |
| Darkstone Holdings Ltd | Professional & scientific | 2018 |
| Darmmey Courier & Logistics Limited | Transport & logistics | 2024 |
| Daro Investments Limited | Manufacturing | 2024 |
| Darren Jones Ltd | Health & social care | 2025 |
| Dartford Management Limited | Information & communication | 2016 |
| Dartford Manor Limited | Real estate | 2017 |
| Dartford Student Living Limited | Hospitality | 2014 |
| DAS Subsea Ltd | Other services | 2017 |
| Dataknead Ltd | Information & communication | 2019 |
| Datapro Northeast Ltd | Public administration | 2022 |
| Dave Cowan Surveys Limited | Professional & scientific | 2009 |
| Dave Young Building Services Ltd | Construction | 2019 |
| Davey MAL Ltd | Information & communication | 2019 |
| David Coates Contracting Ltd | Administrative & support | 2018 |
| David James Turner Construction Limited | Construction | 2002 |
| David MAW Limited | Construction | 2014 |
| Davik and Company Limited | Real estate | 2022 |
| Davison Partners Ltd | Administrative & support | 2013 |
| Davison Property Group Ltd | Real estate | 2025 |
| Davolimited Ltd | Health & social care | 2025 |
| Dazzling Divas Limited | Professional & scientific | 2020 |
| DB Cleaning Services NE Limited | Administrative & support | 2024 |
| DB Design & Engineering Ltd | Professional & scientific | 2022 |
| DB Logistics NE Limited | Information & communication | 2024 |
| Dbora Ltd | Real estate | 2025 |
| DC Property Management Services Ltd | Households | 2026 |
| DCB Engineering Services Ltd | Construction | 2025 |
| DCM Renewables Limited | Professional & scientific | 2024 |
| Dcmdr Ltd | Professional & scientific | 2025 |
| DCS Payroll (NE) Holdings Limited | Financial services | 2025 |
| DCS Payroll Agency (NE) Limited | Professional & scientific | 2002 |
| Ddac Properties Ltd | Real estate | 2025 |
| DE Giorgio's Village Pork Shops Limited | Wholesale & retail | 2014 |
| DE Niros Barber Shop Limited | Other services | 2005 |
| DE Risc Limited | Administrative & support | 2019 |
| DE Vivo Limited | Wholesale & retail | 2026 |
| De-Mira Solutions Ltd | Information & communication | 2024 |
| De-Revelation Group Limited | Information & communication | 2018 |
| Dead Dodo Publishing Limited | Information & communication | 2013 |
| Dead Good Community Interest Company | Education | 2023 |
| Dean Associates Properties Ltd | Real estate | 2016 |
| Dean Mould Limited | Agriculture & fishing | 2002 |
| Dean Stubbs Limited | Construction | 2012 |
| Debbiek Cakes and Events Ltd | Manufacturing | 2026 |
| Debby's Beauty Corner Ltd | Manufacturing | 2026 |
| DEC Enterprise Limited | Health & social care | 2020 |
| Decontamination Consultancy Services (DCS) Ltd | Administrative & support | 2026 |
| Decor Home Products Ltd | Wholesale & retail | 2015 |
| Dee-Blessed Ltd | Transport & logistics | 2025 |
| Deeflora Resources Ltd | Wholesale & retail | 2024 |
| Deep Clean Hand Carwash Ltd | Other services | 2026 |
| Deep Holdings SR1 Ltd | Real estate | 2024 |
| Deep Sea Logistics Limited | Transport & logistics | 2023 |
| Deepbluenortheast Ltd | Agriculture & fishing | 2025 |
| Deepfields Property Management Limited | Real estate | 2002 |
| Deepfields Property Services Limited | Construction | 2015 |
| DEF Holdings Limited | Information & communication | 2015 |
| DEF Software Limited | Information & communication | 2009 |
| Defender Court Management Limited | Households | 1999 |
| Defender Holdings Limited | Financial services | 2022 |
| Defengcon Ltd | Professional & scientific | 2026 |
| Defile Normal Ltd | Information & communication | 2026 |
| Deis Services Ltd | Construction | 2023 |
| Dejet Ltd | Wholesale & retail | 2025 |
| Dejo Technologies Limited | Information & communication | 2024 |
| DEL Buono Limited | Arts & recreation | 2010 |
| DEL Taylor Construction Limited | Construction | 2014 |
| Deli 150 Ltd | Hospitality | 2024 |
| Deli Chef 4 Hire Ltd | Hospitality | 2024 |
| Deli Two Twenty Limited | Hospitality | 2019 |
| Delicefood Ltd | Manufacturing | 2021 |
| Delish-Dish Limited | Hospitality | 2024 |
| Delly Foodstuffs Ltd | Hospitality | 2025 |
| Delta Omega Ltd | Professional & scientific | 2026 |
| Deluxe Kitchens & Bathrooms Ltd | Construction | 2024 |
| Deluxe Tree Surgeons Ltd | Agriculture & fishing | 2015 |
| Deluxe Windows and Doors Ltd | Construction | 2022 |
| Demnox Limited | Wholesale & retail | 1977 |
| Dene Mews Management Company Limited | Other services | 2002 |
| Dent Tech (NE) Limited | Manufacturing | 2007 |
| DEO Donante Ltd | Health & social care | 2023 |
| DEP Pubs Limited | Hospitality | 2023 |
| Deposit Protect Ltd | Administrative & support | 2025 |
| Derevelation Studios Limited | Manufacturing | 2022 |
| Derma Express Ltd | Wholesale & retail | 2025 |
| Dermal Perfect Ltd | Administrative & support | 2022 |
| Deroche Ltd | Other services | 2019 |
| Derrytony Limited | Other services | 2024 |
| Derwent Manor Ltd | Hospitality | 2013 |
| Derwenthurst (Ryhope) Club Limited | Hospitality | 1946 |
| Desanext Ltd | Information & communication | 2026 |
| Desco (2011) Limited | Professional & scientific | 2011 |
| Desco (Design & Consultancy) Limited | Professional & scientific | 1998 |
| Descora Ltd | Construction | 2015 |