| See'Da Pictures Limited | Information & communication | 2013 |
| Seen Premium Eyewear Ltd | Wholesale & retail | 2025 |
| Sefton Analytics Limited | Information & communication | 2025 |
| Self Financial Planners Limited | Financial services | 1977 |
| Self Storage on Demand Limited | Administrative & support | 2025 |
| Self Storage Stratford Limited | Administrative & support | 2020 |
| Semenstore Limited | Agriculture & fishing | 2009 |
| Send Flwrs Ltd | Information & communication | 2024 |
| Sendsible Limited | Education | 2025 |
| Senssports Limited | Information & communication | 2024 |
| Sentovex Ltd | Wholesale & retail | 2026 |
| Servicedek Ltd | Other services | 2020 |
| Setpiece Design Limited | Professional & scientific | 2025 |
| Setpoint Design Ltd | Professional & scientific | 2019 |
| Setsquare Creative Solutions Limited | Information & communication | 2011 |
| SFJ Collective Ltd | Other services | 2026 |
| SG Compliance Ltd | Financial services | 2014 |
| Sgaj Cardiac Management Ltd | Health & social care | 2019 |
| Shake and Batch Ltd T/A Tableread Limited | Education | 2018 |
| Shakespeare Cycles Limited | Manufacturing | 2025 |
| Shakespeare Distillery Limited | Manufacturing | 2015 |
| Shakespeare Holidays Limited | Real estate | 2011 |
| Shakespeare Management Services Limited | Real estate | 2014 |
| Shakespeare Media Ltd | Professional & scientific | 2014 |
| Shakespeare Partnership Limited | Real estate | 2006 |
| Shakespeare Property Investment Limited | Real estate | 2018 |
| Shakespeare Revue Company Ltd | Arts & recreation | 2013 |
| Shakespeare Spit Roast Limited | Hospitality | 2010 |
| Shakespeare's England Ltd | Administrative & support | 2012 |
| Shakespeares Service Centre Limited | Wholesale & retail | 2001 |
| Shandwick Investments Limited | Extraterritorial | 2015 |
| Shared-Solutions Limited | Professional & scientific | 1994 |
| Shareway Trading Co Ltd | Wholesale & retail | 2020 |
| Sheldawe Limited | Households | 2005 |
| Shelfield Management Limited | Professional & scientific | 2015 |
| Shenzik Homes Limited | Real estate | 2020 |
| Sherbourne Limited | Professional & scientific | 2019 |
| Sherwood & Associates Ltd | Real estate | 2003 |
| Shines Environmental Company Ltd | Construction | 2010 |
| Shire Marine Limited | Administrative & support | 2010 |
| Shire Oak Landscapes Midlands Ltd | Administrative & support | 2011 |
| Shire Oak Plant Services Ltd. | Extraterritorial | 2010 |
| Shire Vehicle Services Limited | Professional & scientific | 2024 |
| Shobha Ltd | Wholesale & retail | 2020 |
| Shortmove Group Limited | Hospitality | 2017 |
| Shottery Cottage (Stratford Upon Avon) Limited | Real estate | 2025 |
| Showem Entertainment Ltd | Information & communication | 1998 |
| Shower Power Ltd | Manufacturing | 2018 |
| Shree Asset Management Limited | Financial services | 2024 |
| Shrieves Walk Management Limited | Real estate | 2024 |
| Shrivatsa Limited | Professional & scientific | 2007 |
| Shurmer Electrical Limited | Construction | 2018 |
| Sicca Pubs Ltd | Hospitality | 2024 |
| Sigma Cleaning Ltd | Administrative & support | 2024 |
| Sigma Property Management Limited | Real estate | 2003 |
| Significance Developments Ltd | Real estate | 2019 |
| Significance Holdings Ltd | Financial services | 2019 |
| Silk Design & Construction Limited | Construction | 2021 |
| Silk Motors Limited | Wholesale & retail | 2003 |
| Silkwood Property (West Midlands) Limited | Real estate | 2020 |
| Silver Griffin DSC Limited | Professional & scientific | 2025 |
| Silver Startups Ltd | Professional & scientific | 2022 |
| Silver Stream Management Limited | Households | 2026 |
| SIM61 Limited | Wholesale & retail | 2020 |
| Simberhill Limited | Construction | 2002 |
| Simla Indian Cuisine Ltd | Hospitality | 2025 |
| Simnir Ltd | Education | 2007 |
| Simon Rowberry Consulting & Support Limited | Administrative & support | 2004 |
| Simon Williams Tuition Limited | Education | 2015 |
| Simple PAY Services Ltd | Administrative & support | 2023 |
| Simpler by Design Ltd. | Wholesale & retail | 2013 |
| Simplex Recruitment Limited | Administrative & support | 2015 |
| Simply Sausage Limited | Professional & scientific | 2011 |
| Simpson Sound and Vision Limited | Administrative & support | 2007 |
| Sims Foundry Limited | Manufacturing | 2011 |
| Sims Garden Machinery Limited | Wholesale & retail | 1935 |
| Sino Trading Limited | Professional & scientific | 2009 |
| SIP 'N' Swig Ltd | Hospitality | 2024 |
| Sirna Limited | Professional & scientific | 2016 |
| Siskin Consultancy Limited | Information & communication | 2008 |
| Site TEC Limited | Wholesale & retail | 2007 |
| Sixth Sense VPA Ltd | Administrative & support | 2024 |
| SJ Building S.O.A Ltd | Construction | 2013 |
| SJ Hancock (Bricklayers) Limited | Extraterritorial | 2011 |
| SJ Kwon Limited | Agriculture & fishing | 2017 |
| SJ Plank Builders Limited | Construction | 2003 |
| SJB Precision Engineering Limited | Manufacturing | 2003 |
| SJR Macleod Ltd | Professional & scientific | 2025 |
| SK August Ltd | Real estate | 2025 |
| SK Stratford Developments Ltd | Construction | 2026 |
| Sketts Associates Limited | Hospitality | 2001 |
| Skin and Soul Ltd | Other services | 2023 |
| Skin by Doctors Ltd | Health & social care | 2023 |
| Skinxstratford Limited | Wholesale & retail | 2026 |
| SKM & AM Limited | Hospitality | 2016 |
| Sleepydot Limited | Real estate | 2025 |
| SLJ Accountants Limited | Professional & scientific | 2020 |
| Sllp 428 Limited | Administrative & support | 2022 |
| SM Stratford Ltd | Hospitality | 2017 |
| Smallsmart Ltd | Wholesale & retail | 2021 |