| Roclay Limited | Professional & scientific | 2015 |
| Roel Limited | Professional & scientific | 2011 |
| Rogers Medical Services Limited | Health & social care | 2013 |
| Rolo's Signaling Solutions Limited | Construction | 2025 |
| Romona Clae Management Ltd | Arts & recreation | 2025 |
| Root Puller Ltd. | Arts & recreation | 2021 |
| Ropevale Limited | Construction | 1982 |
| Rose Rock House Carers Ltd | Manufacturing | 2021 |
| Rose Wine Ltd. | Wholesale & retail | 2021 |
| Rosebird Developments Limited | Real estate | 2011 |
| Rosehip & Co. Ltd | Real estate | 2022 |
| Rother Street Arts House Enterprise Ltd | Hospitality | 2025 |
| Round Box Enterprises Ltd. | Health & social care | 2016 |
| Roundstone Nurseries Limited | Wholesale & retail | 2018 |
| Routley & Scott Ltd | Wholesale & retail | 2015 |
| Rowley Lodge Limited | Real estate | 2012 |
| Rowlo (USA) Limited | Financial services | 2020 |
| Rowlo Ltd | Financial services | 2020 |
| Rowlo UK Limited | Financial services | 2025 |
| Rowlo Wuffes Limited | Financial services | 2025 |
| RSC Enterprise Limited | Wholesale & retail | 1989 |
| RSC Matilda Australasia Limited | Arts & recreation | 2015 |
| RSC Productions Limited | Arts & recreation | 2011 |
| RSC Touring Limited | Arts & recreation | 2017 |
| RSE (Midlands) Ltd | Construction | 2024 |
| RSH Events Ltd | Administrative & support | 2016 |
| RST Pension Scheme Trustees Limited | Professional & scientific | 2022 |
| RT Events Limited | Administrative & support | 2019 |
| RTL Nominees 1 Limited | Real estate | 2023 |
| Rugby Osteopathic Centre Limited | Health & social care | 2005 |
| Rugbytots (Solihull and Stratford) Ltd | Arts & recreation | 2024 |
| Ruggieri Consulting Ltd | Professional & scientific | 2023 |
| Rwmoss Research Ltd | Professional & scientific | 2020 |
| Ryepiece Orchard Ltd | Households | 2019 |
| Ryman Capital Limited | Financial services | 2025 |
| S a S Aujla Limited | Hospitality | 2024 |
| S E Technical Services Ltd | Professional & scientific | 2026 |
| S J Nurdin Construction Limited | Construction | 2011 |
| S K Smarttech Limited | Manufacturing | 2019 |
| S M H Management Investment Ltd | Professional & scientific | 2019 |
| S R Baldwyn Limited | Manufacturing | 2012 |
| S&E (UK) Ltd | Real estate | 2002 |
| S&J Holistic Health Ltd | Health & social care | 2026 |
| S&K Garden Services Ltd | Administrative & support | 2017 |
| S&S Food Services Ltd | Hospitality | 2024 |
| S.D. Constable Limited | Construction | 2002 |
| S.J. Hancock Limited | Construction | 2007 |
| S.R.S. Frigadon Limited | Wholesale & retail | 2001 |
| Saanvika Technologies Limited | Information & communication | 2016 |
| Sacn Consulting Limited | Administrative & support | 2014 |
| Sacred Skin Medical Aesthetics Ltd | Health & social care | 2026 |
| SAD Kitchen Ltd | Hospitality | 2024 |
| Sadita (UK) Limited | Financial services | 2016 |
| Safety Sprout Ltd | Professional & scientific | 2025 |
| Saffron Oak Ltd | Manufacturing | 2024 |
| Saige Longlife Decking Limited | Wholesale & retail | 2010 |
| Saint Living Limited | Construction | 2023 |
| Salerno Holdings Limited | Professional & scientific | 2015 |
| SAM Donovan Financial Services Limited | Financial services | 2020 |
| SAM Rose Ltd | Real estate | 2019 |
| Sammi International Transport Ltd | Transport & logistics | 2018 |
| Sandell Group (UK) Limited | Construction | 2003 |
| Sandell Interiors Limited | Construction | 2012 |
| Sandell Management Limited | Construction | 2012 |
| Sandell Special Projects Limited | Construction | 2012 |
| Sanders Consultancy Ltd | Professional & scientific | 2023 |
| Sandlpropertycare Ltd | Administrative & support | 2025 |
| Sanno Ltd | Health & social care | 2020 |
| Saphera Consulting Limited | Professional & scientific | 2025 |
| Sapphire Partnerships Limited | Health & social care | 2009 |
| Sara VON Sydow Limited | Professional & scientific | 2024 |
| Saradar's Limited | Real estate | 2020 |
| Sarah Cobley Consultancy Limited | Administrative & support | 2021 |
| Sarah Farrington Interior Design Ltd | Professional & scientific | 2018 |
| Sasquatch BBQ Limited | Hospitality | 2023 |
| Sasvat Global Limited | Hospitality | 2024 |
| Savco Ventures Limited | Information & communication | 2019 |
| Savinson & Co Ltd | Wholesale & retail | 2019 |
| Saye Enterprises Ltd | Financial services | 2012 |
| SBT Trading Limited | Wholesale & retail | 1996 |
| Scaleup Strategies Limited | Professional & scientific | 2024 |
| Scalp Juice Limited | Manufacturing | 2026 |
| Scandinavian Skincare (Holdings) UK Ltd | Financial services | 2018 |
| Scapeworx Ltd | Administrative & support | 2026 |
| Scarlett's Cakery Limited | Professional & scientific | 2015 |
| Scathach Ltd | Information & communication | 2022 |
| SCB Associates Limited | Professional & scientific | 2007 |
| Schooldashboard Ltd | Information & communication | 2026 |
| SCM Advisory Ltd | Professional & scientific | 2024 |
| Scots and Clans Ltd | Wholesale & retail | 2025 |
| Scott Cater Skip Hire Ltd | Water & waste | 2018 |
| Scotts Electrical Contractors (UK) Ltd | Construction | 2012 |
| Scotts of Stratford Ltd | Wholesale & retail | 2012 |
| Scott’S Homes Ltd | Construction | 2020 |
| SCREEN2SCREEN Media Ltd | Information & communication | 2019 |
| Sean Russell Consulting Limited | Professional & scientific | 2024 |
| Seaside Hideaways Limited | Hospitality | 2021 |
| Seaspray Shun Limited | Hospitality | 2024 |
| Secure Travel Solutions & Othello Taxis Ltd | Financial services | 2025 |
| Secure Travel Solutions Ltd | Transport & logistics | 2002 |