| Screamin' Beans Coffee Limited | Hospitality | 2025 |
| Scriven Design Limited | Professional & scientific | 2012 |
| Scriven Holdings Limited | Financial services | 2020 |
| Scriven Property Solutions Limited | Extraterritorial | 2009 |
| Sctimber Ltd | Wholesale & retail | 2021 |
| SD Electrical (Birmingham) Limited | Construction | 2018 |
| SD Marketing & Retail Ltd | Wholesale & retail | 2019 |
| SD Merchant Limited | Wholesale & retail | 2025 |
| SDF Bird Proofing Services Limited | Other services | 2021 |
| SDF Birdproofing Products Limited | Manufacturing | 2024 |
| Sdjt Financial Limited | Professional & scientific | 2018 |
| SDS Groundbreaking Ltd | Construction | 2018 |
| Seah Traders Limited | Wholesale & retail | 2026 |
| Sealable Limited | Information & communication | 2026 |
| Sean Emmett 123 Ltd | Construction | 2025 |
| Sean Miles Limited | Extraterritorial | 2025 |
| Sean Power Limited | Wholesale & retail | 2011 |
| Seanco Limited | Real estate | 2025 |
| SEC Investments Ltd | Real estate | 2017 |
| Second Central Properties (West Midlands) Limited | Real estate | 1989 |
| Sector Homes Limited | Real estate | 2002 |
| Sectorformat Limited | | 1987 |
| Secure Composite Doors Limited | Construction | 2022 |
| Secure Information Solutions Ltd | Information & communication | 2017 |
| Secure-Fit Windows and Doors Ltd | Professional & scientific | 2023 |
| Securenet Systems Limited | Other services | 2020 |
| Securigate Ltd | Administrative & support | 2021 |
| Securitek Limited | Administrative & support | 2004 |
| Security Link Services Limited | Construction | 1996 |
| SEF Property Holdings Ltd | Real estate | 2026 |
| Select Hardware Limited | Wholesale & retail | 1979 |
| Select Steel Erecting Services Ltd | Real estate | 2026 |
| Self Love Aesthetics Ltd | Other services | 2021 |
| Senash Utilities Limited | Construction | 2024 |
| Send Healthcare Limited | Health & social care | 2015 |
| Senses Web Solutions Ltd | Information & communication | 2011 |
| September Ventures Ltd | Financial services | 2019 |
| Serafina Holdings Ltd | Financial services | 2024 |
| Serenity Hair Kinver Limited | Other services | 2012 |
| Serfis Construction & Engineering Limited | Construction | 1978 |
| Sestra Living UK Ltd | Wholesale & retail | 2020 |
| Severn Valley Holdings Limited | Professional & scientific | 2003 |
| Severn Valley Wines Limited | Wholesale & retail | 1997 |
| Sevlow Ltd | Professional & scientific | 2018 |
| SFC Holdings (2026) Limited | Real estate | 2026 |
| Sgbb Investments Ltd | Real estate | 2025 |
| Sha-Mo Ltd | Hospitality | 2018 |
| Shadowtechautos Ltd | Wholesale & retail | 2026 |
| Shadwell Park Limited | Construction | 2002 |
| Shahana Shawarma LYE Ltd | Hospitality | 2025 |
| Shaheen's Restaurant Ltd | Hospitality | 2018 |
| Shard Haven Estates Ltd | Real estate | 2026 |
| Shaws (UK) Limited | Construction | 2009 |
| Shazam Productions Midlands Holdings Ltd | Administrative & support | 2025 |
| Shazam Productions Midlands Limited | Administrative & support | 2022 |
| Sheds and Things Limited | Wholesale & retail | 2011 |
| Shelby Eleven Ltd | Hospitality | 2024 |
| Shelby Wood Wool Limited | Manufacturing | 2022 |
| Shellgrant Productions Limited | Information & communication | 2016 |
| Shelton Public Sector Consultancy Limited | Administrative & support | 2007 |
| Shepway Cyber Services Ltd | Information & communication | 2020 |
| Shepway Ltd | Information & communication | 2020 |
| Shervingtons Limited | Construction | 2014 |
| Shifah Health Care Limited | Health & social care | 2014 |
| Shipley Group Limited | Financial services | 2019 |
| Shipley Weston Electrical Ltd | Construction | 2010 |
| Shipway Consulting Ltd | Professional & scientific | 2013 |
| Shire Developments (Shropshire) Limited | Administrative & support | 2007 |
| Shopus Ltd | Wholesale & retail | 2018 |
| Shot Darts UK Limited | Wholesale & retail | 2024 |
| Shovel Inn (LYE) Limited | Hospitality | 2005 |
| Show UP Better Ltd | Professional & scientific | 2024 |
| Shropshire Marketing Ltd | Professional & scientific | 2024 |
| Shropshire Tractors & Machinery Limited | Agriculture & fishing | 2022 |
| Siav Limited | Construction | 2008 |
| Siddha Baba Ltd | Hospitality | 2023 |
| Sidekick Mentoring & Training CIC | Education | 2025 |
| Sigma Core Ltd | Administrative & support | 2018 |
| Signature Electrical Services Limited | Construction | 2017 |
| Silantlea Limited | Wholesale & retail | 1994 |
| Silver Shield Financial Limited | Financial services | 2025 |
| Silvertree Project Services Ltd | Information & communication | 2014 |
| Simi Sara Ltd | Health & social care | 2018 |
| Simon Cooper Solutions Limited | Administrative & support | 2015 |
| Simon Harris and Co Limited | Extraterritorial | 1999 |
| Simon Meddings Associates Limited | Professional & scientific | 2009 |
| Simon Pattison Consulting Services Ltd | Extraterritorial | 2024 |
| Simple Approach Limited | Other services | 2023 |
| Simply Stocked Limited | Wholesale & retail | 2025 |
| Simply-One Limited | Hospitality | 2025 |
| Simply.Shop Ltd | Wholesale & retail | 2016 |
| Simtaf Limited | Wholesale & retail | 2013 |
| Simtaf Properties Ltd | Real estate | 2020 |
| Sinclair Properties (Birmingham) Ltd | Construction | 2020 |
| Singh Solicitors Limited | Professional & scientific | 2016 |
| Singhs Farm Ltd | Agriculture & fishing | 2026 |
| Sinsa Ltd | Construction | 2026 |
| Sipso Ltd | Wholesale & retail | 2025 |
| SIR Plumbing & Heating Limited | Construction | 2022 |
| Sirae Properties Limited | Real estate | 2024 |