| RS Access Solutions Limited | Wholesale & retail | 2024 |
| RS LYE Limited | Wholesale & retail | 2021 |
| RSK92 Consultants Ltd | Information & communication | 2022 |
| RST Display Limited | Wholesale & retail | 2021 |
| RSW Digital Ltd | Administrative & support | 2013 |
| RT Paraplanning Solutions Ltd | Financial services | 2018 |
| Rumsoft Solutions Limited | Information & communication | 2009 |
| Running 4 Women Limited | Arts & recreation | 2003 |
| Rushworth & Co.(Sowerby Bridge)Limited | Professional & scientific | 1951 |
| Russell Electronic Security Systems Ltd | Administrative & support | 2016 |
| Russell Homes (Stourbridge) Limited | Real estate | 2016 |
| Ruth Francis Strategic Communications Ltd | Administrative & support | 2018 |
| RVM Holdings Limited | Professional & scientific | 2004 |
| Rwjb Limited | Real estate | 2026 |
| RWT Consultants Limited | Professional & scientific | 2022 |
| Ry-Knows Material Handling Limited | Manufacturing | 2024 |
| Ryan Darbyshire Farrier Ltd | Agriculture & fishing | 2021 |
| Rykav Construction Limited | Construction | 2002 |
| Ryse Properties Limited | Real estate | 2020 |
| RZ Global Ltd | Manufacturing | 2026 |
| RZ Power Ltd | Wholesale & retail | 2024 |
| S & DG Holidays Ltd | Administrative & support | 2020 |
| S & J Catering Services Limited | Hospitality | 2023 |
| S a Leisure Services Ltd | Other services | 2022 |
| S and C Building Construction Ltd | Construction | 2021 |
| S B Property Management Services Ltd | Construction | 2018 |
| S C Commercial Car Solutions Ltd | Transport & logistics | 2024 |
| S C Hancock Ltd | Professional & scientific | 2013 |
| S Clarke Quality Interiors Ltd | Construction | 2011 |
| S E Catering Limited | Hospitality | 2015 |
| S Frost Autotech Limited | Manufacturing | 2016 |
| S G Fitzpatrick Limited | Information & communication | 2016 |
| S Garner Locum Services Ltd | Health & social care | 2002 |
| S Harris & Sons Limited | Construction | 2002 |
| S Hill Homes Ltd | Real estate | 2025 |
| S J Autos Renault Specialist Limited | Wholesale & retail | 2013 |
| S J Furnaces Ltd | Administrative & support | 2018 |
| S J Hindle Limited | Information & communication | 2013 |
| S J Mortgage Solutions Ltd | Financial services | 2006 |
| S J Peformance Limited | Other services | 2019 |
| S R G Electrical Services Limited | Construction | 2018 |
| S Shah Ltd | Wholesale & retail | 2024 |
| S&S Industries Limited | Households | 2025 |
| S-Store Limited | Information & communication | 2003 |
| S. & B. Tools Ltd. | Manufacturing | 1990 |
| S2 Networks Limited | Information & communication | 2016 |
| S2 Technology Group Limited | Information & communication | 2009 |
| S3 (Medical Aesthetics) Limited | Other services | 2012 |
| SA Auto Parts Ltd | Wholesale & retail | 2020 |
| SA Motors Ltd | Wholesale & retail | 2026 |
| Sabir TM Ltd | Construction | 2025 |
| SABRI123 Ltd | Health & social care | 2024 |
| Sacha Jones Makeup Ltd | Other services | 2020 |
| Sacs (Midlands) Limited | Information & communication | 1999 |
| Safe & Secure Locksmiths Ltd | Manufacturing | 2010 |
| Safe Journey Car Seats Limited | Wholesale & retail | 2025 |
| Safe to BE CIC | Education | 2025 |
| Safe Waste Technology Limited | Professional & scientific | 2020 |
| Safesource IT Limited | Information & communication | 2009 |
| Safir Build Limited | Construction | 2021 |
| Sage Independent Mortgage Advice Limited | Financial services | 2005 |
| Sage Telecom Limited | Information & communication | 2004 |
| Saha Enterprises Ltd | Hospitality | 2020 |
| Saifee Healthcare Limited | Manufacturing | 2016 |
| Sales International Limited | Wholesale & retail | 2015 |
| Salient Enterprise Solutions Ltd | Professional & scientific | 2000 |
| Sallyo Travel Ltd | Administrative & support | 2025 |
| Saltbrook Trading Limited | Wholesale & retail | 2013 |
| SAM Gifts Ltd | Wholesale & retail | 2026 |
| SAM Parr Marketing Limited | Professional & scientific | 2011 |
| Samuel Lewis Limited | Manufacturing | 1937 |
| Samy Rock Gaming Ltd | Wholesale & retail | 2026 |
| Sanctuary Estates Global Ltd | Real estate | 2020 |
| Sandeep R Deshmukh Ltd | Health & social care | 2025 |
| Sanders Sports Consulting Ltd | Professional & scientific | 2018 |
| Sandhu Bros Garage Ltd | Wholesale & retail | 2024 |
| Sandland Auto Logistics Ltd | Transport & logistics | 2022 |
| Sandwell Roofing Limited | Construction | 2004 |
| Sandy Road Consulting Limited | Information & communication | 2022 |
| Sanwu House 2023 Ltd | Hospitality | 2023 |
| Sapcote Commercial Bodies Limited | Manufacturing | 2016 |
| Sapphire Steels Limited | Wholesale & retail | 2003 |
| Sarah's Gardening Ltd | Administrative & support | 2025 |
| Savage Headway Ltd | Health & social care | 2019 |
| Savoy Steel Doors & Louvers Ltd | Other services | 2025 |
| Savva Bars Co Ltd | Hospitality | 2016 |
| Savvy MC Ltd | Extraterritorial | 2020 |
| SAW Mart Limited | Wholesale & retail | 2005 |
| SBK Music Limited | Information & communication | 2020 |
| SC Venture Properties Limited | Real estate | 2026 |
| Scandiarc Ltd | Construction | 2026 |
| Scandus Design Limited | Manufacturing | 2012 |
| Scare Tickets Ltd | Wholesale & retail | 2026 |
| Scarlet and Green Ltd | Professional & scientific | 2026 |
| Scent Shield Limited | Administrative & support | 2023 |
| Schoodle Ltd | Education | 2019 |
| School of Hope Ltd. | Education | 2024 |
| School Trips Limited | Administrative & support | 2021 |
| Scott & Bell Ltd | Financial services | 2023 |
| Scottwood Timber Limited | Wholesale & retail | 2020 |