| Staffordshire Orthopaedic Foot and Ankle Limited | Health & social care | 2019 |
| Staffordshire Paediatric Occupational Therapy Limited | Health & social care | 2019 |
| Staffordshire Refractory Services Limited | Administrative & support | 2002 |
| Staffordshire Solar Ltd | Construction | 2023 |
| Staffordshire Steam Cleaning Solutions Ltd | Administrative & support | 2026 |
| Staffordshire Tool Hire & Sales Limited | Wholesale & retail | 2007 |
| Staffordshire Venture Ltd | Health & social care | 2012 |
| Staffs Building Company Ltd | Construction | 2012 |
| Stainless Threaded Fasteners Limited | Extraterritorial | 1985 |
| Stanway Holdings Ltd | Financial services | 2026 |
| Star Private Hire Staffs Ltd | Transport & logistics | 2019 |
| Stayinjoinin Limited | Administrative & support | 2013 |
| Steel City Knives Limited | Wholesale & retail | 2026 |
| Stellify Capital Limited | Financial services | 2018 |
| Sterling Transport Consultancy Limited | Professional & scientific | 2018 |
| Steven.Burbridge Ltd | Hospitality | 2015 |
| Stfl Services Ltd | Information & communication | 2014 |
| Stitch Architecture Ltd | Extraterritorial | 2012 |
| Stone (Stoke) Clip N Climb Ltd | Arts & recreation | 2017 |
| Stone Accountant (Staffs) Ltd | Professional & scientific | 2022 |
| Stone Baked Limited | Wholesale & retail | 2013 |
| Stone Bakehouse Limited | Manufacturing | 2023 |
| Stone Barber Shop Limited | Other services | 2025 |
| Stone Builders Merchants Ltd | Construction | 2017 |
| Stone Building Services Limited | Construction | 2002 |
| Stone Car and Truck Centre Limited | Wholesale & retail | 2008 |
| Stone Carpet & Flooring Ltd | Wholesale & retail | 2023 |
| Stone Carpets & Beds Ltd | Wholesale & retail | 2017 |
| Stone Chiro Clinic Limited | Health & social care | 2019 |
| Stone Classic Cars Ltd | Professional & scientific | 2020 |
| Stone Community Hub Ltd | Hospitality | 2007 |
| Stone Day Nursery Limited | Education | 2026 |
| Stone Developments Limited | Real estate | 2012 |
| Stone Edge Consultants Limited | Professional & scientific | 2026 |
| Stone Events Ltd | Hospitality | 2025 |
| Stone Food and Drink Festival C.I.C. | Arts & recreation | 2006 |
| Stone Golf Centre Limited | Arts & recreation | 2019 |
| Stone Golf Club Limited(The) | Arts & recreation | 1924 |
| Stone Hockey and Rugby Club Ltd | Arts & recreation | 2022 |
| Stone Hockey and Rugby Club Trading Ltd | Arts & recreation | 2022 |
| Stone Legal Services Limited | Professional & scientific | 2026 |
| Stone Leisure Ltd | Hospitality | 2018 |
| Stone Local Logistics Ltd | Transport & logistics | 2023 |
| Stone Medical Clinic Ltd | Health & social care | 2021 |
| Stone Mobiles Ltd | Wholesale & retail | 2023 |
| Stone Old Alleynians F.C. Ltd | Hospitality | 2025 |
| Stone Payroll Limited | Financial services | 2019 |
| Stone Scaffolding (Hire) Limited | Construction | 2014 |
| Stone Shoe Repairs Limited | Other services | 2019 |
| Stone Traders Group Ltd | Administrative & support | 2018 |
| Stone Tyre Repairs Limited | Wholesale & retail | 2011 |
| Stone Valley Lodge Ltd | Arts & recreation | 2019 |
| Stone Van Hire Limited | Administrative & support | 2012 |
| Stonefield Court Management Limited | Households | 1992 |
| Stonefield Garage Limited | Wholesale & retail | 2015 |
| Stonegate Wealth Management Limited | Professional & scientific | 2009 |
| Straight & Narrowboats Ltd | Manufacturing | 2025 |
| Strangways Capital Limited | Construction | 2005 |
| Strangways Holdings Limited | Administrative & support | 2017 |
| Strangways Investments Limited | Real estate | 1999 |
| Strathgarve Estates Limited | Real estate | 2004 |
| Streat Food Stone Ltd | Hospitality | 2022 |
| Streat Street Food Ltd | Hospitality | 2018 |
| Street Dance Academy Limited | Arts & recreation | 2011 |
| Studio B Barre Fit Ltd | Arts & recreation | 2020 |
| Studio Four (Stone) Ltd | Other services | 2024 |
| Summer Field Court Community Shop Ltd | Wholesale & retail | 2010 |
| Summit Security Solutions Ltd | Construction | 2006 |
| Sunshine Nails Limited | Other services | 2019 |
| Surfnode Ltd | Information & communication | 2025 |
| SV Consulting Engineering Limited | Professional & scientific | 2009 |
| Swan Ventures Ltd | Professional & scientific | 2016 |
| Swanline Group Limited | Manufacturing | 2000 |
| Swanline Holdings Ltd | Financial services | 2021 |
| Sweethearts Hair Limited | Wholesale & retail | 2015 |
| SWH Reinforcements Ltd | Construction | 2020 |
| Swift Bodies Ltd | Manufacturing | 2026 |
| Swiss Iconic Limited | Wholesale & retail | 2011 |
| Switchtec Components Limited | Wholesale & retail | 1991 |
| Switchtec Electronics Limited | Extraterritorial | 2005 |
| Switchtec Limited | Wholesale & retail | 1982 |
| Swtco Limited | Manufacturing | 2019 |
| Swynnerton Barns Management Limited | Households | 2019 |
| Swynnerton Gardens Residents Association Limited | Households | 1969 |
| Syncterface Limited | Information & communication | 2007 |
| Synetica Limited | Professional & scientific | 2008 |
| T&A-Mb Ltd | Real estate | 2024 |
| Talbot and Green Holdings Ltd | Hospitality | 2018 |
| Talbott's Biomass Energy Systems Ltd | Manufacturing | 2007 |
| Taplow Grange Limited | Real estate | 2003 |
| TBB Mechanical Services Ltd | Wholesale & retail | 2024 |
| TD Thermal Ltd | Wholesale & retail | 2005 |
| Tdjc Data Limited | Information & communication | 2012 |
| TE Nosce Ltd | Health & social care | 2017 |
| Team Creators Ltd | Health & social care | 2024 |
| Team SME Ltd | Administrative & support | 2021 |
| Tectrac Limited | Professional & scientific | 2024 |
| Telford Parogon Ltd | Hospitality | 2024 |
| Tetris Trading Limited | Construction | 2016 |
| TFM Events Ltd | Arts & recreation | 2026 |