| Sabit Limited | Manufacturing | 1989 |
| Safer Systems (U.K) Limited | Manufacturing | 1993 |
| Safndee Limited | Information & communication | 2010 |
| Sagray Properties Limited | Real estate | 2025 |
| Saith Properties Limited | Real estate | 2014 |
| Salesxchange Ltd | Administrative & support | 2016 |
| Sarcp | Other services | 2003 |
| Savoy Event Medical Services Ltd | Health & social care | 2022 |
| SC DRY Cleaning Stone Ltd | Other services | 2021 |
| School House Investments Limited | Professional & scientific | 2023 |
| School House Leisure Limited | Other services | 1998 |
| Scosau Limited | Wholesale & retail | 2015 |
| SDC 2013 Ltd. | Professional & scientific | 2013 |
| Sdrc Consulting Limited | Professional & scientific | 2009 |
| Sea Papasticles Ltd | Financial services | 2023 |
| Seagull Management Company Ltd | Information & communication | 2025 |
| Sealfast Limited | Real estate | 1985 |
| Secret Attic Software Limited | Information & communication | 2012 |
| Securican Ltd | Administrative & support | 2002 |
| Selcomp Ltd | Wholesale & retail | 2003 |
| Select Sports Horses Limited | Agriculture & fishing | 2014 |
| Senior Property Group Ltd | Real estate | 2025 |
| Servicevisual Limited | Extraterritorial | 2014 |
| SET in Stone Productions Ltd | Arts & recreation | 2025 |
| SET in Stone Wills and Lpas Ltd | Other services | 2023 |
| Shape Your Future Ltd | Health & social care | 2017 |
| Shaw Engineering Solutions Ltd | Manufacturing | 2019 |
| SHB Trading Limited | Information & communication | 2025 |
| Shear Genius (Staffs) Limited | Other services | 2017 |
| Sheen Botanical Labels Limited | Manufacturing | 2002 |
| Sheen Developments Limited | Professional & scientific | 2002 |
| Sheen Labels Limited | Manufacturing | 2007 |
| Sherwood Court Management (Stone) Limited | Households | 2017 |
| Shone Property Limited | Real estate | 2019 |
| Shrewsbury Parogon Ltd | Hospitality | 2024 |
| Signature Fence Panels Limited | Manufacturing | 2025 |
| Signed Frequency Ltd | Information & communication | 2026 |
| Silesia Flavours Limited | Wholesale & retail | 1996 |
| Simple Shared Healthcare Limited | Professional & scientific | 2016 |
| Sisterhood Care Limited | Health & social care | 2022 |
| SIT and Stay Ltd | Other services | 2025 |
| Sitepride Limited | Real estate | 2005 |
| SJ Employment Ltd | Professional & scientific | 2019 |
| Skills Made Simple Ltd | Professional & scientific | 2024 |
| Skillstent Ltd | Professional & scientific | 2025 |
| SKN Plus Academy Ltd | Wholesale & retail | 2025 |
| SKN Plus Group Ltd | Education | 2025 |
| Skyler Developments Ltd | Real estate | 2024 |
| SLG Limited | Information & communication | 2025 |
| Slimy Ruffians Ltd | Professional & scientific | 2012 |
| SM Washington Engineering Limited | Professional & scientific | 2023 |
| Smarty's Day Nursery (Stone) Limited | Education | 2011 |
| Smarty's Stars Nursery (Stone) Limited | Education | 2021 |
| SMC Editorial Solutions Limited | Information & communication | 2013 |
| Smith Brothers Roofing (Staffs) Ltd | Construction | 2026 |
| Smoothest Operator Limited | Administrative & support | 2025 |
| SMP Hair Clinic International Limited | Other services | 2017 |
| Snag the House Ltd | Professional & scientific | 2021 |
| Snazzybuys Ltd | Wholesale & retail | 2026 |
| Snow Shepherd Limited | Wholesale & retail | 1997 |
| Soaf Properties Limited | Real estate | 2024 |
| Society Coach Ltd | Other services | 2025 |
| Solum Surveying Holdings Limited | Construction | 2025 |
| Solum Surveying Limited | Construction | 2013 |
| Sonia Knight Deco Ltd | Construction | 2021 |
| Sorin Ltd | Wholesale & retail | 2019 |
| Soulbury Associates Limited | Information & communication | 1992 |
| South Cerney Outdoor (EOT) Limited | Extraterritorial | 2019 |
| South Snowdon Wharf Ltd | Real estate | 1992 |
| Sparsio Limited | Construction | 2019 |
| Spawnpoint for Kids Ltd | Manufacturing | 2025 |
| Specialist Joint Management Ltd | Professional & scientific | 2013 |
| Speech Aloud Ltd | Health & social care | 2022 |
| Spot Acre Equestrian Limited | Arts & recreation | 2008 |
| SRB Limited | Extraterritorial | 1999 |
| Sribm Services Limited | Health & social care | 2021 |
| SRM Recycling Ltd | Water & waste | 2026 |
| SRS Fried Chicken Ltd | Hospitality | 2026 |
| SRS Village Store Ltd | Wholesale & retail | 2022 |
| SSA Engineering Consultants Limited | Administrative & support | 2019 |
| SSS Gubbi Properties Limited | Real estate | 2024 |
| ST Dominic's Grammar School Brewood Limited | Education | 2017 |
| ST Dominic's Priory School (Stone) | Education | 2011 |
| ST Dominic's Property Investments Limited | Real estate | 2015 |
| ST Gabriel Estates Limited | Real estate | 2024 |
| ST James Investment Assets Limited | Real estate | 2014 |
| ST John's Granville Management Ltd | Households | 2023 |
| ST Philips (Channel Islands) Limited | Health & social care | 1996 |
| ST Philips Care Caledonia Limited | Health & social care | 2009 |
| ST Philips Care Limited | Professional & scientific | 1996 |
| ST Philips Care NO2 Limited | Construction | 2023 |
| ST Philips Care Trinity Limited | Health & social care | 2010 |
| ST Philips Educational Holdings Limited | Education | 2020 |
| ST Philips Hotels Wolverhampton Limited | Hospitality | 2025 |
| ST. Dominics Social Centre (Stone) Limited | Hospitality | 1998 |
| Stafford Electrical Services Ltd | Manufacturing | 2023 |
| Stafford Railway Circle Limited | Other services | 2010 |
| Staffordshire Coaching & Development Ltd | Education | 2023 |
| Staffordshire Electrical Testing Limited | Construction | 2015 |
| Staffordshire Glazing Solutions Limited | Construction | 2021 |