| Studio Lovatt Ltd | Wholesale & retail | 2017 |
| Studmount Ltd | Construction | 2025 |
| Stuffed Sandwich Bar Limited | Hospitality | 2026 |
| Sturge & Co Ltd | Professional & scientific | 2026 |
| Stylaffi Ltd | Information & communication | 2025 |
| Style House Group Ltd | Construction | 2025 |
| Style Interiors Ltd | Wholesale & retail | 2025 |
| Style Sanctuary Ltd | Administrative & support | 2024 |
| Style Tonic Limited | Other services | 2016 |
| Stylish Gates and Doors Ltd | Manufacturing | 2024 |
| Stylish Roller Doors Limited | Wholesale & retail | 2013 |
| Styperson Pope Limited | Professional & scientific | 2009 |
| SU Residential Services Limited | Financial services | 2024 |
| Subbie Tax Limited | Professional & scientific | 2018 |
| Subek Ltd | Wholesale & retail | 2025 |
| Subidee Pipe and Welding Installation Limited | Construction | 2020 |
| Subline Utilities Limited | Construction | 2024 |
| Subsmart Ltd | Extraterritorial | 2024 |
| Success Factor Limited | Professional & scientific | 2002 |
| Success Group Ltd | Health & social care | 2023 |
| Success Insights (UK) Limited | Professional & scientific | 2005 |
| Sudaisecom Ltd | Wholesale & retail | 2025 |
| SUE Crane Childrens Wear Limited | Wholesale & retail | 2016 |
| SUE KAY Limited | Hospitality | 2015 |
| SUE Tomkinson Consultancy Limited | Professional & scientific | 2011 |
| Sugarmill Live CIC | Arts & recreation | 2024 |
| SUI Generis Issues Limited | Administrative & support | 2018 |
| Sukare Aesthetics Ltd | Other services | 2025 |
| Sukh Exports Ltd | Wholesale & retail | 2025 |
| Suki's SOT Ltd | Hospitality | 2021 |
| Suko Ltd | Other services | 2025 |
| Sulis Vapes Limited | Wholesale & retail | 2024 |
| Sultana Residences Ltd | Real estate | 2025 |
| Sultanam Ltd | Other services | 2022 |
| Sultania Multi Service Ltd | Administrative & support | 2022 |
| Suma Logistics Ltd | Transport & logistics | 2024 |
| Sumkad Health Limited | Public administration | 2026 |
| Summer Street Developments Ltd | Construction | 2023 |
| Summerborn Boats Limited | Extraterritorial | 2004 |
| Summerborn Property Limited | Real estate | 2004 |
| Summit Access & Consultancy Ltd | Construction | 2025 |
| Summit Business Park Ltd | Construction | 2017 |
| Summit Cafe Ltd | Hospitality | 2025 |
| Summit HR Ltd | Administrative & support | 2025 |
| Summit Search Recruitment Ltd | Administrative & support | 2026 |
| Summit Steeplejacks Ltd | Construction | 2025 |
| Sun City Tanning & Beauty Ltd | Other services | 2026 |
| Sun Info Systems Ltd | Information & communication | 2022 |
| Sun Organisation Limited | Administrative & support | 1999 |
| Sundown Wood & Stone Ltd | Agriculture & fishing | 2026 |
| Sunkissed (Burslem) Ltd | Other services | 2023 |
| Sunlite Health Care Ltd | Health & social care | 2020 |
| Sunnyside Renovations Limited | Construction | 2016 |
| Sunrock Ventures Limited | Construction | 2016 |
| Sunset Hand Car Wash Ltd | Wholesale & retail | 2025 |
| Sunset Lighting Systems Ltd | Manufacturing | 2013 |
| Sunshine Construction and Building Ltd | Construction | 2023 |
| Sunshine Vera Holdings Limited | Real estate | 2022 |
| Sunshine Vista Property Ltd | Real estate | 2024 |
| Sunshine Vita Property Ltd | Real estate | 2015 |
| Sunshine Well CIC | Professional & scientific | 2026 |
| Suntrap Tanning Studio Ltd | Other services | 2023 |
| Suntuoso Properties Limited | Households | 2020 |
| Super Oriental Food Limited | Hospitality | 2022 |
| Super Saver Deals Ltd | Wholesale & retail | 2024 |
| Super-Rod Group Limited | Administrative & support | 2025 |
| Superbva Ltd | Wholesale & retail | 2024 |
| Supercraft Windows Limited | Extraterritorial | 2011 |
| Superfluz Global Consult Ltd | Administrative & support | 2025 |
| Superio Furniture Limited | Manufacturing | 2023 |
| Superior North Care Group Ltd | Health & social care | 2025 |
| Suppawt Ltd | Information & communication | 2015 |
| Supple Traders Ltd | Wholesale & retail | 2024 |
| Supplement Heaven Ltd | Wholesale & retail | 2022 |
| Supplement Junction Ltd | Wholesale & retail | 2016 |
| Support 7 Care Limited | Administrative & support | 2018 |
| Supported Living Gateway Limited | Professional & scientific | 2020 |
| Suppsko Ltd | Wholesale & retail | 2022 |
| Supreme Applications Ltd | Professional & scientific | 2017 |
| Supreme Fuels Limited | Other services | 2023 |
| Supreme Horseboxes Limited | Wholesale & retail | 2013 |
| Sure Clinic Ltd | Health & social care | 2014 |
| Sure Developments X Limited | Construction | 2025 |
| Sure Drive Motors Ltd | Wholesale & retail | 2026 |
| Sure Lock Homes Locksmiths Ltd | Construction | 2012 |
| Sure Step Stoke Limited | Construction | 2020 |
| Surecool Ltd | Wholesale & retail | 2003 |
| Surefeet Ltd | Health & social care | 2011 |
| Surfcasa Limited | Real estate | 2002 |
| Susan Rose China Limited | Manufacturing | 2018 |
| Sutherland Primary Academy | Education | 2011 |
| Sutherland Property Management Limited | Real estate | 2018 |
| Sutton Surfacing Limited | Construction | 2008 |
| Suttons Food Group Ltd | Hospitality | 2023 |
| Suttons Property Group Ltd | Real estate | 2026 |
| SVB Medical Limited | Health & social care | 2015 |
| SVB Property Limited | Real estate | 2020 |
| SVG IT Ltd | Information & communication | 2024 |
| SVK Holdings Limited | Financial services | 2020 |
| SVL Traders Ltd | Transport & logistics | 2025 |