| SPS Envirowall Limited | Construction | 2018 |
| Spse Investments Limited | Construction | 1989 |
| Spso Holdings Limited | Manufacturing | 2020 |
| SPT Plastering Ltd | Construction | 2021 |
| SPW Mechanical Engineers Limited | Manufacturing | 2008 |
| Spyder Balls Limited | Wholesale & retail | 2015 |
| Sqbe Limited | Information & communication | 2025 |
| Square Pizza 1 Limited | Hospitality | 2022 |
| Square Property Holdings Ltd | Real estate | 2026 |
| Squaretower Limited | Households | 1989 |
| SR Advisory (Stoke) Limited | Professional & scientific | 2025 |
| SR Force Ltd | Administrative & support | 2024 |
| SR Grandad Limited | Wholesale & retail | 2022 |
| SR Softco Limited | Information & communication | 2014 |
| SRB Designs Ltd | Manufacturing | 2025 |
| SRE Stoke Limited | Hospitality | 2021 |
| SRE Stoke Properties Limited | Real estate | 2022 |
| SRG Garages Limited | Wholesale & retail | 2014 |
| SRK Property Services Ltd | Real estate | 2020 |
| Srmnf Limited | Real estate | 2023 |
| SRS PVT Ltd | Health & social care | 2023 |
| SRW Advisory Ltd | Real estate | 2018 |
| SRW Capital Limited | Extraterritorial | 2024 |
| SRW Fire Detection Systems Ltd | Public administration | 2013 |
| SS & ST Ltd | Professional & scientific | 2013 |
| SS Enterprises Private Limited | Wholesale & retail | 2026 |
| SS Russell Taverns Ltd | Hospitality | 2022 |
| Ss-Logy Mortgage Consults Ltd | Financial services | 2025 |
| SSB Joinery Services Limited | Construction | 2020 |
| SSB Properties (Cheshire) Limited | Real estate | 2021 |
| Sscb Consultancy Limited | Professional & scientific | 2023 |
| SSD Estates & Enterprises Ltd | Real estate | 2024 |
| SSI Motorhouse Ltd | Wholesale & retail | 2024 |
| SSK Group of Company Ltd | Wholesale & retail | 2024 |
| SSM Catering Equipment Limited | Wholesale & retail | 2025 |
| SSR Stoke Ltd | Real estate | 2018 |
| SSR UK Group Limited | Hospitality | 2026 |
| Ssretailers Ltd | Wholesale & retail | 2025 |
| SSS Connect Limited | Transport & logistics | 2013 |
| SSS Home Hub Ltd | Real estate | 2025 |
| SSS Supershine Ltd | Administrative & support | 2025 |
| SST Property Development Ltd | Construction | 2022 |
| ST Active Together Ltd | Arts & recreation | 2026 |
| ST Albans Little Learners Nursery CIC | Education | 2008 |
| ST Athena Global Holdings Limited | Manufacturing | 2016 |
| ST Bart's Multi Academy Trust | Education | 2013 |
| ST Christophers Court (Stoke on Trent) Management Company Limited | Real estate | 2007 |
| ST Dragon Limited | Hospitality | 2024 |
| ST Georges Court Residents Association (Basford) Limited | Households | 2010 |
| ST Jude Properties Limited | Real estate | 2024 |
| ST Jude's Consultancy Limited | Financial services | 2007 |
| ST Mary's Anglican Academy | Administrative & support | 2017 |
| ST Mary's Local Shop Limited | Wholesale & retail | 2016 |
| ST UK Trans Ltd | Transport & logistics | 2022 |
| ST Wulstan's Musical Education Trust | Arts & recreation | 2004 |
| ST. Dominic's Independent Junior School Trust Limited | Education | 1980 |
| ST. James Facilities Management Ltd | Administrative & support | 2019 |
| ST. John's Priory School Limited | Education | 2000 |
| ST. Joseph's College Edmund Rice Academy Trust | Education | 2011 |
| ST. Mary's Convenience Store Ltd | Wholesale & retail | 2025 |
| ST. Vincent Mews Residents Association Limited | Households | 1997 |
| St.Maximilian Healthcare Ltd. | Health & social care | 2018 |
| ST1 Car Sales Limited | Wholesale & retail | 2022 |
| ST1 Maintenance and Glazing Limited | Construction | 2022 |
| ST2 Milton Care Home Ltd | Health & social care | 2018 |
| ST3 Recruitment Limited | Administrative & support | 2023 |
| ST3 Takeaway Ltd | Hospitality | 2025 |
| ST4 Holdings Ltd | Real estate | 2025 |
| ST8 Bars Ltd | Hospitality | 2024 |
| Stable Minds, Better Tomorrow CIC | Education | 2025 |
| Stace Skip Hire Ltd | Water & waste | 2026 |
| Stacey Adele's Creations Ltd | Other services | 2019 |
| Stacey Elizabeth Brearley Ltd | Extraterritorial | 2022 |
| Stacks of Tyres Ltd | Wholesale & retail | 2021 |
| Staff Design Company Ltd | Professional & scientific | 2021 |
| Stafford & Brooks Ltd | Wholesale & retail | 2024 |
| Stafford & District Model Engineering Society Limited | Other services | 1998 |
| Stafford BUS Centre Limited | Wholesale & retail | 2001 |
| Stafford Cars Ltd | Wholesale & retail | 2023 |
| Stafford Consultancy and Logistics Limited | Professional & scientific | 2025 |
| Stafford Window Cleaning Limited | Administrative & support | 2011 |
| Staffordshire & Cheshire Cleaning Services Limited | Administrative & support | 2010 |
| Staffordshire Access & Telematics Installation Ltd | Manufacturing | 2022 |
| Staffordshire Access Flooring Ltd | Construction | 2025 |
| Staffordshire Aggregate Solutions Ltd | Wholesale & retail | 2025 |
| Staffordshire and Cheshire Equine Assisted Psychotherapy CIC | Other services | 2017 |
| Staffordshire and Cheshire Septic Tank Specialists Ltd | Construction | 2024 |
| Staffordshire Angling Club Ltd | Agriculture & fishing | 2025 |
| Staffordshire Arbitration Ltd | Administrative & support | 2016 |
| Staffordshire Artificial Grass Limited | Construction | 2020 |
| Staffordshire Association for Black Lives Equality CIC | Other services | 2021 |
| Staffordshire Bifolds and Aluminium Limited | Construction | 2018 |
| Staffordshire Bushcraft CIC | Health & social care | 2024 |
| Staffordshire Car Painters Limited | Wholesale & retail | 2011 |
| Staffordshire Ceramics Ltd | Manufacturing | 2002 |
| Staffordshire Chambers of Commerce and Industry Ltd. | Other services | 1949 |
| Staffordshire Cleaning Ninja's Ltd | Administrative & support | 2023 |
| Staffordshire Commercial Vehicle Rental Ltd | Administrative & support | 2024 |
| Staffordshire Construction Services Ltd | Construction | 2014 |
| Staffordshire Consultancy Services Ltd | Administrative & support | 2023 |