| Sowdon Consultancy Ltd | Professional & scientific | 2025 |
| Sowerbys Stocktaking & Payroll Ltd. | Professional & scientific | 2009 |
| Soyut Consultancy Ltd | Information & communication | 2022 |
| SP Care Homes Ltd | Real estate | 2025 |
| SP Nursery Limited | Education | 2018 |
| SP Prestige Cars Ltd | Wholesale & retail | 2026 |
| SP Sushi Limited | Wholesale & retail | 2024 |
| Space AGE Building Products Limited | Wholesale & retail | 2005 |
| Space Chef Ltd | Manufacturing | 2019 |
| Space Engagers Ltd | Professional & scientific | 2025 |
| Spaint NLR Limited | Extraterritorial | 2007 |
| Span Media Ltd | Transport & logistics | 2004 |
| Spannered Limited | Wholesale & retail | 2023 |
| Spark & Forge Marketing Ltd | Professional & scientific | 2025 |
| Spark Engineering Solution Ltd | Manufacturing | 2024 |
| Spark Heat Electrical & Heating Solutions Ltd | Construction | 2023 |
| Spark Limited | Professional & scientific | 1998 |
| Spark to Your Success C.I.C. | Professional & scientific | 2020 |
| Sparkleen Consult Limited | Information & communication | 2024 |
| Sparkling Beauty Ltd | Other services | 2025 |
| Sparkshiftonline Ltd | Wholesale & retail | 2025 |
| Sparkx Solutions Ltd | Professional & scientific | 2025 |
| Sparrow Personnel Ltd | Administrative & support | 2025 |
| Spartan Environmental Ltd. | Professional & scientific | 2017 |
| Spartanism Ltd | Hospitality | 2013 |
| SPB Asset Ltd | Financial services | 2025 |
| SPD Builders Ltd | Construction | 2026 |
| Specialist 001 Limited | Administrative & support | 2025 |
| Specialist Building Materials Limited | Wholesale & retail | 1990 |
| Specialist Components Supply Ltd | Wholesale & retail | 2026 |
| Specialist Construction Ltd | Construction | 1999 |
| Specialist Construction Services Limited | Construction | 1989 |
| Specialist Marketing Limited | Wholesale & retail | 2000 |
| Spectra Software Solutions Limited | Information & communication | 2024 |
| Spectrum Alloys Limited | Manufacturing | 1990 |
| Spectrum Inks Limited | Wholesale & retail | 2020 |
| Speedex International Limited | Administrative & support | 2017 |
| Speedy Loic Limited | Wholesale & retail | 2022 |
| Speedy Property Lettings Limited | Real estate | 2023 |
| Speedy Signs Ltd. | Other services | 2001 |
| Speedy's Cars Ltd | Wholesale & retail | 2024 |
| Speedytradinguk Ltd | Wholesale & retail | 2020 |
| SPH Jointing Services Limited | Construction | 2019 |
| SPH Travel Ltd | Transport & logistics | 2023 |
| Sphere Protection Services Ltd | Administrative & support | 2010 |
| SPI Properties Ltd | Real estate | 2019 |
| SPI Surveyors Ltd | Professional & scientific | 2023 |
| Spice Fusion Burslem Limited | Hospitality | 2023 |
| Spice Kickz Ltd | Hospitality | 2024 |
| Spice Larder Limited | Wholesale & retail | 2020 |
| Spice Merchant Express Ltd | Hospitality | 2023 |
| Spice Merchant ST7 Ltd | Hospitality | 2025 |
| Spice N Dosai Limited | Hospitality | 2013 |
| Spice Palace Stoke Ltd | Hospitality | 2026 |
| Spicemill Fastfood Limited | Hospitality | 2025 |
| Spicy HUT Stoke Ltd | Hospitality | 2020 |
| Spicy World Ltd | Hospitality | 2024 |
| Spill Containment UK Ltd | Wholesale & retail | 2021 |
| Spindle Properties Ltd | Real estate | 2024 |
| Spires SA Management Limited | Real estate | 2023 |
| Spirit of Freedom Ltd | Administrative & support | 2022 |
| Splash Design Studio Ltd | Professional & scientific | 2024 |
| Spode Works Regeneration Limited | Real estate | 2024 |
| Spooners Pipe Services Ltd | Construction | 2008 |
| Sporting Club Kaizen Limited | Arts & recreation | 2025 |
| Sporting Pathways Consultancy Limited | Professional & scientific | 2020 |
| Sporting Stars Community Interest Company | Education | 2009 |
| Sportmotive Limited | Wholesale & retail | 2023 |
| Sportsland Limited | Wholesale & retail | 2001 |
| Sportsmatch Limited | Arts & recreation | 2024 |
| Sportykits Sportswear Ltd | Wholesale & retail | 2025 |
| Spot Diagnostics Ltd | Health & social care | 2007 |
| Spot Group Limited | Administrative & support | 2003 |
| Spot Import Export Limited | Wholesale & retail | 2021 |
| Spot Motors Limited | Wholesale & retail | 2018 |
| Spot on Bars Limited | Wholesale & retail | 2017 |
| Spot on Build and Construct Ltd | Construction | 2025 |
| Spot on Roofing Limited | Construction | 2016 |
| Spot Properties Limited | Wholesale & retail | 2015 |
| Spot Service Stations Limited | Wholesale & retail | 2013 |
| Spot Shop Limited | Wholesale & retail | 2017 |
| Spot to LET Limited | Real estate | 2021 |
| Spot Travel and Cargo Limited | Transport & logistics | 2021 |
| Spotless Edge Cleaning Ltd | Administrative & support | 2025 |
| Spray-Synergy Ltd | Other services | 2022 |
| Sprayed Concrete Services Limited | Construction | 2002 |
| Spriggs Holdings Ltd | Professional & scientific | 2023 |
| Spring Property Ltd | Professional & scientific | 2019 |
| Springfield Farm Day Nursery Ltd | Health & social care | 2011 |
| Springfield Foodcourt Limited | Hospitality | 2016 |
| Springfield Tyres Ltd | Wholesale & retail | 2023 |
| Springfields Countryside Caravan and Camping Limited | Hospitality | 2022 |
| Springfields Garage and Vehicle Repairs Limited | Manufacturing | 2012 |
| Springray Limited | Wholesale & retail | 2025 |
| Sprink Holdings Limited | Financial services | 2016 |
| Sprinkled With Magic Limited | Wholesale & retail | 2023 |
| Sprinkles Stoke Limited | Hospitality | 2022 |
| Sprint Motors Ltd | Wholesale & retail | 2020 |
| Sprotech Consulting Limited | Professional & scientific | 2013 |
| Sprout Commodities Trading UK Limited | Wholesale & retail | 2025 |