| Energy Trading Consultancy Limited | Professional & scientific | 2016 |
| Energyseal Doors Ltd | Construction | 2023 |
| Enfr Limited | Information & communication | 2025 |
| Engineering Power Solutions Ltd | Professional & scientific | 2012 |
| Engineering Services North East Limited | Construction | 2017 |
| Engraving Studios Ltd | Manufacturing | 2015 |
| Enhance North East Ltd | Other services | 2025 |
| Enlighten Financial Services Limited | Financial services | 2021 |
| Enpro UK Ltd | Professional & scientific | 2017 |
| Enterprise West Limited | Agriculture & fishing | 1967 |
| Enviro -Tech Maintenance Services Ltd | Construction | 2015 |
| Enviro Gurus Limited | Professional & scientific | 2025 |
| Envizage Referral Marketing Ltd | Professional & scientific | 2014 |
| EPC Engineering Services Ltd | Professional & scientific | 2012 |
| Epcowise Limited | Professional & scientific | 1985 |
| Epiphany Ideas Limited | Other services | 2017 |
| EPS Capital Ltd | Financial services | 2025 |
| Equenimity Limited | Professional & scientific | 2026 |
| Equipt Limited | Professional & scientific | 1999 |
| Equisentials Limited | Wholesale & retail | 2004 |
| Equus Livery Limited | Extraterritorial | 2014 |
| Equus Vehicles Limited | Wholesale & retail | 2009 |
| ER Home Group Ltd | Real estate | 2023 |
| Erin Mortgage and Protection Limited | Financial services | 2023 |
| ERM Office Administration Limited | Professional & scientific | 2014 |
| Erohealth.International Limited | Wholesale & retail | 2026 |
| Esbarex Limited | Other services | 2019 |
| Esne Holdings Limited | Financial services | 2020 |
| Esne Properties Limited | Real estate | 2020 |
| ESP Lubricant Consultants Ltd | Professional & scientific | 2016 |
| Essentia Global Trading Ltd | Wholesale & retail | 2025 |
| Esteem Homecare Services C.I.C. | Administrative & support | 2011 |
| Estoria Group Ltd | Construction | 2025 |
| ET (NE) Holdings Limited | Financial services | 2024 |
| Etail Ventures Group Limited | Wholesale & retail | 2017 |
| Etcetera Lifestyle Magazine Limited | Information & communication | 2017 |
| Ethel’S Edits Ltd | Information & communication | 2020 |
| Eugenius Musica Ltd | Manufacturing | 2021 |
| Euro Trading (N/E) Limited | Wholesale & retail | 2011 |
| European Inst. for Research Support Ltd | Education | 2018 |
| Eva's Inns Limited | Hospitality | 2018 |
| Evaconnect Ltd | Construction | 2025 |
| Evamec Ltd | Manufacturing | 2026 |
| Evegreen Ltd | Wholesale & retail | 2025 |
| Evelisse Ltd | Manufacturing | 2025 |
| Event International Company Limited | Arts & recreation | 1999 |
| Events at IV19 Ltd | Hospitality | 2021 |
| Everclean Commercial Cleaning (Teesside) Limited | Professional & scientific | 2003 |
| Evergreen Holiday Park Limited | Construction | 2015 |
| Evergreen Medicals Ltd | Health & social care | 2022 |
| Everlink Limited | Information & communication | 2018 |
| Everrise Trading & Construction Ltd | Construction | 2025 |
| Every Roof Solar Ltd | Construction | 2024 |
| Evidence Based Coaching Limited | Health & social care | 2019 |
| Evolcom Holdings Limited | Financial services | 2019 |
| Evolcom Ltd | Information & communication | 2016 |
| Evolcom Properties Limited | Real estate | 2017 |
| Evolution Valves Limited | Manufacturing | 2010 |
| Evolve Development Services Ltd | Construction | 2023 |
| Evoprint and Design Limited | Manufacturing | 2014 |
| Evrc Ltd | Wholesale & retail | 2024 |
| EW39 Ltd | Construction | 2018 |
| EX Global Ltd | Construction | 2015 |
| Exhale Group Ltd | Wholesale & retail | 2022 |
| Exhibition ICI Ltd | Construction | 2020 |
| Eximius Medical Ltd | Administrative & support | 2025 |
| Expert Builders Ltd | Construction | 2024 |
| Expert Energy Systems Limited | Extraterritorial | 2009 |
| Expert GAS Services Limited | Construction | 2005 |
| Expertcare Limited | Health & social care | 2010 |
| Express Car Wash Center Ltd | Administrative & support | 2026 |
| Express Peking Limited | Hospitality | 2024 |
| Exsuron Ltd | Construction | 2026 |
| Externv&A Limited | Construction | 2026 |
| Extruit Limited | Manufacturing | 2025 |
| Eyeconsult Middlesbrough Ltd | Health & social care | 2019 |
| Ezichi Limited | Health & social care | 2026 |
| EZO Music Limited | Information & communication | 2023 |
| Ezra & K Limited | Health & social care | 2015 |
| F300 Limited | Real estate | 2025 |
| FAB Deals UK Ltd | Wholesale & retail | 2019 |
| Face House NE Limited | Other services | 2026 |
| Fada Telecom Ltd | Construction | 2023 |
| Fairfield Accountancy Services Ltd | Professional & scientific | 2025 |
| Fairfield Appliance Testing Limited | Professional & scientific | 2025 |
| Fairfield GAS Limited | Construction | 2022 |
| Fairfield Stockton Garage Ltd | Wholesale & retail | 2015 |
| Fairhurst Consulting Ltd | Administrative & support | 2022 |
| Fairview Property Group Ltd | Construction | 2025 |
| Fairy Care Services Ltd | Health & social care | 2022 |
| Falak's Kitchen North East Ltd | Hospitality | 2025 |
| Falcon Building Maintenance Ltd | Construction | 2022 |
| Falcon Enterprises Logistics Ltd | Transport & logistics | 2024 |
| Falconsone Limited | Water & waste | 2019 |
| Fall Timber Limited | Manufacturing | 2021 |
| Family Care Medical Services Limited | Health & social care | 2022 |
| Family Homes NE Limited | Real estate | 2022 |
| Family Outings Ltd | Administrative & support | 2016 |
| Fancy Pants Limited | Arts & recreation | 2013 |
| Fani Smokes Limited | Wholesale & retail | 2023 |