| Silverberg Trade LP | | 2013 |
| Simplescale Ltd | Information & communication | 2021 |
| Simply Hearing Consultants Ltd | Wholesale & retail | 2023 |
| Simpson + Co (Scotland) Ltd | Other services | 2020 |
| Singhawali Food Ltd | Hospitality | 2018 |
| Sioson Ltd | Hospitality | 2024 |
| Siri Cabs Ltd | Transport & logistics | 2025 |
| Sistema Scotland | Arts & recreation | 2006 |
| Sistema Scotland (Trading) Limited | Arts & recreation | 2011 |
| SJ Stewart Transport Ltd. | Transport & logistics | 2002 |
| SJM Electrical Ltd | Construction | 2017 |
| SK Global Trading Ltd | Wholesale & retail | 2025 |
| Sky Barber Ltd | Other services | 2023 |
| Sky Gmac Technology Ltd | Manufacturing | 2021 |
| Sky IS the Limit Competitions Ltd | Arts & recreation | 2025 |
| Skybridge Aviation Investment Partners LLP | | 2025 |
| Skyeforge Enterprises Ltd | Hospitality | 2025 |
| Skyland (Scotland) Ltd. | Wholesale & retail | 2004 |
| SL012975 LP | | 2013 |
| SL031552 LP | | 2017 |
| SL031553 LP | | 2017 |
| SL031554 LP | | 2017 |
| SL031555 LP | | 2017 |
| SL031556 LP | | 2017 |
| SL031580 LP | | 2017 |
| SL031581 LP | | 2017 |
| SL031583 LP | | 2017 |
| SL031658 LP | | 2017 |
| SL031659 LP | | 2017 |
| SL031660 LP | | 2017 |
| SL031661 LP | | 2017 |
| SL031662 LP | | 2017 |
| SL031663 LP | | 2017 |
| SL031664 LP | | 2017 |
| SL031665 LP | | 2017 |
| SL031666 LP | | 2017 |
| SL031667 LP | | 2017 |
| SL031690 LP | | 2017 |
| SL031691 LP | | 2017 |
| SL031692 LP | | 2017 |
| SL031693 LP | | 2017 |
| SL031694 LP | | 2017 |
| SL031723 LP | | 2017 |
| SL031971 LP | | 2017 |
| SL031998 LP | | 2017 |
| Slamannan Village Pharmacy Limited | Administrative & support | 2006 |
| Slicer Mccluskey Butchers Ltd | Wholesale & retail | 2016 |
| SLM Commercial Kitchen Consultants Ltd | Manufacturing | 2021 |
| Slochan Limited | Professional & scientific | 2025 |
| Sloth Property Ltd | Real estate | 2025 |
| Sltb Consulting Ltd | Financial services | 2018 |
| SM2024 Ltd | Hospitality | 2024 |
| Smart Accountants (Scotland) Ltd | Professional & scientific | 2014 |
| Smart Distillery Solutions Limited | Administrative & support | 2021 |
| Smarty Party Ltd | Administrative & support | 2010 |
| SMF Electrical Services Ltd | Manufacturing | 2018 |
| Smith Landscapes of Stirling Limited | Administrative & support | 2010 |
| Smith of Stirling Property Ltd | Real estate | 2024 |
| Smokeys Limited | Hospitality | 2024 |
| Smssh House Limited | Hospitality | 2019 |
| Sngpl Limited | Wholesale & retail | 2025 |
| Sniper & Co. (Stirling) Ltd. | Real estate | 2000 |
| Snorkel Plus Ltd | Wholesale & retail | 2018 |
| Socialudo Ltd | Professional & scientific | 2023 |
| Sodhoppers Ltd | Arts & recreation | 2022 |
| Solar Central Scotland Ltd | Other services | 2021 |
| Solar Constant Ltd | Construction | 2019 |
| Solar Energy Scotland Ltd | Construction | 2019 |
| Solaris Technics LP | | 2017 |
| Solutions for Hospitality Ltd | Professional & scientific | 2024 |
| Somewhere Special Limited | Hospitality | 2002 |
| Sorana Experts LP | | 2016 |
| Soul of Fire Artists' Charcoal Ltd | Manufacturing | 2023 |
| Soul Room Records Ltd | Information & communication | 2018 |
| Soul Room Studios Ltd | Administrative & support | 2024 |
| Soul Sister Crafts Ltd | Wholesale & retail | 2019 |
| Southcrest Limited | Wholesale & retail | 1998 |
| Southedge Properties LP | | 2016 |
| Sowo Limited | Information & communication | 2026 |
| SP Food Safety Consultancy Ltd | Hospitality | 2024 |
| SP Shop Ltd | Real estate | 2020 |
| Spanner Monkey Services Ltd | Manufacturing | 2025 |
| Sparknado Ltd | Construction | 2025 |
| Spears (Risk) Management Limited | Professional & scientific | 2021 |
| Spears Medical Consulting Limited | Health & social care | 2017 |
| Specialist Training Stirling Ltd | Education | 2024 |
| Spendapenny Limited | Information & communication | 2024 |
| Spice Garden Stirling Ltd | Hospitality | 2016 |
| Spirituous Holdings Ltd | Financial services | 2022 |
| Sponsorstack Ltd | Professional & scientific | 2026 |
| Springkerse Auto Centre Ltd | Wholesale & retail | 2012 |
| Springkerse Wines LLP | | 2011 |
| Sprint Design Limited | Manufacturing | 1997 |
| SPY Retails Ltd | Wholesale & retail | 2025 |
| SRA Private Ltd | Wholesale & retail | 2023 |
| SRL Pro Ltd | Professional & scientific | 2019 |
| Srpdatawise Ltd | Information & communication | 2023 |
| Sruighlea HSE Consultancy Ltd | Health & social care | 2018 |
| SS Landscapes & Civils Ltd | Construction | 2025 |
| SSF Hjaltland UK Limited | Agriculture & fishing | 1995 |