| Scents With Love Stirling Ltd | Manufacturing | 2022 |
| Schmetic Ltd | Wholesale & retail | 2020 |
| SCL (Ecosse) Ltd | Construction | 2024 |
| Scobbie Paton Ltd. | Wholesale & retail | 2009 |
| Scone Catering Limited | Hospitality | 2026 |
| Sconz Imports Limited | Wholesale & retail | 2003 |
| Scot BIO Energy Limited | Construction | 2014 |
| Scot Heating Company Limited | Construction | 2011 |
| Scotam Pension Trustees Limited | Financial services | 2013 |
| Scotblinds Larbert Limited | Wholesale & retail | 2005 |
| Scothall Limited | Construction | 2020 |
| Scotia Drainage and Plumbing Ltd | Water & waste | 2021 |
| Scotia Electronics Limited | Extraterritorial | 1990 |
| Scotia Financial Solutions Limited | Professional & scientific | 2020 |
| Scotia Gardens Limited | Administrative & support | 2003 |
| Scotia Pet Supplies Limited | Wholesale & retail | 1948 |
| Scotia Plastics Ltd | Wholesale & retail | 2010 |
| Scotica Wildlife Solutions Ltd | Administrative & support | 2022 |
| Scotital Food Company Ltd | Hospitality | 2013 |
| Scotland's Towns Limited | Other services | 2012 |
| Scotlend Limited | Information & communication | 2016 |
| Scotmaz Machine Tools Limited | Wholesale & retail | 1983 |
| Scotsurg Ltd | Wholesale & retail | 2026 |
| Scott Electric Limited | Construction | 2022 |
| Scott Media Limited | Manufacturing | 2026 |
| Scott Properties (10) Limited | Real estate | 1994 |
| Scott Properties (5 and 6) Limited | Real estate | 1990 |
| Scott Properties (9) Limited | Real estate | 1994 |
| Scott Properties (AYR) Limited | Administrative & support | 2018 |
| Scott Properties (Llanelli) Limited | Administrative & support | 2020 |
| Scott Properties (Newhouse) Limited | Extraterritorial | 2014 |
| Scott Properties (Ponthir) Limited | Extraterritorial | 2012 |
| Scott Properties (Stirling) Limited | Real estate | 2013 |
| Scott Properties Investments Limited | Real estate | 2015 |
| Scott Properties LLP | | 2007 |
| Scott Recycling Investments Limited | Real estate | 2012 |
| Scott's Hill Properties Ltd | Real estate | 2019 |
| Scottdev Ltd | Construction | 2020 |
| Scottish Amicable Life Assurance Society | Professional & scientific | 1983 |
| Scottish Childminding Association | Other services | 1993 |
| Scottish Clay Target Association Limited | Other services | 2000 |
| Scottish Construction Operatives Registration Executive | Other services | 1995 |
| Scottish Natural Stones Limited | Construction | 2008 |
| Scottish Sea Farms Sales Limited | Agriculture & fishing | 1996 |
| Scottish Tourism Alliance | Other services | 2001 |
| Scottish Tourist Guides Association | Administrative & support | 1996 |
| Scottish Triathlon Association Limited | Arts & recreation | 1999 |
| Scottlottie Consultancy Limited | Professional & scientific | 2025 |
| SCS Travel Limited | Administrative & support | 2005 |
| SCT Civils Ltd | Construction | 2025 |
| Sculpt Stirling Ltd | Other services | 2026 |
| SD Construction Consulting Ltd | Construction | 2023 |
| SD Decorating Services Ltd | Construction | 2020 |
| SD Plumbing,Heating & Renewables Ltd | Construction | 2025 |
| Sdil Limited | Financial services | 2020 |
| SDM Orthopaedics Limited | Health & social care | 2022 |
| Sea River Hill Ltd | Education | 2021 |
| Seagold Investments Limited | Financial services | 2013 |
| Seam Junkies Ltd | Manufacturing | 2021 |
| Seaweed Farming Scotland Limited | Agriculture & fishing | 2019 |
| SEC Sales & Marketing Ltd | Wholesale & retail | 2026 |
| Second Sun Retail Limited | Other services | 2021 |
| Secure Scotland Ltd | Other services | 2023 |
| Security Specialists Ltd | Wholesale & retail | 2023 |
| Seesaw Properties Limited | Real estate | 2019 |
| Self Catering Lets Ltd | Real estate | 2020 |
| Selkies Limited | Professional & scientific | 1997 |
| Senor Scoop Ltd | Extraterritorial | 2015 |
| Sentinel Clerk of Works Limited | Construction | 2004 |
| Sentinelle Impacts LP | | 2016 |
| Serenity Cakes Limited | Manufacturing | 2023 |
| Serenx Consulting Limited | Professional & scientific | 2023 |
| Serprocon Ltd | Information & communication | 2018 |
| Seth Diagnostics Limited | Health & social care | 2025 |
| Settie Farm Limited | Agriculture & fishing | 1968 |
| Sgorran Ltd | Agriculture & fishing | 2025 |
| Shado Limited | Information & communication | 2008 |
| Shahrukh Lodhi Ltd | Wholesale & retail | 2025 |
| Shahzadz Limited | Education | 2021 |
| Shalamar Ltd | Wholesale & retail | 2023 |
| Sharon Pearson Ltd. | Agriculture & fishing | 2016 |
| Shaw of Touch Farm | | 1989 |
| Shebang Trading Ltd | Wholesale & retail | 2013 |
| Shedric Global Services Ltd | Real estate | 2022 |
| Shelterstone Software Limited | Information & communication | 2022 |
| Sheret Ltd | Professional & scientific | 2024 |
| Sherwood Creative Ceramics Ltd | Manufacturing | 2026 |
| Shield Safety Solutions LP | | 2017 |
| Shirtbyhand (UK) Ltd. | Wholesale & retail | 2011 |
| Shiva Exports Ltd | Wholesale & retail | 2025 |
| Shoppingeasy Ltd | Wholesale & retail | 2026 |
| Shoshin Taiko Dojo CIC | Arts & recreation | 2021 |
| SHW Agri Ltd | Agriculture & fishing | 2026 |
| Sigmatek Ventures LP | | 2016 |
| Signature Travels and Tours Ltd. | Professional & scientific | 2021 |
| Signs & Lighting Services Ltd. | Construction | 1997 |
| Sils Management Limited | Real estate | 2004 |
| Silver Coyote Limited | Hospitality | 2021 |
| Silver Heather Limited | Real estate | 2022 |
| Silver Machine Limited | Construction | 2003 |