| Saajshine Limited | Administrative & support | 2025 |
| Sabala Limited | Financial services | 2017 |
| Sabe Properties Ltd | Real estate | 2023 |
| Sabkart Ltd | Wholesale & retail | 2025 |
| Sabre Grappling Ltd | Education | 2023 |
| Sacha&Co London Limited | Arts & recreation | 2020 |
| Sada Trading UK Ltd | Wholesale & retail | 2022 |
| Sadatra Ltd | Health & social care | 2019 |
| Saddleworth Properties Limited | Real estate | 2012 |
| Sadler's Lodge Management Limited | Households | 2017 |
| Saeed’S Properties Ltd | Real estate | 2026 |
| Safe Coat Limited | Administrative & support | 2021 |
| Safe Haven Herts & Beds Ltd. | Health & social care | 2017 |
| Safe Sound Solutions Limited | Professional & scientific | 2005 |
| Safe T NET Security Limited | Administrative & support | 2013 |
| Safe Taxis Limited | Transport & logistics | 2024 |
| Safe Water Homes Limited | Real estate | 2022 |
| Safebox Limited | Transport & logistics | 2003 |
| Safety 360UK Limited | Other services | 2012 |
| Saffed Properties Limited | Real estate | 2023 |
| Saffron Garden Design Limited | Other services | 2022 |
| Sage Consulting Herts Limited | Professional & scientific | 2025 |
| Sahota Productions Limited | Information & communication | 2024 |
| Sail Training Centre Ltd | Arts & recreation | 2013 |
| Saint Apollonia Healthcare Limited | Health & social care | 2025 |
| Sakshiyoga Ltd | Other services | 2018 |
| Salamander IT Consulting Limited | Information & communication | 2014 |
| Salient Guitars Limited | Manufacturing | 2022 |
| Salisbury Plaza (NO. 2) Management Company Limited | Households | 1988 |
| Salisbury Plaza (NO. 3) Management Company Limited | Households | 1988 |
| Salix Close (Welwyn) Management Company Limited | Households | 2015 |
| SAM Lewis Band Limited | Arts & recreation | 2018 |
| SAM Lewis Music Limited | Arts & recreation | 2018 |
| Samar Construction Ltd | Construction | 2021 |
| Samarkand Design & Textiles Limited | Wholesale & retail | 2016 |
| Samas Contracts Limited | Other services | 2016 |
| Samgem Associates Limited | Professional & scientific | 2013 |
| Sammyco Limited | Financial services | 2019 |
| Samual's Ltd | Wholesale & retail | 2024 |
| Samuel Beadie (Arlesey) Limited | Construction | 2008 |
| Samuel Beadie (Investments) Limited | Construction | 1996 |
| Samuel Beadie (Residential) Limited | Construction | 2005 |
| Samuels Building Services Limited | Construction | 2020 |
| SAN Carlos on the Green Limited | Hospitality | 2023 |
| Sanderson (Cambridge) Limited | Real estate | 2004 |
| Sandora Group Limited | Other services | 2024 |
| Sandton Healthcare Limited | Health & social care | 2020 |
| Sandy Toes Beach Limited | Professional & scientific | 2025 |
| Sanguine IT Services Limited | Information & communication | 2022 |
| Sanitas Consulting Ltd | Professional & scientific | 2023 |
| Sanming Raymond Tech Ltd | Manufacturing | 2024 |
| Santa Monica Catering Ltd | Hospitality | 2026 |
| Santi Wood Floors and Projects Limited | Construction | 2025 |
| Santosa Property Ltd | Real estate | 2021 |
| SAR Capital Limited | Wholesale & retail | 2022 |
| Saray Catering Ltd | Hospitality | 2024 |
| Sarnies (Beds) Limited | Hospitality | 2012 |
| SAS Fitness Ltd. | Arts & recreation | 2018 |
| Sashara Global Ltd | Transport & logistics | 2023 |
| Sasquared Ventures Limited | Professional & scientific | 2024 |
| Satisfy Recruitment Services Limited | Administrative & support | 2000 |
| Sauce Daddy's Ltd | Manufacturing | 2026 |
| Saulp Transport Ltd | Transport & logistics | 2017 |
| Savemyexams Tutorials Ltd | Financial services | 2020 |
| Savori Ltd | Hospitality | 2025 |
| Savy Nutrition Ltd | Administrative & support | 2025 |
| Saxon Ease Ltd | Construction | 2025 |
| Saxon House RTM Company Limited | Households | 2026 |
| Sayaah Ltd | Wholesale & retail | 2021 |
| SB Home Solutions Limited | Wholesale & retail | 2025 |
| SBA Pubs Ltd | Hospitality | 2023 |
| Sbce Limited | Professional & scientific | 2015 |
| SBG Investments Limited | Arts & recreation | 2017 |
| SBJ Recruitment Services Ltd | Transport & logistics | 2015 |
| SC 360 Services Ltd | Information & communication | 2021 |
| SC Utility Consultants Ltd | Energy | 2023 |
| Scaffleholdings Ltd | Construction | 2018 |
| Scaffolding Frogs Limited | Manufacturing | 2019 |
| Scale Productions Limited | Information & communication | 2016 |
| Scale Trades Online Ltd | Information & communication | 2023 |
| Scarface Promotions and Fitness Limited | Other services | 2021 |
| Scarlet Apartments Ltd | Real estate | 2021 |
| Scarlott Store Ltd | Wholesale & retail | 2021 |
| Schrodinger H.S. Limited | Manufacturing | 2018 |
| Schwetha Limited | Health & social care | 2026 |
| Science Dome Limited | Arts & recreation | 2025 |
| Sciencelogic Limited | Information & communication | 2009 |
| Scilogism Ltd | Professional & scientific | 2015 |
| Scisafe UK Ltd | Other services | 2010 |
| SCM Property Investments Ltd | Real estate | 2026 |
| Scoopy’S Ltd | Administrative & support | 2024 |
| Scoot Studio Limited | Professional & scientific | 2019 |
| Scoptima Limited | Professional & scientific | 2003 |
| Scorer Medical Limited | Health & social care | 2025 |
| Scott Payne Limited | Information & communication | 2016 |
| Scott West Limited | Real estate | 2023 |
| Scotty Hills Coaching Limited | Health & social care | 2023 |
| SCP Healthcare Ltd | Health & social care | 2024 |
| Screen Glue TT Ltd | Information & communication | 2022 |
| SD Commercial Management Limited | Professional & scientific | 2016 |