| Semawi Ltd | Administrative & support | 2024 |
| Semiman Limited | Households | 1990 |
| Sempiterno Ltd | Wholesale & retail | 2017 |
| Senghani Investments Limited | Real estate | 2016 |
| Senishi Limited | Education | 2009 |
| Senrum Ltd | Professional & scientific | 2021 |
| Sentient Films Limited | Information & communication | 2013 |
| Sentnl Ltd | Information & communication | 2020 |
| SEO Design Limited | Information & communication | 2006 |
| Sequence Consultancy Limited | Professional & scientific | 2011 |
| Serendipity Home Care Services Limited | Health & social care | 2022 |
| Serene Consulting NVH Ltd | Professional & scientific | 2018 |
| Serenity Properties Limited | Real estate | 1999 |
| Services for ALL Ltd | Administrative & support | 2017 |
| Services Home Limited | Real estate | 2017 |
| Servmeister Ltd | Professional & scientific | 2021 |
| Setha Sparrow Lane Limited | Construction | 2017 |
| Setpaving Ltd | Construction | 2023 |
| Settlesonic Limited | Financial services | 2020 |
| Seven Colours Cloud Limited | Wholesale & retail | 2019 |
| Seven Global London Limited | Information & communication | 2011 |
| Seven Gordon Avenue (Management Company) Limited | Households | 1980 |
| Seven Gordon Avenue Company Limited | Households | 1984 |
| Seven Holidays Reviews Ltd | Administrative & support | 2016 |
| Seventozero Ltd | Professional & scientific | 2023 |
| Seventy Nine Limited | Administrative & support | 2008 |
| Seylan Limited | Wholesale & retail | 2012 |
| SFI. Constructions Build Ltd | Construction | 2022 |
| SG Trading & Investment Ltd | Professional & scientific | 2023 |
| Sgaami Design and Build Limited | Construction | 2008 |
| SGL Holdings Limited | Wholesale & retail | 2024 |
| SGM Advisors UK Limited | Administrative & support | 2016 |
| SH High London Limited | Education | 2025 |
| Shackadelic Limited | Construction | 2011 |
| Shades of Women C.I.C. | Education | 2024 |
| Shaheda UK Limited | Real estate | 2019 |
| Shahworld Signature Spaces Limited | Real estate | 2025 |
| Shahworld.Co.Uk Limited | Information & communication | 2013 |
| Shak ENG Ltd | Professional & scientific | 2022 |
| Shakil ALI Limited | Hospitality | 2020 |
| Shalini Patel Limited | Health & social care | 2014 |
| Sham IT Ltd | Professional & scientific | 2009 |
| Shanay Care Limited | Professional & scientific | 2018 |
| Shanay Properties Limited | Real estate | 2019 |
| Shannon Carpentry Limited | Manufacturing | 2023 |
| Shantara Limited | Professional & scientific | 2004 |
| Shanti Consulting Services Limited | Information & communication | 2020 |
| Shantiniketan Limited | Real estate | 2009 |
| Sharda Management Limited | Professional & scientific | 2022 |
| Shari Electrical Services Ltd | Construction | 2026 |
| Sharika Consulting Limited | Real estate | 2025 |
| Sharp Equity Limited | Financial services | 2016 |
| Sharp Focus 2021 Limited | Other services | 2021 |
| Sharp Focus Limited | Other services | 2003 |
| Sharpvend Limited | Construction | 1987 |
| Shayriyan Solution Ltd | Information & communication | 2026 |
| SHB Asset Finance Limited | Financial services | 2022 |
| Sheav Chem Limited | Wholesale & retail | 2005 |
| Shebbear College Limited | Education | 2024 |
| Shechtd Ltd | Wholesale & retail | 2026 |
| Shedshed Limited | Health & social care | 2020 |
| Sheeran Development Limited | Professional & scientific | 2016 |
| Sheknows Private Limited | Wholesale & retail | 2025 |
| Shektek Trading Limited | Financial services | 2020 |
| Shelsea Limited | Real estate | 2017 |
| Sherbert Lemons Store Ltd | Wholesale & retail | 2021 |
| Sherif Group Ltd | Wholesale & retail | 2025 |
| Sherim Limited | Professional & scientific | 2026 |
| Shetal Properties Limited | Real estate | 2017 |
| Shico Limited | Construction | 2018 |
| Shift Autohaus Limited | Wholesale & retail | 2026 |
| Shift Shift Ltd | Transport & logistics | 2025 |
| Shine Ventures Ltd | Financial services | 2026 |
| Shino Fades Limited | Other services | 2023 |
| SHIP2SHIP Ltd | Transport & logistics | 2025 |
| Shiraz Express Limited | Hospitality | 2025 |
| Shiraz Safe Electrical Ltd | Manufacturing | 2024 |
| Shisha Bar & Restaurant Limited | | 2008 |
| SHISHA2GO Limited | Wholesale & retail | 2026 |
| Shishafellas Ltd | Hospitality | 2020 |
| Shishaholics Ltd | Hospitality | 2016 |
| Shiv Haria Holdings Ltd | Professional & scientific | 2020 |
| Shiva Properties Limited | Real estate | 2000 |
| Shivay Logistic Ltd | Transport & logistics | 2025 |
| Shivlana Estates Limited | Real estate | 2021 |
| Shivron Care Home Ltd | Health & social care | 2010 |
| Shivron Properties Ltd | Real estate | 2024 |
| Shivsiya Ltd | Financial services | 2014 |
| Shiyan DRY Cleaners Ltd | Other services | 2020 |
| Shoolin Services Ltd | Information & communication | 2016 |
| Shordigan Developments Limited | Real estate | 2002 |
| Shordigan Holdings Limited | Professional & scientific | 1989 |
| Shoreditch Village Ltd | Construction | 1979 |
| Shoreditch Village Residential Ltd | Construction | 2014 |
| Shorefront Solutions Limited | Professional & scientific | 2013 |
| Shoreham Court Investments Limited | Construction | 1952 |
| Short LET Management Limited | Real estate | 2012 |
| Shree Hari International Private Limited | Transport & logistics | 2025 |
| Shree Harikrushna Export Ltd | Wholesale & retail | 2023 |
| Shree Pharma Limited | Wholesale & retail | 2020 |