| Sheridan Project Management Limited | Construction | 2023 |
| Sherlocks Homes Properties Ltd | Real estate | 2022 |
| Shooting Systems Ltd | Information & communication | 2024 |
| Shopmee Ltd | Wholesale & retail | 2022 |
| Shopshoe Ltd | Wholesale & retail | 2019 |
| Short, Bark N Sides Ltd | Other services | 2023 |
| Shrike Maintenance Limited | Construction | 2020 |
| SHS Partners Surgical Limited | Health & social care | 2016 |
| SHS Pathology Limited | Health & social care | 2018 |
| Sian Lund Accountancy and Business Services Ltd | Professional & scientific | 2024 |
| Signwriting by Higgy Ltd | Professional & scientific | 2023 |
| Sikepsych Ltd | Health & social care | 2016 |
| Simple Lettings NW Ltd | Real estate | 2006 |
| Simply YOU Hair & Beauty Limited | Other services | 2012 |
| Sims Group UK Holdings Limited | Professional & scientific | 1994 |
| Sims Group UK Intermediate Holdings Limited | Professional & scientific | 1995 |
| Sims Group UK Pension Trustees Limited | Administrative & support | 1995 |
| Sims Lifecycle Services Limited | Water & waste | 2021 |
| Sims Metal Limited | Extraterritorial | 2021 |
| Sims Metal Management Finance Limited | Financial services | 2017 |
| Sims Renewable Energy Limited | Energy | 2017 |
| Single Storey Extensions Limited | Construction | 2020 |
| Sivori's Cafe Limited | Hospitality | 2020 |
| SJK Property Developments Ltd | Real estate | 2016 |
| SK15 Bar & Bistro Limited | Hospitality | 2023 |
| SK15 Ltd | Professional & scientific | 2017 |
| Skillsmith LLP | | 2016 |
| Sky Blue Solutions Ltd | Administrative & support | 1998 |
| Skyris Ltd | Information & communication | 2023 |
| Slaters Engineering Ltd | Construction | 2013 |
| SLC Properties NW Ltd | Real estate | 2025 |
| Slimmin' Without Women CIC | Extraterritorial | 2017 |
| SLW Imaging Services Ltd | Health & social care | 2023 |
| SM Human Resources Ltd | Professional & scientific | 2015 |
| Smart Fit Installations Ltd | Construction | 2020 |
| Smartco Construction Ltd | Administrative & support | 2017 |
| Smartspace Lettings Limited | Real estate | 2024 |
| SMH Chemicals Ltd | Manufacturing | 2023 |
| Smiles & Surgicals Ltd | Health & social care | 2022 |
| Smoke Vent Solutions Ltd | Construction | 2019 |
| SMS Flooring Ltd | Construction | 2023 |
| Snowhow Limited | Manufacturing | 2010 |
| Social Media Makes Sense Limited | Professional & scientific | 2016 |
| Soft Touch Bodyworks Ltd | Wholesale & retail | 2023 |
| Sold by KJM Ltd | Financial services | 2025 |
| Soldanida Limited | Real estate | 2025 |
| Solid Roots Investments Limited | Real estate | 2025 |
| Solid Roots Properties Limited | Hospitality | 2025 |
| South Manchester Psychologist Ltd | Professional & scientific | 2022 |
| Space Created Ltd | Professional & scientific | 2025 |
| Speak Living Ltd | Real estate | 2019 |
| Spiby Elise Limited | Arts & recreation | 2017 |
| Splash-Tec Limited | Administrative & support | 2013 |
| Sptecc Limited | Information & communication | 2014 |
| SRM Consulting Ltd | Professional & scientific | 2023 |
| Sssigns Installation Ltd | Construction | 2024 |
| Stag Developments of Derbyshire Limited | Real estate | 2022 |
| Staly Mini Market Ltd | Wholesale & retail | 2021 |
| Staly Shop Limited | Wholesale & retail | 2024 |
| Stalybridge Auto Salvage Limited | Water & waste | 2014 |
| Stalybridge Berkeley Construction N.W. Ltd | Construction | 2008 |
| Stalybridge Electrical Services Ltd | Construction | 2018 |
| Stalybridge Nails KK Ltd | Other services | 2025 |
| Stalybridge Powerlifting Club Limited | Information & communication | 2024 |
| Stalybridge Properties Limited | Households | 2024 |
| Stalybridge Recruitment Services Limited | Professional & scientific | 2009 |
| Stalybridge Storage Ltd | Real estate | 2016 |
| Stalymed Limited | Health & social care | 2014 |
| Stamford Group Limited(The) | Professional & scientific | 1982 |
| Stamford Investments Limited | Professional & scientific | 1986 |
| Stamford Products Limited | Manufacturing | 1982 |
| Stamford Trading Ltd | Wholesale & retail | 2012 |
| Stamp Press Limited | Wholesale & retail | 2016 |
| Stancl Limited | Construction | 1995 |
| Stanley Square Kebab House Limited | Hospitality | 2020 |
| Stanlybridge OFF Licence Limited | Wholesale & retail | 2024 |
| Starmagic Games Tech Ltd | Information & communication | 2025 |
| Stayley Limited | Information & communication | 2011 |
| Staypets Ltd | Agriculture & fishing | 2022 |
| Staystrongcollective Ltd | Education | 2021 |
| Steaky Electrical Services Ltd | Construction | 2017 |
| Steele Fitness Ltd | Arts & recreation | 2025 |
| Stepan UK Limited | Manufacturing | 1996 |
| Stephen Chamberlain T/S Ltd | Professional & scientific | 2018 |
| Sterling Care Manchester Ltd | Health & social care | 2022 |
| STJ Engineering Ltd | Administrative & support | 2025 |
| Stmists Limited | Arts & recreation | 2025 |
| Stonefish Ltd | Information & communication | 2000 |
| Stoneswood Offices Ltd | Real estate | 2025 |
| Stoneswood Precision Components Limited | Professional & scientific | 2007 |
| Stopford Accounting Services Limited | Administrative & support | 2014 |
| Strategic Healthcare Services Limited | Professional & scientific | 2014 |
| Strictly Women Affairs Beauty World Ltd | Other services | 2022 |
| Strive Academy Limited | Education | 2022 |
| STT Media Limited | Information & communication | 2023 |
| Studio KMA Ltd | Professional & scientific | 2011 |
| Subfloor Limited | Construction | 2015 |
| Sugarloaf Design Ltd | Professional & scientific | 2016 |
| Sugarplum Moon Limited | Wholesale & retail | 2019 |
| Suka Boutique Ltd | Wholesale & retail | 2023 |