| Design Construction Management Services Limited | Real estate | 2005 |
| Detas Limited | Professional & scientific | 2003 |
| Developing Property Limited | Construction | 2005 |
| DHM Brewery Services Limited | Manufacturing | 2005 |
| Dial Restaurants Limited | Professional & scientific | 2005 |
| Digital Advantage Consulting Ltd | Information & communication | 2000 |
| Digitalfilm Limited | Information & communication | 1988 |
| Diperk (UK) Ltd. | Administrative & support | 2004 |
| Direct Select Limited | | 1980 |
| Dirt Cheap Limited | Professional & scientific | 2002 |
| Displaytrade Limited | Information & communication | 1987 |
| Distinctive Dentistry Limited | Health & social care | 2007 |
| Dj`S Hairdressing Limited | Other services | 2005 |
| Dollar Industries Limited | Wholesale & retail | 1994 |
| Dominic Ball (Woodwind) Limited | Manufacturing | 2003 |
| Don-Bur Service Limited | Extraterritorial | 1987 |
| Double SIX Gaming Ltd | Administrative & support | 2005 |
| Dove Fuels Limited | Wholesale & retail | 1999 |
| Dragon Inn Buffet Limited | Hospitality | 2007 |
| Drainage Supplies UK Limited | Wholesale & retail | 2004 |
| Driven PR Limited | Professional & scientific | 2022 |
| Driven Talent Limited | Professional & scientific | 2022 |
| Driving Test Success Limited | Wholesale & retail | 2021 |
| DTF Manchester Ltd | Wholesale & retail | 2025 |
| Dunham Guest & Lyons Limited | Real estate | 2003 |
| DWS Design Ltd | Professional & scientific | 2006 |
| E-Science Solutions Limited | Information & communication | 2005 |
| E. Hunt Building and Maintenance Ltd | Construction | 2007 |
| E.C.A. Plumbing and Heating Limited | Construction | 2011 |
| E.I.T. Ltd | Real estate | 1996 |
| E.J.A.Frost Limited | Administrative & support | 1958 |
| Early Years International Solutions Ltd | Education | 2026 |
| Ecirrus Limited | Transport & logistics | 2008 |
| Eczemaland Ltd | Wholesale & retail | 2021 |
| Edward Hanson Holdings Ltd | Real estate | 2026 |
| Edward Wood & Company Limited | Financial services | 1999 |
| Edwards Property Renovation Limited | Construction | 2004 |
| Edwards Roofing Limited | Construction | 2004 |
| EGG Sisters Limited | Wholesale & retail | 2024 |
| EGO Hair (Burton) Limited | Other services | 2004 |
| EJ Musk Process Services (Swadlincote) Ltd | Manufacturing | 1987 |
| EJ Parker Technical Services (Central) Ltd | Construction | 1976 |
| Elcot Ltd | Professional & scientific | 2003 |
| Electrical Mechanical Control Systems Limited | Agriculture & fishing | 2003 |
| Electro Appliances Limited | Wholesale & retail | 2005 |
| Electrotech Staffs Limited | Construction | 2007 |
| Element Hinton Limited | Financial services | 1999 |
| Elenora Street Holdings Limited | Professional & scientific | 1961 |
| Eleutheria + Vision Ltd. | Real estate | 2000 |
| Elipse Holdings Limited | Wholesale & retail | 1990 |
| Elite Garage Doors Limited | Construction | 2004 |
| Elite Land & Property Holding Limited | Real estate | 2025 |
| Elite Roofing Limited | Construction | 2003 |
| Elite Scaffold Access Ltd | Construction | 2004 |
| ELM Designs Ltd | Professional & scientific | 2007 |
| Emmson Supplies Ltd | Wholesale & retail | 2005 |
| Emsway Developments Limited | Construction | 1996 |
| Engasol Limited | Professional & scientific | 2008 |
| Entelrail Ltd | Professional & scientific | 1993 |
| Envirocool Ltd | Construction | 2006 |
| Epic Regeneration Services Limited | Real estate | 2007 |
| EPX Group Limited | Information & communication | 2024 |
| Equalbase Cheadle Community Hub Community Interest Company | Other services | 2014 |
| ESP Electrical Ltd | Energy | 2000 |
| Espira Ltd | Professional & scientific | 1999 |
| European Academy of Scientific Research Ltd | Professional & scientific | 2025 |
| European Softwoods Limited | | 1984 |
| Euroseal Windows Limited | Construction | 2001 |
| Euroseal Windows Premier Care Limited | Financial services | 2003 |
| EVA Victoria Bridal Limited | Wholesale & retail | 2023 |
| EVO Project Management Limited | Professional & scientific | 2023 |
| F.W.B. Products Limited | Wholesale & retail | 1982 |
| Falconer Transport Ltd | Transport & logistics | 2005 |
| Farm Services Agricultural Contractors Limited | Agriculture & fishing | 1997 |
| Farmconnect Limited | Agriculture & fishing | 2003 |
| Fayreborn Estates Limited | Extraterritorial | 1992 |
| Febero Limited | Professional & scientific | 2024 |
| Fegg Hayes Pottery Property Limited | Extraterritorial | 2006 |
| Feng's Limited | Hospitality | 2025 |
| Fillybrook House Limited | Health & social care | 2006 |
| Finance 4 Growth Limited | Financial services | 2005 |
| Finning Services Limited | Professional & scientific | 2022 |
| Finning Trustees Limited | Administrative & support | 1990 |
| Fire Risk Management Services Limited | Professional & scientific | 2006 |
| Fire Safety NET Ltd | Professional & scientific | 2008 |
| First Class Gents Barber Ltd | Other services | 2025 |
| First Class Valeting Ltd | Other services | 2003 |
| Firstpost Homes Limited | Construction | 1988 |
| Five Star Windows Limited | Construction | 2002 |
| Flatta Ltd | Manufacturing | 2025 |
| Fluid Restrictors Limited | Manufacturing | 1983 |
| Follwells Limited | Real estate | 2007 |
| Forbes West Limited | Construction | 2006 |
| Force Racing Cars Limited | Manufacturing | 2006 |
| Foresight Contracting Limited | Construction | 2001 |
| Forsite Design Ltd. | Information & communication | 1999 |
| Foster Line Limited | Construction | 1991 |
| Four Oaks Interiors Limited | Construction | 2007 |
| FW Auto Services Ltd | Wholesale & retail | 2023 |
| G & D Paints Limited | Wholesale & retail | 1954 |