| Central Hydraulics (Stoke) Limited | Manufacturing | 2005 |
| Certainseek Limited | Other services | 1987 |
| Chancery Properties Limited | Real estate | 2005 |
| Chase Garage Doors Limited | Other services | 2003 |
| Chasebuild Limited | Construction | 2002 |
| Chasetown Football Club Limited | Arts & recreation | 1987 |
| Chell Auto Repair Services Limited | Wholesale & retail | 2006 |
| Cheslyn Service Station Limited | Wholesale & retail | 1976 |
| Chesterton Take-Away Limited | Hospitality | 2002 |
| Cheviot Enterprises Limited | Other services | 1998 |
| Chilton International Limited | Manufacturing | 2005 |
| Chinedu Ishe Limited | Wholesale & retail | 2025 |
| Chiromotion Ltd | Health & social care | 2020 |
| Chris Brabbs Consultancy Ltd | Health & social care | 2005 |
| Chris Melloy Piano Services Ltd | Professional & scientific | 2006 |
| City and Rural Logistics Ltd | Households | 2023 |
| City Business Services UK Ltd | Professional & scientific | 1999 |
| City Centre Central Private Hire Limited | Transport & logistics | 2006 |
| City Signs (Midlands) Limited | Manufacturing | 1984 |
| City Signs (Stoke-On-Trent) Ltd. | Manufacturing | 1991 |
| Clarebern Limited | Hospitality | 2006 |
| Clarke Environmental Limited | Arts & recreation | 2003 |
| Classone Workforce Ltd | Administrative & support | 2026 |
| Clean Interiors Limited | Administrative & support | 2026 |
| Clear Inspirations Limited | Information & communication | 2007 |
| CMH Design & Consultancy Services Limited | Professional & scientific | 2005 |
| Coliseum Cards Ltd | Wholesale & retail | 2017 |
| Commercial Health & Safety Limited | Health & social care | 2005 |
| Commercial Vehicle Rental Limited | Administrative & support | 1997 |
| Community PUB Hub Ltd | Information & communication | 2025 |
| Compco Limited | Information & communication | 2004 |
| Conlech Enterprises Limited | Households | 2005 |
| Connect Midlands Limited | Other services | 2007 |
| Consort Property Lettings and Management Limited | Real estate | 2016 |
| Construction Card Manager Ltd | Administrative & support | 2004 |
| Cooperari Limited | Administrative & support | 2005 |
| Cope Communications Limited | Information & communication | 2006 |
| Cornerstone Systems Ltd. | Manufacturing | 1986 |
| Corsair Engineering Limited | Manufacturing | 2003 |
| Costdane Limited | Professional & scientific | 1986 |
| Cotterill Fencing Limited | Administrative & support | 2003 |
| Country Dairy Products Limited | Manufacturing | 1990 |
| Country Kids Day Nursery Ltd | Education | 2016 |
| Countrywide Cruisers (Brewood) Limited | Transport & logistics | 1975 |
| County Whips Limited | Manufacturing | 1972 |
| Courty Podmore Limited | Wholesale & retail | 2026 |
| Coyte Carpets Limited | Wholesale & retail | 1977 |
| CP Aerospace Solutions Limited | Information & communication | 2007 |
| CRA Construction Limited | Construction | 2005 |
| Creative Ceramic Laboratory Limited | Health & social care | 2007 |
| Creative Tableware Limited | Professional & scientific | 1964 |
| Croft Crane Services Limited | Manufacturing | 2005 |
| Croft Landscapes Limited | Other services | 2002 |
| Crown Carpets and Flooring (Leek) Limited | Wholesale & retail | 2004 |
| Crown Garage (Leek) Limited | Wholesale & retail | 2004 |
| Crown Power Systems Limited | Wholesale & retail | 1998 |
| Croxley Morris & Company Limited | Information & communication | 1990 |
| Cruso Auto Repairs & C.A.R. Autogas Limited | Wholesale & retail | 2001 |
| Crystal Colours UK Limited | Other services | 2003 |
| Crystech (UK) Limited | Administrative & support | 1994 |
| Curtain Design (Leek) Ltd | Manufacturing | 2006 |
| Cute Marketplace Limited | Wholesale & retail | 2021 |
| Cybersite 2000 Limited | Arts & recreation | 1999 |
| D & HB Associates Limited | Professional & scientific | 1999 |
| D & J Roberts Limited | Construction | 2006 |
| D & R Properties (UK) Limited | Real estate | 2005 |
| D G B G Limited | Hospitality | 2005 |
| D J a (Leek) Limited | Professional & scientific | 2002 |
| D P G Simpkins Limited | Construction | 2002 |
| D W Brown Ltd | Transport & logistics | 2004 |
| D W Haines & Sons Limited | Construction | 2004 |
| D&A Publications Ltd | Information & communication | 2023 |
| D. & K. Evans Limited | Construction | 1981 |
| D.D Decorating Services Limited | Construction | 2003 |
| D.J.C. (Amusements) Limited | Arts & recreation | 1995 |
| D.R. Classic Motorcycles Ltd | Wholesale & retail | 2002 |
| D.R. Murray Services Limited | Transport & logistics | 2002 |
| DAC Automation Midlands Ltd | Manufacturing | 2008 |
| Dacpras Ltd | Manufacturing | 2025 |
| Daffodil Homes Limited | Extraterritorial | 2004 |
| Dance Electrical Limited | Other services | 2004 |
| Dancing Octopus Limited | Information & communication | 2000 |
| Darley Holdings Limited | Financial services | 2007 |
| Dave DEE the Complete Disco Service Ltd | Arts & recreation | 2005 |
| Dave Orme Limited | Construction | 2002 |
| David Craddock Consultancy Services Limited | Professional & scientific | 2000 |
| David Craddock Limited | Professional & scientific | 2000 |
| Dawgk Limited | Real estate | 2021 |
| Daycare Domiciliary Services Limited | Health & social care | 2002 |
| DB Carpentry Joinery & Interiors Limited | Construction | 1998 |
| DC Electrical and Building Services Limited | Construction | 2007 |
| Dealzuper Ltd | Wholesale & retail | 2023 |
| Decor Floors Limited | Construction | 2006 |
| Decouverte Ltd | Professional & scientific | 2002 |
| Decypher Films | Information & communication | 2005 |
| Deker Trailers Limited | Extraterritorial | 1997 |
| Delkevic Limited | Wholesale & retail | 2007 |
| Dellbrook Court Management Limited | Households | 2007 |
| Denstone College Enterprises Limited | Education | 2004 |
| Denstone College Limited | Education | 2004 |